Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cristina Alonso-Alija"'
Autor:
Johannes-Peter Stasch, Andreas Knorr, Claudia Hirth-Dietrich, Michael Hahn, Michael Härter, Yvonne Keim, Cristina Alonso-Alija, Frank Wunder
Publikováno v:
Arzneimittelforschung. 58:71-80
Liver cirrhosis is a chronic disease with high mortality rate and need for effective pharmacological intervention. The fibrotic remodelling of liver tissue is crucially dependent on hepatic stellate cell activation. Activation of hepatic stellate cel
Autor:
Martin Michels, Holger Paulsen, Cristina Alonso-Alija, Andreas H. Goeller, Hartmut Schirok, Rolf Grosser, Jordi Benet-Buchholz
Publikováno v:
The Journal of Organic Chemistry. 70:9463-9469
[Reaction: see text]. A regioselective and efficient approach toward 6-amino-5-benzoyl-1-substituted 2(1H)-pyridinones by reaction of acyclic ketene aminals with propiolic acid ester was developed. The effect of the solvent and temperature on the reg
Autor:
Emanuel Lohrmann, Cristina Alonso-Alija, Frank Wunder, Johannes-Peter Stasch, Joachim Dr. Hütter, Jörg Hüser
Publikováno v:
Analytical Biochemistry. 339:104-112
We have established a rapid, homogeneous, cell-based, and highly sensitive assay for guanosine 3'-5'-cyclic monophosphate (cGMP) that is suitable for fully automated ultra-high-throughput screening. In this assay system, cGMP production is monitored
Autor:
Torsten Minuth, Heiner Apeler, Matthias Schramm, Klaus Dembowsky, Elke Stahl, Johannes-Peter Stasch, Henning Schröder, Wolfram Steinke, Frank Wunder, Peter Schmidt, Elisabeth Perzborn, Werner Schroeder, Cristina Alonso-Alija, Michael Haerter, Markus Heil, Ulrich Pleiss
Publikováno v:
British Journal of Pharmacology. 136:773-783
1. Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notably in regulating vascular tone and platelet function. s
Autor:
Matthias Schramm, Johannes-Peter Stasch, Cristina Alonso-Alija, Elisabeth Perzborn, Achim Feurer, Klaus Dembowsky, Heiner Apeler, Torsten Minuth, Alexander Straub
Publikováno v:
British Journal of Pharmacology. 135:333-343
BAY 41-8543 is a novel, highly specific and so far the most potent NO-independent stimulator of sGC. Here we report the effects of BAY 41-8543 on the isolated enzyme, endothelial cells, platelets, isolated vessels and Langendorff heart preparation. B
Autor:
Cristina Alonso-Alija, Johannes-Peter Stasch, Bernhard Ducke, Achim Feurer, Jordi Benet-Buchholz, Alexander Straub, Chantal Fürstner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:781-784
SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure loweri
Autor:
Wolfram Steinke, Heiner Apeler, Klaus Dembowsky, Henning Schröder, Matthias Schramm, Eva Maria Becker, Johannes-Peter Stasch, Werner Schroeder, Elisabeth Perzborn, Cristina Alonso-Alija, Achim Feurer, Torsten Minuth, Elke Stahl, Rupert Gerzer, Alexander Straub, Ulrich Pleiß
Publikováno v:
Nature. 410:212-215
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research in the field of NO appears to have followed a straightforward path, and the findings have been progressive: NO and cycli
Publikováno v:
The Journal of Organic Chemistry. 63:4366-4373
Samarium(II) iodide has been employed to promote a tandem intermolecular carbonyl addition/intramolecular nucleophilic acyl substitution sequence, generating seven- through nine-membered monocyclic, bicyclic, and tricyclic ring systems with good yiel
Publikováno v:
Tetrahedron Letters. 43:419-421
A mild and efficient method for the direct conversion of aromatic, benzylic and aliphatic esters to amidines—in the form of their hydrochlorides—has been developed.
Publikováno v:
ChemInform. 28
A method for the opening of cyclopropyl ketones with samarium(II) iodide followed by the intramolecular trapping of an electrophile is described. This process leads to the obtainment of functionalized spirocyclic, bicyclic, and tricyclic ketones in m