Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Cristina Cecchi"'
Autor:
Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi, Fabrizio Chiti
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/47ee1919563b4474a43a02c85f006f48
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
Autor:
Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral lesions in the
Externí odkaz:
https://doaj.org/article/e31cb433d4c24d6992d739c228d88a50
Autor:
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
Publikováno v:
Annals of Medicine, Vol 55, Iss 1, Pp 72-88 (2023)
AbstractIntroduction: Several neurodegenerative conditions are associated with a common histopathology within neurons of the central nervous system, consisting of the deposition of cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43). Such i
Externí odkaz:
https://doaj.org/article/7e364bb09819442fa3a62e822f0fa695
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/a29d173407c64277bdf04da5ff49c59c
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 11, Pp 2332-2342 (2023)
The misfolding and aggregation of α-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. In
Externí odkaz:
https://doaj.org/article/f9aec9d61e1f481d9eaab50c51f933cf
Autor:
Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, Martino Calamai
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106611- (2023)
Summary: High cholesterol levels are a risk factor for the development of Alzheimer’s disease. Experiments investigating the influence of cholesterol on the proteolytic processing of the amyloid precursor protein (APP) by the β-secretase Bace1 and
Externí odkaz:
https://doaj.org/article/e5cdfea39b1f486bb26e475a39847fc9
Autor:
Francesco Conti, Martina Banchelli, Valentina Bessi, Cristina Cecchi, Fabrizio Chiti, Sara Colantonio, Cristiano D’Andrea, Marella de Angelis, Davide Moroni, Benedetta Nacmias, Maria Antonietta Pascali, Sandro Sorbi, Paolo Matteini
Publikováno v:
Engineering Proceedings, Vol 51, Iss 1, p 14 (2023)
The cerebrospinal fluid (CSF) of 19 subjects who received a clinical diagnosis of Alzheimer’s disease (AD) as well as of 5 pathological controls was collected and analyzed by Raman spectroscopy (RS). We investigated whether the raw and preprocessed
Externí odkaz:
https://doaj.org/article/4263e8fd8b6541dcaa45d780f846cc16
Autor:
Alessandro Samuelly, Marco Audisio, Cristina Cecchi, Simona Carnio, Maria Vittoria Pacchiana, Consuelo Buttigliero
Publikováno v:
Journal of Cancer Rehabilitation, Vol 4, Iss 1, Pp 233-241 (2021)
Cancer’s impact on sexuality has been well documented across all types of cancers, both in patients with active cancers and long-term survivors. As we make progresses in extending survival for cancer patients, we must face the challenge of providin
Externí odkaz:
https://doaj.org/article/10ad2a3c367540028372d6aeb4865bf2
Autor:
Roberta Cascella, Serene W. Chen, Alessandra Bigi, José D. Camino, Catherine K. Xu, Christopher M. Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The self-assembly of α-synuclein (αS) is a pathological feature of Parkinson’s disease. The αS species responsible for neuronal damage are not well characterized. Here, the authors show that αS fibrils release soluble prefibrillar oligomeric sp
Externí odkaz:
https://doaj.org/article/c2f2c92ceab748c787667121d9608d0b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7974 (2023)
The aberrant aggregation of specific peptides and proteins is the common feature of a range of more than 50 human pathologies, collectively referred to as protein misfolding diseases [...]
Externí odkaz:
https://doaj.org/article/da726f11b51c41229c96aac97accb1fe