Novel Polyethers from Screening Actinoallomurus spp.

Autor: Marianna Iorio, Arianna Tocchetti, Joao Carlos Santos Cruz, Giancarlo Del Gatto, Cristina Brunati, Sonia Ilaria Maffioli, Margherita Sosio, Stefano Donadio

Publikováno v: Antibiotics, Vol 7, Iss 2, p 47 (2018)

In screening for novel antibiotics, an attractive element of novelty can be represented by screening previously underexplored groups of microorganisms. We report the results of screening 200 strains belonging to the actinobacterial genus Actinoallomu

Externí odkaz: https://doaj.org/article/85195c37ead6440699c5ff9bca65052e

Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus

Autor: Marianna Iorio, Andrea Gentile, Cristina Brunati, Arianna Tocchetti, Paolo Landini, Sonia Ilaria Maffioli, Stefano Donadio, Margherita Sosio

Publikováno v: RSC Advances. 12:16640-16655

In the search for structurally novel metabolites with antibacterial activity, innovative approaches must be implemented to increase the probability of discovering novel chemistry from microbial sources. Here we report on the application of metabolomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7df553c10f1e1d7bd3e7d51d80b79a
https://doi.org/10.1039/d2ra02094g

Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry

Autor: Sonia I. Maffioli, Stefano Donadio, Cristina Brunati, Silke Alt, Alice Bernasconi, Margherita Sosio

Publikováno v: ACS Chemical Biology. 14:356-360

Glycopeptide antibiotics are used to treat severe multidrug resistant infections caused by Gram-positive bacteria. Dalbavancin is a second generation glycopeptide approved for human use, which is obtained from A40926, a lipoglycopeptide produced by N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9345f605d188331f8a680bb88a5df5
https://doi.org/10.1021/acschembio.9b00050

Effective approaches to discover new microbial metabolites in a large strain library

Autor: Guadalupe S. Zarazúa, Marianna Iorio, Arianna Tocchetti, Mitja M Zdouc, Margherita Sosio, Cristina Brunati, Matteo Simone, Stefania Serina, Kristiina Vind, Max Crüsemann, Paolo Monciardini, Stefano Donadio, Sonia I. Maffioli

Publikováno v: Journal of Industrial Microbiology and Biotechnology
Journal of Industrial Microbiology and Biotechnology, 48(3-4)
Journal of Industrial Microbiology and Biotechnology 48 (2021) 3-4

Natural products have provided many molecules to treat and prevent illnesses in humans, animals and plants. While only a small fraction of the existing microbial diversity has been explored for bioactive metabolites, tens of thousands of molecules ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41e7f3c4b8d748c36a078b7fa82197
https://doi.org/10.1093/jimb/kuab017

Expanding the potential of NAI-107 for treating serious ESKAPE pathogens:synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells

Autor: Anders Løbner-Olesen, Daniela Jabes, Margherita Sosio, Sonia I. Maffioli, Thomas T. Thomsen, Cristina Brunati, Eleonora Gaspari, Stefano Donadio

Publikováno v: Brunati, C, Thomsen, T T, Gaspari, E, Maffioli, S, Sosio, M, Jabes, D, Løbner-Olesen, A & Donadio, S 2018, ' Expanding the potential of NAI-107 for treating serious ESKAPE pathogens : synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells ', The Journal of antimicrobial chemotherapy, vol. 73, no. 2, pp. 414-424 . https://doi.org/10.1093/jac/dkx395
Journal of Antimicrobial Chemotherapy

Objectives: To characterize NAI-107 and related lantibiotics for their in vitro activity against Gram-negative pathogens, alone or in combination with polymyxin, and against non-dividing cells or biofilms of Staphylococcus aureus. NAI-107 was also ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381d47312df9beda1a10259773ddfaaa
https://curis.ku.dk/portal/da/publications/expanding-the-potential-of-nai107-for-treating-serious-eskape-pathogens(724509c8-87da-4032-808f-1667c1560b2b).html