Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cristiano G Ponte"'
Autor:
André M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimarães, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pâmella Dourila N. Souza, David William Provance, José Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo
Publikováno v:
Molecules, Vol 27, Iss 4, p 1151 (2022)
The Piper species are a recognized botanical source of a broad structural diversity of lignans and its derivatives. For the first time, Piper tectoniifolium Kunth is presented as a promising natural source of the bioactive (−)-grandisin. Phytochemi
Externí odkaz:
https://doaj.org/article/36eb7dd8e14c43a193b0503950450adf
Autor:
Gabriel O. Resende, Thais S Barenco, Marcos T Couto, Thais Bazoti B. Sottani, Christina Maeda Takiya, Cristiano G Ponte, Antonio Carlos Carvalho, Fernando A.C. Seara, José Nascimento, Raiana A. Q. Barbosa, Natalia S C Souza, Ainá E. Domingos, Emanuelle F Baptista, Ana Paula Ferraz
Publikováno v:
Cardiovascular Drugs and Therapy. 35:719-732
In the present study, the therapeutic efficacy of a selective BKCa channel opener (compound X) in the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) was investigated. PAH was induced in male Wistar rats by a single inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e131dcde845055d9dfaa333d2263a22
https://doi.org/10.1007/s10557-020-07115-5
https://doi.org/10.1007/s10557-020-07115-5
Autor:
André M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimarães, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pâmella Dourila N. Souza, David William Provance, José Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecules; Volume 27; Issue 4; Pages: 1151
Universidade de São Paulo (USP)
instacron:USP
Molecules; Volume 27; Issue 4; Pages: 1151
The Piper species are a recognized botanical source of a broad structural diversity of lignans and its derivatives. For the first time, Piper tectoniifolium Kunth is presented as a promising natural source of the bioactive (−)-grandisin. Phytochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1db811a24f70d11dfefa29c5bcc2b5
Autor:
Ana Paula, Ferraz, Fernando A C, Seara, Emanuelle F, Baptista, Thais S, Barenco, Thais B B, Sottani, Natalia S C, Souza, Ainá E, Domingos, Raiana A Q, Barbosa, Christina M, Takiya, Marcos T, Couto, Gabriel O, Resende, Antonio C, Campos de Carvalho, Cristiano G, Ponte, Jose Hamilton M, Nascimento
Publikováno v:
Cardiovascular drugs and therapy. 35(4)
In the present study, the therapeutic efficacy of a selective BKPAH was induced in male Wistar rats by a single injection of MCT. After two weeks, the MCT-treated group was divided into two groups that were either treated with compound X or vehicle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5d043051eb18f176c7f966578f83387
https://pubmed.ncbi.nlm.nih.gov/33245463
https://pubmed.ncbi.nlm.nih.gov/33245463
Autor:
Adriano Norat Pinheiro, Paulo A. Melo, Fernando Chagas Patrão-Neto, Marcelo A. Strauch, Marcelo Oliveira Cesar, Cristiano G Ponte, José Roberto da Silva Rocha Junior, Pâmella Dourila Nogueira-Souza, Marcos Monteiro-Machado
Publikováno v:
Toxicon. 177:S12-S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1267ec88134d22930dcebbbc462244af
https://doi.org/10.1016/j.toxicon.2019.10.056
https://doi.org/10.1016/j.toxicon.2019.10.056
Autor:
Gabriel F. de Andrade, Cristiano G Ponte, Talita Menengat, Rafaela Teixeira, Bruno A. Cotrim, Wilson C. Santos, Gabriel O. Resende
Publikováno v:
Molecules, Vol 25, Iss 6, p 1467 (2020)
Molecules
Molecules
Quinazolinones have pharmacological effects on vascular reactivity through different mechanisms. We synthesized 4-phenylquinazolin-2(1H)-one derivatives under microwave irradiation and tested them on the rat thoracic aorta. The prepared compounds 2a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f62d4dcba1817541268d64c086718e
https://doi.org/10.3390/molecules25061467
https://doi.org/10.3390/molecules25061467
Autor:
Owen B. McManus, William A. Schmalhofer, Dong-Ming Shen, Sylvie M. Sur, Gregory J. Kaczorowski, Min Shu, Andra Stevenson, Tarak Shah, Maria L. Garcia, James B. Doherty, Ge Dai, Ravi P. Nargund, Guilherme Suarez-Kurtz, Cristiano G Ponte, Laszlo Kiss
Publikováno v:
Molecular Pharmacology. 81:567-577
High-conductance calcium-activated potassium (Maxi-K) channels are present in smooth muscle where they regulate tone. Activation of Maxi-K channels causes smooth muscle hyperpolarization and shortening of action-potential duration, which would limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129f1135576eb00877ce08849c2655a7
https://doi.org/10.1124/mol.111.075853
https://doi.org/10.1124/mol.111.075853
Autor:
Wilmar Dias da Silva, Cristiano G Ponte, Guilherme Suarez-Kurtz, Eduardo Lira Nóbrega, Vanessa C. Fernandes
Publikováno v:
Toxicon. 55:536-540
A murine model of venom-induced myotoxicity was used to assess the antimyotoxic capacity of a polyvalent antivenom (PAV), rich in F(ab')2 fragments, obtained from horses immunized with Bitis venoms. Intramuscular (i.m.) injection of Bitis rhinoceros,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52df5d1ab20f27ad6b2c4d0c5c18a8dc
https://doi.org/10.1016/j.toxicon.2009.10.006
https://doi.org/10.1016/j.toxicon.2009.10.006
Autor:
Megan Toups, Akiko Koide, Zoltan Takacs, Luis G. Cuello, Thomas F. Gajewski, Gregory Driessens, Erik C. B. Johnson, Eduardo Perozo, Shohei Koide, Guilherme Suarez-Kurtz, Matthew Biancalana, Steve A.N. Goldstein, Cristiano G Ponte, Astrid Kollewe
Publikováno v:
Proceedings of the National Academy of Sciences. 106:22211-22216
Venomous animals immobilize prey using protein toxins that act on ion channels and other targets of biological importance. Broad use of toxins for biomedical research, diagnosis, and therapy has been limited by inadequate target discrimination, for e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e7e57e3f10e1122bd38649ff17e032
https://doi.org/10.1073/pnas.0910123106
https://doi.org/10.1073/pnas.0910123106
Autor:
Owen B. McManus, Gloria C. Koo, Mary Jo Staruch, Mary Matyskiela, Randal M. Bugianesi, Markus Hanner, John P. Felix, William A. Schmalhofer, Denise Wunderler, B G Green, Robert S. Slaughter, Ana-Rosa Linde-Arias, Cristiano G. Ponte, Gregory J. Kaczorowski, Lucia Velasco, Kathleen M. Rupprecht, William H. Parsons, Shouwu Miao, Maria L. Garcia, Jianming Bao
Publikováno v:
Biochemistry. 41:7781-7794
The voltage-gated potassium channel, K(v)1.3, is a novel target for development of immunosuppressants. Using a functional (86)Rb(+) efflux assay, a new class of high-affinity K(v)1.3 inhibitors has been identified. The initial active in this series,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12018acfcca94b56fc83951d2d375b4
https://doi.org/10.1021/bi025722c
https://doi.org/10.1021/bi025722c