Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Cristina A. Ghiani"'
Autor:
Emily Chiem, Kevin Zhao, Derek Dell’Angelica, Cristina A. Ghiani, Ketema N. Paul, Christopher S. Colwell
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Sleep disturbances are common features of neurodegenerative disorders including Huntington’s disease (HD). Sleep and circadian disruptions are recapitulated in animal models, providing the opportunity to evaluate the effectiveness of circadian inte
Externí odkaz:
https://doaj.org/article/1b0b6d5f0345425da4c48248c20330a2
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1777 (2024)
Huntington’s Disease (HD) is a neurodegenerative disorder caused by an autosomal-dominant mutation in the huntingtin gene, which manifests with a triad of motor, cognitive and psychiatric declines. Individuals with HD often present with disturbed s
Externí odkaz:
https://doaj.org/article/e6aa1014d5804d979ee5ebaf21f78b75
Autor:
Huei-Bin Wang, David Zhou, Shu Hon Christopher Luk, Hye In Cha, Amanda Mac, Rim Chae, Anna Matynia, Ben Harrison, Sina Afshari, Gene D. Block, Cristina A. Ghiani, Christopher S. Colwell
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105944- (2023)
Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycles, and they may be particularly vulnerable to the impact of circadian disruptors. We have previously shown that a 2-weeks exposure to dim light at night (DL
Externí odkaz:
https://doaj.org/article/ed54fde324d04658bb9ca4008f10a276
Autor:
Daniel S. Whittaker, T. Katherine Tamai, Raj S. Bains, Sophia Anne Marie Villanueva, Shu Hon Christopher Luk, Derek Dell’Angelica, Gene D. Block, Cristina A. Ghiani, Christopher S. Colwell
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Disturbances in sleep/wake cycles are common among patients with neurodegenerative diseases including Huntington’s disease (HD) and represent an appealing target for chrono-nutrition-based interventions. In the present work, we sought to determine
Externí odkaz:
https://doaj.org/article/ae7f3030be4548399a07fc4fb7689600
Autor:
Saemi Park, Shu Hon Christopher Luk, Raj S. Bains, Daniel S. Whittaker, Emily Chiem, Maria C. Jordan, Kenneth P. Roos, Cristina A. Ghiani, Christopher S. Colwell
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Individuals affected by Huntington's disease (HD) present with progressive degeneration that results in a wide range of symptoms, including cardiovascular (CV) dysfunction. The huntingtin gene (HTT) and its product are ubiquitously expressed, hence,
Externí odkaz:
https://doaj.org/article/106367ac61e34a388ac27c30daadd49b
Autor:
Huei Bin Wang, Yu Tahara, Shu Hon Christopher Luk, Yoon-Sik Kim, Olivia N. Hitchcock, Zoe A. MacDowell Kaswan, Yang In Kim, Gene D. Block, Cristina A. Ghiani, Dawn H. Loh, Christopher S. Colwell
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105064- (2020)
Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, and may be particularly vulnerable to the impact of circadian disruptors. In t
Externí odkaz:
https://doaj.org/article/8bb8305e55d547b38034b7b58f38d13a
Autor:
Huei-Bin Wang, Daniel S. Whittaker, Danny Truong, Aly K. Mulji, Cristina A. Ghiani, Dawn H. Loh, Christopher S. Colwell
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 2, Iss , Pp 39-52 (2017)
Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue duri
Externí odkaz:
https://doaj.org/article/370d5ad6b9174ea48098c2cce0bd4700
Autor:
Frank Y. Lee, Huei-Bin Wang, Olivia N. Hitchcock, Dawn Hsiao Loh, Daniel S. Whittaker, Yoon-Sik Kim, Achilles Aiken, Collette Kokikian, Esteban C. Dell’Angelica, Christopher S. Colwell, Cristina A. Ghiani
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Mice lacking a functional Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1), such as those of the pallid line, display cognitive and behavioural impairments reminiscent of those presented by individuals with intellectual and developmental
Externí odkaz:
https://doaj.org/article/0a85d57e01b44801bb9f8188b63f4332
Autor:
Quan Li, Dawn H. Loh, Takashi Kudo, Danny Truong, Matthew Derakhshesh, Zoë MacDowell Kaswan, Cristina A. Ghiani, Rosemarie Tsoa, Yin Cheng, Yi E. Sun, Christopher S. Colwell
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 155-164 (2015)
Disturbances in the sleep/wake cycle are prevalent in patients with Rett syndrome (RTT). We sought to determine whether the circadian system is disrupted in a RTT model, Mecp2−/y mice. We found that MeCP2 mutants showed decreased strength and preci
Externí odkaz:
https://doaj.org/article/8b0fb039cd8e41b18d0f2bedc9a8ba1e
Autor:
Natalia S. Mattan, Cristina A. Ghiani, Marcia Lloyd, Reuben Matalon, Dean Bok, Patrizia Casaccia, Jean de Vellis
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 2, Pp 432-443 (2010)
Canavan disease (CD) is a neurodegenerative disease, caused by a deficiency in the enzyme aspartoacylase (ASPA). This enzyme has been localized to oligodendrocytes; however, it is still undefined how ASPA deficiency affects oligodendrocyte developmen
Externí odkaz:
https://doaj.org/article/3c27be2726d84e8a9b6729ee9ed721ec