Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

Autor: Javier García-Pérez, Alberto M. Borobia, Mayte Pérez-Olmeda, Antonio Portolés, Luis Castaño, Magdalena Campins-Artí, María Jesús Bertrán, Mercedes Bermejo, José Ramón Arribas, Andrea López, Ana Ascaso-del-Rio, Eunate Arana-Arri, Inmaculada Fuentes Camps, Anna Vilella, Almudena Cascajero, María Teresa García-Morales, María Castillo de la Osa, Carla Pérez Ingidua, David Lora, Paloma Jiménez-Santana, Silvia Pino-Rosa, Agustín Gómez de la Cámara, Erick De La Torre-Tarazona, Esther Calonge, Raquel Cruces, Cristóbal Belda-Iniesta, José Alcamí, Jesús Frías, Antonio J. Carcas, Francisco Díez-Fuertes, Lucía Díaz García, Elena Ramírez García, Enrique Seco Meseguer, Stefan Mark Stewart Balbàs, Alicia Marín Candón, Irene García García, Mikel Urroz Elizalde, Paula de la Rosa, Marta Sanz García, Cristina López Crespo, Vega Mauleón Martínez, Raquel de Madariaga Castell, Laura Vitón Vara, Rocío Prieto-Pérez, Emilio Vargas-Castrillón, Leonor Laredo, Ouhao Zhu-Huang, Teresa Iglesias, Natale Imaz-Ayo, Susana Meijide, Aitor García de Vicuña, Ana Santorcuato, Iraide Exposito, Sara de Benito, Alazne Bustinza, Mikel Gallego, Dolores García-Vázquez, Ana Belén de la Hoz, Gustavo Pérez-Nanclares, Josu Aurrekoetxea, Ines Urrutia, Rosa Martínez-Salazar, Janire Orcajo, Begoña Calvo, June Corcuera, Olaia Velasco, Anibal Aguayo, Xavier Martínez-Gómez, Susana Otero-Romero, Lluis Armadans, Blanca Borras-Bermejo, Oleguer Parés, Sonia Uriona, José Ángel Rodrigo Pendás, Cesar Llorente, José Santos, Laia Pinós, Lina Camacho, Judith Riera, Carla Sans, Antonia Agustí, Carmen Altadill, Carla Aguilar Blancafort, Gisela Gili Serrat, Aitana Plaza, Anna Feliu Prius, Maria Margarita Torrens, Esther Palacio, Gloria Torres, Julia Calonge, Elena Ballarin Alins, Eulàlia Pérez-Esquirol, Lourdes Vendrell Bosch, Marta Aldea, Eugènia Mellado, Ma Ángeles Marcos, Marta Tortajada, Lourdes E. Barón-Mira, Laura Granés, Sulayman Lazaar, Sara Herranz, Montserrat Malet, Sebastiana Quesada, Anna Llupià, Victoria Olivé, Antoni Trilla, Begoña Gómez, Elisenda González, Sheila Romero, Francisco Javier Gámez, Cristina Casals, Laura Burunat, Juan José Castelló, Patricia Fernández, Josep Lluís Bedini, Jordi Vila, Juan Carlos Hurtado, Isabel Jado, Giovanni Fedele, Concepción Perea, Mónica González, Isabel Grajera, María Ángeles Murillo, Pilar Balfagón, Irene Díaz-Marín, Gema González-Pardo

Publikováno v: iScience, Vol 27, Iss 9, Pp 110728- (2024)

Summary: CombiVacS study has demonstrated a strong immune response of the heterologous ChAdOx1-S/BNT162b2 vaccine combination. The primary outcomes of the study were to assess the humoral immune response against SARS-CoV-2, 28 days after a third dose

Externí odkaz: https://doaj.org/article/1d8485bc140e4998a160d76238a98bff

Retrospective analysis of epidemiologic features and clinical course of COVID-19 patients and comparison between vaccinated and unvaccinated patients

Autor: Domenica Di Costanzo, Mariano Mazza, Andreina Carbone, Anna Pratillo, Felice Di Perna, Vittoria Graziani, Cristina Casals Marin, Stefania Tartaglione, Antonio Ponticiello

Publikováno v: Monaldi Archives for Chest Disease (2023)

At our Pneumology Department, we dealt with three waves of COVID-19 pandemics. The purpose of this study is to compare patients' epidemiological and clinical characteristics across waves and to assess the effect of vaccination on clinical presentatio

Externí odkaz: https://doaj.org/article/0a5e685ed13947caacb2ba29f9d6e22d

Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction

Autor: Lidia Feo-Lucas, Cristina Godio, María Minguito de la Escalera, Natalia Alvarez-Ladrón, Laura H. Villarrubia, Adrián Vega-Pérez, Leticia González-Cintado, Jorge Domínguez-Andrés, Belén García-Fojeda, Carlos Montero-Fernández, Cristina Casals, Chiara Autilio, Jesús Pérez-Gil, Georgiana Crainiciuc, Andrés Hidalgo, María López-Bravo, Carlos Ardavín

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remain

Externí odkaz: https://doaj.org/article/3f66a8b083034c48bba53e50f4d065f2

Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria

Autor: Juan Manuel Coya, Víctor Fraile-Ágreda, Lidia de Tapia, Belén García-Fojeda, Alejandra Sáenz, José A. Bengoechea, Nina Kronqvist, Jan Johansson, Cristina Casals

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The exploration of therapies combining antimicrobial lung proteins and conventional antibiotics is important due to the growing problem of multidrug-resistant bacteria. The aim of this study was to investigate whether human SP-A and a recombinant tri

Externí odkaz: https://doaj.org/article/7efda82791254f3697a49e40591c3553

Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

Autor: Adrián Montes-de-Oca-García, Juan Corral-Pérez, Daniel Velázquez-Díaz, Alejandro Perez-Bey, María Rebollo-Ramos, Alberto Marín-Galindo, Félix Gómez-Gallego, Maria Calderon-Dominguez, Cristina Casals, Jesús G. Ponce-González

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The

Externí odkaz: https://doaj.org/article/ce891789e9554b7da3bd15c2b12f2b83