Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F1FO-ATPase and Mitochondrial Permeability Transition Pore Formation

Autor: Vincenzo Algieri, Cristina Algieri, Paola Costanzo, Giulia Fiorani, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida, Fabiana Trombetti, Loredana Maiuolo, Antonio De Nino, Salvatore Nesci

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 498 (2023)

An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Ena

Externí odkaz: https://doaj.org/article/7abf87217f564943adb97d40f357b610

Biological characteristics and metabolic profile of canine mesenchymal stem cells isolated from adipose tissue and umbilical cord matrix.

Autor: Romina Marcoccia, Salvatore Nesci, Barbara Merlo, Giulia Ballotta, Cristina Algieri, Alessandra Pagliarani, Eleonora Iacono

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0247567 (2021)

Despite the increasing demand of cellular therapies for dogs, little is known on the differences between adult and fetal adnexa canine mesenchymal stem cells (MSCs), and data on their metabolic features are lacking. The present study aimed at compari

Externí odkaz: https://doaj.org/article/2295165d97504124a68e0ab6e8b9113b

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

Autor: Salvatore Nesci, Fabiana Trombetti, Alessandra Pagliarani, Vittoria Ventrella, Cristina Algieri, Gaia Tioli, Giorgio Lenaz

Publikováno v: Life, Vol 11, Iss 3, p 242 (2021)

Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the energy released by nutrient oxidation into ATP, the currency of living organisms. The whole biochemical machinery is hosted by the inner mitochondrial membrane (m

Externí odkaz: https://doaj.org/article/1313825b099e46a79deabb214be4078f

Effects of cryopreservation on the mitochondrial bioenergetics of bovine sperm

Autor: Cristina Algieri, Olga Blanco‐Prieto, Marc Llavanera, Marc Yeste, Marcella Spinaci, Gaetano Mari, Diego Bucci, Salvatore Nesci

Publikováno v: Reproduction in Domestic Animals, 2022, Online Version of Record before inclusion in an issue
Articles publicats (D-B)
Algieri, Cristina Blanco Prieto, Olga Llavanera, Marc Yeste Oliveras, Marc Spinaci, Marcella Mari, Gaetano Bucci, Diego Nesci, Salvatore 2022 Effects of cryopreservation on the mitochondrial bioenergetics of bovine sperm Reproduction in Domestic Animals
DUGiDocs – Universitat de Girona
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This study evaluated the bioenergetic map of mitochondria metabolism in cryopreserved bovine sperm. The detected oligomycin-sensitive basal respiration supported ATP production; frozen-thawed spermatozoa were found to have a coupling efficiency highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6618663abcff749073342bbf01fbd7c2
https://hdl.handle.net/11585/901794

The inhibition of gadolinium ion (Gd3+) on the mitochondrial F1FO-ATPase is linked to the modulation of the mitochondrial permeability transition pore

Autor: Cristina Algieri, Alessandra Pagliarani, Salvatore Nesci, Fabiana Trombetti, Micaela Fabbri

Publikováno v: International Journal of Biological Macromolecules. 184:250-258

open 5 no The mitochondrial permeability transition pore (PTP), which drives regulated cell death when Ca2+ concentration suddenly increases in mitochondria, was related to changes in the Ca2+-activated F1FO-ATPase. The effects of the gadolinium cati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df369fbf161e42eddaab0581d09b7cc
https://doi.org/10.1016/j.ijbiomac.2021.06.065