Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Cristin Davidson"'
Autor:
Sonali Mishra, Pamela Kell, David Scherrer, Dennis J. Dietzen, Charles H. Vite, Elizabeth Berry-Kravis, Cristin Davidson, Stephanie M. Cologna, Forbes D. Porter, Daniel S. Ory, Xuntian Jiang
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 8, Pp 100600- (2024)
Lysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol. The precise pathogenic mechanism of NPC1 remains i
Externí odkaz:
https://doaj.org/article/69e323f6f49244688375dc2088920f9e
Autor:
Martin Fan, Rohini Sidhu, Hideji Fujiwara, Brett Tortelli, Jessie Zhang, Cristin Davidson, Steven U. Walkley, Jessica H. Bagel, Charles Vite, Nicole M. Yanjanin, Forbes D. Porter, Jean E. Schaffer, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2800-2814 (2013)
Niemann-Pick type C (NPC)1 is a rare neurodegenerative disease for which treatment options are limited. A major barrier to development of effective treatments has been the lack of validated biomarkers to monitor disease progression or serve as outcom
Externí odkaz:
https://doaj.org/article/f9bbecc4235d4c589711bf7c3ede8239
Autor:
Andrew S. Herbert, Cristin Davidson, Ana I. Kuehne, Russell Bakken, Stephen Z. Braigen, Kathryn E. Gunn, Sean P. Whelan, Thijn R. Brummelkamp, Nancy A. Twenhafel, Kartik Chandran, Steven U. Walkley, John M. Dye
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogen
Externí odkaz:
https://doaj.org/article/263ccfc6711f4321bc9f6e259ae2e4fb
Autor:
Nisc Comparative Sequencing Program, Jorge L Rodriguez-Gil, Steven R Carlson, Kerri L. Wallom, William J. Pavan, Dawn E. Watkins-Chow, Forbes D. Porter, Arturo Incao, Laura L. Baxter, Ryan K. Dale, Frances M. Platt, Cristin Davidson, Nicole Y. Farhat, Nicholas L Johnson
Publikováno v:
Hum Mol Genet
The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fd8542d21d8f932f63fe54e571e696
https://doi.org/10.1093/hmg/ddab194
https://doi.org/10.1093/hmg/ddab194
Autor:
Hideji Fujiwara, Viviana Gradinaru, Tansy Gu, Benjamin E. Deverman, Xuntian Jiang, Arturo Incao, Jorge L. Rodriguez-Gil, Laura L. Baxter, Charles P. Venditti, Keith Beadle, Cristin Davidson, Randy J. Chandler, Daniel S. Ory, William J. Pavan, Alana L. Gibson
Publikováno v:
Life Science Alliance
This work highlights the importance of CNS transduction for treatment of neurological diseases, a finding with significant clinical implications considering the long-lasting effects of gene therapy.
Niemann–Pick C1 disease (NPC1) is a rare, fa
Niemann–Pick C1 disease (NPC1) is a rare, fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf252833fb091e6c917134085a2d37c
https://resolver.caltech.edu/CaltechAUTHORS:20210930-210049351
https://resolver.caltech.edu/CaltechAUTHORS:20210930-210049351
Autor:
Giuseppe Scesa, Estefania Zarate, Cristin Davidson, Maria I. Givogri, Stephanie M. Cologna, Melissa R Pergande, Ernesto R. Bongarzone, Carol Haney-Ball
Publikováno v:
Bioanalysis
Aim: Mass spectrometry (MS)-based proteomics, particularly with the development of nano-ESI, have been invaluable to our understanding of altered proteins related to human disease. Niemann–Pick, type C1 (NPC1) disease is a fatal, autosomal recessiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc5f5683cf1179b9f14bc92e118a826
https://doi.org/10.4155/bio-2018-0232
https://doi.org/10.4155/bio-2018-0232
Autor:
Cristin Davidson, Mason Fellmeth, Forbes D. Porter, Tansy Gu, William J. Pavan, Antony Cougnoux, Alana L. Gibson
Publikováno v:
Mol Genet Metab
Niemann-Pick disease, type C1 (NPC1) is a rare neurodegenerative lysosomal storage disease with a wide spectrum of clinical manifestation. Multiple genetic factors influence the NPC1 mouse phenotype, but very little attention has been given to prenat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f33534a7ae69f34fede30e8345f7802
https://pubmed.ncbi.nlm.nih.gov/31668555
https://pubmed.ncbi.nlm.nih.gov/31668555
Autor:
Nina H. Pipalia, Xin Xu, Samantha Moores, Xuntian Jiang, Michael Grigalunas, Olaf Wiest, Hideji Fujiwara, Paul Helquist, Jean E. Schaffer, Sarah E. Gale, Frederick R. Maxfield, Cristin Davidson, Farbod Salahi, Steven U. Walkley, Gang Liu, Bruce J. Melancon, Rohini Sidhu, Jessica Davidson, Kanagaraj Subramanian, Pamela Kell, Dana Cruz, Daniel S. Ory, Jesse Zhang, Edward B. Holson, Elizabeth A. Molitor, Forbes D. Porter
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
Niemann-Pick type C1 (NPC1) disease is a fatal neurovisceral disease for which there are no FDA approved treatments, though cyclodextrin (HPβCD) slows disease progression in preclinical models and in an early phase clinical trial. Our goal was to ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8a6def6a85a87eb028dfe857c0d033
https://europepmc.org/articles/PMC6679735/
https://europepmc.org/articles/PMC6679735/
Autor:
Jakub Sikora, Brett A. Tortelli, Daniel S. Ory, Steven U. Walkley, Jessie Zhang, Zhouji Chen, Hideji Fujiwara, Jean E. Schaffer, Andrew P. Lieberman, Anita Chacko, Chan Chung, Rohini Sidhu, Cristin Davidson, Maria Praggastis, Frederick R. Maxfield, Nina H. Pipalia
Publikováno v:
The Journal of Neuroscience. 35:8091-8106
Niemann-Pick Type C1 (NPC1) disease is a rare neurovisceral, cholesterol–sphingolipid lysosomal storage disorder characterized by ataxia, motor impairment, progressive intellectual decline, and dementia. The most prevalent mutation, NPC1I1061T, enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09537350e7c0d970c3869f99645c9503
https://doi.org/10.1523/jneurosci.4173-14.2015
https://doi.org/10.1523/jneurosci.4173-14.2015
Autor:
Cristin Davidson, Tansy Gu, William J. Pavan, Alana L. Gibson, Benjamin E. Deverman, Viviana Gradinaru, Randy J. Chandler, Charles P. Venditti
Publikováno v:
Molecular Genetics and Metabolism. 123:S36-S37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3d924fe5c5a30918ab8def876d0c7c
https://doi.org/10.1016/j.ymgme.2017.12.075
https://doi.org/10.1016/j.ymgme.2017.12.075