Ca 2+ attenuates nucleation activity of leiomodin

Autor: Garry E. Smith, Dmitri Tolkatchev, Cristina Risi, Madison Little, Carol C. Gregorio, Vitold E. Galkin, Alla S. Kostyukova

Publikováno v: Protein Science. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7774da31a34b6be3108e64af9fe29a83
https://doi.org/10.1002/pro.4358

The structure of the native cardiac thin filament at systolic Ca 2+ levels

Autor: Cristina Risi, Vitold E. Galkin, Kelly A. Dryden, Betty Belknap, Howard D. White, Maicon Landim-Vieira, P. Bryant Chase, Ian Pepper, Jose R. Pinto

Publikováno v: Proc Natl Acad Sci U S A

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments orchestrated by rising and falling Ca(2+) levels. Thin filaments are comprised of two actin strands, each harboring equally separated troponin complexes, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43bd0e9566cfe2700f4c773b3f03d17
https://doi.org/10.1073/pnas.2024288118

Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii

Autor: Andressa Patrícia Alves Pinto, Marcos V.A.S. Navarro, Frederico Moraes Ferreira, Ricardo DeMarco, Cristina Risi, Ana Paula Ulian de Araújo, Heloisa Ciol, Richard Charles Garratt, José Brandão-Neto, Ana Eliza Zeraik, Humberto M. Pereira, Vitold E. Galkin

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Septins are filament-forming GTP-binding proteins involved in many essential cellular events related to cytoskeletal dynamics and maintenance. Septins can self-assemble into heterocomplexes, which polymerize into highly organized, cell membrane-inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ba5229787c33a4b8bc734f0e3ec847
https://doi.org/10.1074/jbc.m116.762229

High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex

Autor: Betty Belknap, Vitold E. Galkin, Gunnar F. Schröder, Howard D. White, Ian Pepper, Cristina Risi, Luisa U. Schäfer

Publikováno v: Structure
Structure 29(1), 50-60.e4 (2021). doi:10.1016/j.str.2020.09.013

Summary Heart contraction depends on a complicated array of interactions between sarcomeric proteins required to convert chemical energy into mechanical force. Cyclic interactions between actin and myosin molecules, controlled by troponin and tropomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32c7f80a7434db99a657de99fd0b2dd
https://doi.org/10.1016/j.str.2020.09.013

Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy

Autor: Betty Belknap, Gunnar F. Schröder, Howard D. White, Jamie Eisner, David H. Heeley, Cristina Risi, Vitold E. Galkin

Muscle contraction relies on the interaction of myosin motors with F-actin, which is regulated through a translocation of tropomyosin by the troponin complex in response to Ca2+. The current model of muscle regulation holds that at relaxing (low-Ca2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61a7cef9103bf9121c09e04e3f8944e
https://europepmc.org/articles/PMC5495243/