GABAA and Glycine Receptor-Mediated Inhibitory Synaptic Transmission onto Adult Rat Lamina IIi PKCγ-Interneurons: Pharmacological but Not Anatomical Specialization

Autor: Corinne El Khoueiry, Cristina Alba-Delgado, Myriam Antri, Maria Gutierrez-Mecinas, Andrew J. Todd, Alain Artola, Radhouane Dallel

Publikováno v: Cells, Vol 11, Iss 8, p 1356 (2022)

Mechanical allodynia (pain to normally innocuous tactile stimuli) is a widespread symptom of inflammatory and neuropathic pain. Spinal or medullary dorsal horn (SDH or MDH) circuits mediating tactile sensation and pain need to interact in order to ev

Externí odkaz: https://doaj.org/article/9af9cae2a5634251989ad7de05a50b48

Neuropathic pain increases spontaneous and noxious-evoked activity of locus coeruleus neurons

Autor: Cristina Alba-Delgado, Esther Berrocoso, Juan Antonio Mico

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2021, 105, pp.110121. ⟨10.1016/j.pnpbp.2020.110121⟩

International audience; The noradrenergic locus coeruleus nucleus is an important station in both the ascending and descending pain regulatory pathways. These neurons discharge in tonic and phasic modes in response to sensory stimuli. However, few st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075c9a53b7b32add9b0bb68c57d36210
https://hal.archives-ouvertes.fr/hal-02980283

5-HT2AReceptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat

Autor: Myriam Antri, Alain Artola, Cristina Alba-Delgado, Lénaïc Monconduit, Radhouane Dallel, Sarah Mountadem, Noëmie Mermet-Joret

Publikováno v: The Journal of Neuroscience. 38:10489-10504

Mechanical allodynia, a widespread pain symptom that still lacks effective therapy, is associated with the activation of a dorsally directed polysynaptic circuit within the spinal dorsal horn (SDH) or medullary dorsal horn (MDH), whereby tactile inpu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34b473b7abe916eba8a070a89ef86395
https://doi.org/10.1523/jneurosci.1294-18.2018

The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain

Autor: Esther Berrocoso, Meritxell Llorca-Torralba, Juan Antonio Mico, Cristina Alba-Delgado

Publikováno v: Pain. 159(12)

Neuropathic pain is a chronic condition that is challenging to treat. It often produces considerable physical disability and emotional distress. Patients with neuropathic pain often experience depression and anxiety both of which are known to be temp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a3ca22058d4c151fad3411352c5c3a
https://pubmed.ncbi.nlm.nih.gov/30130302

Stress Increases the Negative Effects of Chronic Pain on Hippocampal Neurogenesis

Autor: Esther Berrocoso, Juan C. Leza, Beatriz G. Pérez-Nievas, José L. M. Madrigal, Juan Antonio Mico, Carmen Romero-Grimaldi, Cristina Alba-Delgado

Publikováno v: Anesthesia & Analgesia. 121:1078-1088

Patients with chronic pain often suffer from affective disorders and cognitive decline, which significantly impairs their quality of life. In addition, many of these patients also experience stress unrelated to their illness, which can aggravate thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af14fcf96a6c0d3cb860ccbdee605e3
https://doi.org/10.1213/ane.0000000000000838