Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Cristiano J. Macuamule"'
Autor:
Kevin J. Saliba, Gordon Wells, Christina Spry, Erick Strauss, Marianne de Villiers, Leanne Barnard, Cristiano J. Macuamule
Publikováno v:
ACS Infectious Diseases. 3:527-541
N-Substituted pantothenamides (PanAms) are pantothenate analogues with up to nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species responsible for malaria). Although these compounds are known to target coenzyme A (CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dbb639a30b792acd588e9adbddff69
https://doi.org/10.1021/acsinfecdis.7b00024
https://doi.org/10.1021/acsinfecdis.7b00024
Autor:
Kevin J. Saliba, Leanne Barnard, Erick Strauss, Marianne de Villiers, Lizbé Koekemoer, Erick T. Tjhin, Cristiano J. Macuamule, Collins E. Jana
Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC 50 ], ∼20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00f1e625265fcc8a4dfc8b2b0c89188
https://europepmc.org/articles/PMC4432145/
https://europepmc.org/articles/PMC4432145/
Autor:
Yoo-Min Hyun, Cristiano J. Macuamule, Kevin J. Saliba, Christina Spry, Erick Strauss, Marianne de Villiers
Publikováno v:
ACS medicinal chemistry letters. 4(8)
Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has demonstrated that pantothenamides inhibit the growth of blood-stage Plasmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b8d3cfc72b609fd0a6ca33889d8d46
https://pubmed.ncbi.nlm.nih.gov/24900746
https://pubmed.ncbi.nlm.nih.gov/24900746
Autor:
Kevin J. Saliba, Kristopher G. Virga, Erick Strauss, Christina Spry, Cristiano J. Macuamule, Richard E. Lee, Zhiyang Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54974 (2013)
PLoS ONE
PLoS ONE
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e174b7766776c339f5ee64eec2934e
http://europepmc.org/articles/PMC3566143?pdf=render
http://europepmc.org/articles/PMC3566143?pdf=render