Identification of Potential Skin Sensitizers in Myrrh

Autor: Qi Zhou, Yongbei Liu, Yanran Tang, Yalda Shokoohinia, Amar G. Chittiboyina, Mei Wang, Cristina Avonto

Publikováno v: Cosmetics, Vol 6, Iss 3, p 47 (2019)

The exudate of Commiphora myrrha (myrrh) has been known for centuries as one of the most popular natural skin remedies. The characterization and safety assessment of myrrh ingredients are challenging due to the chemical variability of commercially av

Externí odkaz: https://doaj.org/article/3a3a291c7eb54479ad3bf203c46cd915

Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species

Autor: Manal Alhusban, Pankaj Pandey, Jongmin Ahn, Bharathi Avula, Saqlain Haider, Cristina Avonto, Zulfiqar Ali, Shabana I. Khan, Daneel Ferreira, Ikhlas A. Khan, Amar G. Chittiboyina

Publikováno v: ACS omega. 7(30)

The genus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcea993c0c9a7a9177ce864f7ea9f56
https://pubmed.ncbi.nlm.nih.gov/35936409

Is Isoeugenol a Prehapten? Characterization of a Thiol-Reactive Oxidative Byproduct of Isoeugenol and Potential Implications for Skin Sensitization

Autor: Amar G. Chittiboyina, Jongmin Ahn, Cristina Avonto, Ikhlas A. Khan

Publikováno v: Chemical Research in Toxicology. 33:948-954

Isoeugenol is widely used by the cosmetic and fragrance industries, but it also represents a known cause of skin sensitization adverse effects. Although devoid of a structural alert, isoeugenol has been classified as prehapten in virtue of the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96aef4e5f3d40d1268ba76c824f7381
https://doi.org/10.1021/acs.chemrestox.9b00501

Are atranols the only skin sensitizers in oakmoss? A systematic investigation using non-animal methods

Autor: Mei Wang, Ikhlas A. Khan, Amar G. Chittiboyina, Olivia R. Dale, Shabana I. Khan, Jon F. Parcher, Cristina Avonto

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 70

Oakmoss and treemoss absolutes are the major natural extracts of concern as potential sources of skin sensitizers in cosmetics and personal care products (PCP). Two single constituents, atranol and chloroatranol, have been identified as primary culpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfec34a42ddb976834a0c4ef8fe177a1
https://pubmed.ncbi.nlm.nih.gov/33212168

Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

Autor: Giovanni Appendino, Aniello Schiano Moriello, Pietro Amodeo, Luciano De Petrocellis, Rosa Maria Vitale, Danilo Del Prete, Cristina Avonto

Publikováno v: Journal of natural products
(2020). doi:10.1021/acs.jnatprod.0c00639
info:cnr-pdr/source/autori:Vitale R.M.; Avonto C.; Del Prete D.; Moriello A.S.; Amodeo P.; Appendino G.; De Petrocellis L./titolo:Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides/doi:10.1021%2Facs.jnatprod.0c00639/rivista:Journal of natural products (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Journal of Natural Products

As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (2a) and ursolic acids (3a) were coupled with vanillamine, and the resulting amides (2b and 3b, respectively) were assayed for activity on the vanilloid re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcee1cf07aa7015648503d8935d4d27
http://www.cnr.it/prodotto/i/438893