Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Cristina Bertinetti"'
Autor:
Carlos Marugán, Natalia Sanz‐Gómez, Beatriz Ortigosa, Ana Monfort‐Vengut, Cristina Bertinetti, Ana Teijo, Marta González, Alicia Alonso de la Vega, María José Lallena, Gema Moreno‐Bueno, Guillermo deCárcer
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1531-1551 (2024)
Chromosomal instability (CIN) is a hallmark of cancer aggressiveness, providing genetic plasticity and tumor heterogeneity that allows the tumor to evolve and adapt to stress conditions. CIN is considered a cancer therapeutic biomarker because health
Externí odkaz:
https://doaj.org/article/3ef5cfa6ef0a445999dcca9dcaa443a0
Autor:
Michel Siegel, Aman Padamsey, Anna-Lena Bolender, Patrick Hargreaves, Johannes Fraidling, Axel Ducret, Katharina Hartman, Cary M. Looney, Cristina Bertinetti-Lapatki, Olivier Rohr, Timothy P. Hickling, Thomas E. Kraft, Céline Marban-Doran
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmunogenicity refers to the ability of a substance, such as a therapeutic drug, to elicit an immune response. While beneficial in vaccine development, undesirable immunogenicity can compromise the safety and efficacy of therapeutic prote
Externí odkaz:
https://doaj.org/article/7d40f92e19414c188759d42872e0dd4b
Autor:
S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Johannes Sam, Tina Weinzierl, Tanja Fauti, Anne Freimoser-Grundschober, Jan Eckmann, Carina Hage, Martina Geiger, Patrick Ray Ng, William Tien-Street, Dimitris V Manatakis, Virginie Micallef, Regine Gerard, Michael Bscheider, Ekaterina Breous-Nystrom, Anneliese Schneider, Anna Maria Giusti, Cristina Bertinetti-Lapatki, Heather Shannon Grant, Adrian B Roth, Geraldine A Hamilton, Thomas Singer, Katia Karalis, Annie Moisan, Peter Bruenker, Christian Klein, Marina Bacac, Nikolce Gjorevski, Lauriane Cabon
Publikováno v:
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two human Organs-on-Chips to evaluate the safety profile of T-cell bi
Externí odkaz:
https://doaj.org/article/65e3b07242e4472a8bccea9ce9f5ca1b
Autor:
Ramona Nudischer, Kasper Renggli, Andreas Hierlemann, Adrian B Roth, Cristina Bertinetti-Lapatki
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235745 (2020)
Three-dimensional liver in vitro systems have recently attracted a lot of attention in drug development. These systems help to gain unprecedented insights into drug-induced liver injury (DILI), as they more closely reproduce liver biology, and as dru
Externí odkaz:
https://doaj.org/article/e21a5a8ad9c244158b9b849e59109376
Autor:
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Yann Tessier, Claudia McGinnis, Sylwia Huber, Erich Koller, Corinne Ploix, John C Reed, Thomas Singer, Andreas Rothfuss
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187574 (2017)
Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The development of novel ON drug candidates has demonstrated excellent efficacy, but in certain cases
Externí odkaz:
https://doaj.org/article/50e4d29434af416b9fb4beb0c1a70d7a
Autor:
Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz, Maj Hedtjaern, Yann Tessier, Franz Schuler, Thomas Singer, Adrian B Roth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159431 (2016)
Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their proven efficacy, the development of promising SSO drug candidates has been limited by repo
Externí odkaz:
https://doaj.org/article/cc5d924443744c99be2c142b2f6b51f5
Autor:
Ramona Nudischer, Sabine Sewing, Adrian Roth, Barbara M. Elcombe, Andreas Hierlemann, Nicholas Flint, Jean-Christophe Hoflack, Kasper Renggli, Lykke Pedersen, Franziska Boess, Barbara Lenz, Simone Schadt, Cristina Bertinetti-Lapatki, Larry G. Higgins, Audrey Vardy, Laurent Gand
Publikováno v:
Toxicological Sciences. 176:329-342
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of the constitutive andro
Autor:
Serene M. L. Lee, Wolfgang E. Thasler, Tobias S. Schiergens, Karl-Walter Jauch, Cristina Bertinetti-Lapatki, Adrian Roth
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal
Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no
Autor:
Anne Freimoser-Grundschober, Ekaterina Breous-Nystrom, Heather Shannon Grant, Chaitra Belgur, Carina Hage, Anna Maria Giusti, Régine Gérard, Patrick Ray Ng, Martina Geiger, Lauriane Cabon, Adrian Roth, Katia Karalis, Nikolce Gjorevski, Tanja Fauti, Dimitris V. Manatakis, Johannes Sam, Christian Klein, William Tien-Street, Tina Weinzierl, Virginie Micallef, Thomas Singer, Anneliese Schneider, Debora B. Petropolis, Annie Moisan, Peter Bruenker, Jan Eckmann, Geraldine A. Hamilton, S. Jordan Kerns, Cristina Bertinetti-Lapatki, Riccardo Barrile, Michael Bscheider, Marina Bacac, Marianne Kanellias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3636b0fb4a5bf02fa3e3ab9b2eb29a8
https://doi.org/10.7554/elife.67106.sa2
https://doi.org/10.7554/elife.67106.sa2
Autor:
Katia Karalis, Anneliese Schneider, Riccardo Barrile, Annie Moisan, Peter Bruenker, William Tien-Street, Michael Bscheider, Patrick Ray Ng, Régine Gérard, Tanja Fauti, Anna Maria Giusti, Debora B. Petropolis, Ekaterina Breous-Nystrom, Marina Bacac, Johannes Sam, Thomas Singer, Adrian Roth, Nikolce Gjorevski, Tina Weinzierl, Virginie Micallef, Lauriane Cabon, Dimitris V. Manatakis, Carina Hage, Cristina Bertinetti-Lapatki, Jan Eckmann, Geraldine A. Hamilton, Christian Klein, S. Jordan Kerns, Chaitra Belgur, Marianne Kanellias, Anne Freimoser-Grundschober, Heather Shannon Grant, Martina Geiger
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two Organs-on-Chips to evaluate the safety profile of T-cell bispecif