Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Cristina Aguayo"'
Publikováno v:
Diabetes & Metabolism Journal, Vol 47, Iss 4, Pp 441-453 (2023)
Cellular senescence is accelerated by hyperglycemia through multiple pathways. Therefore, senescence is an important cellular mechanism to consider in the pathophysiology of type 2 diabetes mellitus (T2DM) and an additional therapeutic target. The us
Externí odkaz:
https://doaj.org/article/a04ce7fac839487a9b5d898cb8e4250f
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a0fde109c0534ad1a98ce5307ec69c34
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Cellular senescence is a response to a wide variety of stressors, including DNA damage, oncogene activation and physiologic aging, and pathologically accelerated senescence contributes to human disease, including diabetes mellitus. Indeed, recent wor
Externí odkaz:
https://doaj.org/article/58636ab6223348a39ce96d539f53c1a2
Autor:
Kanako Iwasaki, Benjamin Lalani, Jiho Kahng, Priscila Carapeto, Stephanie Sanjines, Francesko Hela, Cristian Abarca, Tadataka Tsuji, Justin Darcy, Andrzej Bartke, Yu-Hua Tseng, Rohit N. Kulkarni, Cristina Aguayo-Mazzucato
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks
Externí odkaz:
https://doaj.org/article/a9c12083d3e244c1aa69f5f508cb46b4
Publikováno v:
Biology, Vol 12, Iss 9, p 1205 (2023)
Aging leads to an increase in cellular stress due to the fragility of the organism and the inability to cope with it. In this setting, there is a higher chance of developing different cardiometabolic diseases like diabetes. Cellular senescence and au
Externí odkaz:
https://doaj.org/article/637d42ddef01433e890b7c271c590ac6
Autor:
Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, Sandip K. Patel, Joanna Bons, Birgit Schilling, Cristina Aguayo-Mazzucato, Christopher D. Wiley
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (S
Externí odkaz:
https://doaj.org/article/003825a129bd4f75b929b9148cea82e1
Autor:
Alessandro Marsili, Cristina Aguayo-Mazzucato, Ting Chen, Aditi Kumar, Mirra Chung, Elaine P Lunsford, John W Harney, Thuy Van-Tran, Elena Gianetti, Waile Ramadan, Cyril Chou, Susan Bonner-Weir, Philip Reed Larsen, Jorge Enrique Silva, Ann Marie Zavacki
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20832 (2011)
The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired resp
Externí odkaz:
https://doaj.org/article/1dcafe8836a342b4998ec3bb4a900dd3
Autor:
Paloma Cejas, Miriam López-Gómez, Cristina Aguayo, Rosario Madero, Javier de Castro Carpeño, Cristóbal Belda-Iniesta, Jorge Barriuso, Víctor Moreno García, Javier Larrauri, Rocío López, Enrique Casado, Manuel Gonzalez-Barón, Jaime Feliu
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8199 (2009)
BACKGROUND:KRAS mutations in colorectal cancer primary tumors predict resistance to anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody therapy in patients with metastatic colorectal cancer, and thus represent a true indicator of EGFR pa
Externí odkaz:
https://doaj.org/article/ddc7c8806ba34652a87d95ec7f395fad
Autor:
Cristina Aguayo-Mazzucato, Carmen Sanchez-Soto, Victoria Godinez-Puig, Gabriel Gutiérrez-Ospina, Marcia Hiriart
Publikováno v:
PLoS ONE, Vol 1, p e35 (2006)
Function and structure of adult pancreatic islets are determined by early postnatal development, which in rats corresponds to the first month of life. We analyzed changes in blood glucose and hormones during this stage and their association with morp
Externí odkaz:
https://doaj.org/article/e71b827e59ab4d5eaa3a657b20585dd5
Autor:
Nadine Bahour, Lucia Bleichmar, Cristian Abarca, Emeline Wilmann, Stephanie Sanjines, Cristina Aguayo-Mazzucato
Publikováno v:
Aging. 15:441-458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b7dc80521d2c09511a1754572a99e64
https://doi.org/10.18632/aging.204483
https://doi.org/10.18632/aging.204483