A phase I dose-escalation and pharmacokinetic study of a micellar nanoparticle with entrapped docetaxel (CPC634) in patients with advanced solid tumours

Autor: Catharine W Menke van der Houven van Oordt, Patrick Schöffski, Cristianne J.F. Rijcken, Rob Hanssen, Ron H.J. Mathijssen, Ferry A.L.M. Eskens, Herlinde Dumez, Florence Atrafi

Publikováno v: Journal of Controlled Release, 325, 191-197. Elsevier
Atrafi, F, Dumez, H, Mathijssen, R H J, Menke van der Houven van Oordt, C W, Rijcken, C J F, Hanssen, R, Eskens, F A L M & Schöffski, P 2020, ' A phase I dose-escalation and pharmacokinetic study of a micellar nanoparticle with entrapped docetaxel (CPC634) in patients with advanced solid tumours ', Journal of Controlled Release, vol. 325, pp. 191-197 . https://doi.org/10.1016/j.jconrel.2020.06.020

BACKGROUND: CPC634 is docetaxel entrapped in core-cross linked polymeric micelles. In preclinical studies, CPC634 demonstrated enhanced pharmacokinetics and improved therapeutic index. This phase I dose escalation study is the first-in-human study wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98410cefc7dc0212044e464899ceb916
https://doi.org/10.1016/j.jconrel.2020.06.020

TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Autor: Maarten Honing, Darya Hadavi, Matt Timmers, Tommi Meulemans, Jimmy Weterings, Rob M. J. Liskamp, Cristianne J.F. Rijcken, Harald Veldhuis, Hans Ippel

Publikováno v: Chemical Science
Chemical Science, 11(33), 9011-9016. Royal Society of Chemistry

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b44ad190e51f2e421aa1784b987eb2
https://doi.org/10.1039/d0sc03477k

Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges

Autor: Claudio Colombo, Eva Miriam Buhl, Mies J. van Steenbergen, Cristianne J.F. Rijcken, Tarun Ojha, Ruchi Bansal, Hiltrud Königs-Werner, Yang Shi, Mahsa Bagheri, Jan Wit, Michiel van Geijn, Gert Storm, Wim E. Hennink, Twan Lammers, Qizhi Hu

Publikováno v: Biotechnology Journal, 16(6). Wiley-VCH Verlag
Biotechnol J
Biotechnology journal, 16(6):2000212. Wiley-VCH Verlag
Biotechnology Journal

Background CriPec technology enables the generation of drug-entrapped biodegradable core-crosslinked polymeric micelles (CCPM) with high drug loading capacity, tailorable size, and drug release kinetics. Docetaxel (DTX)-entrapped CCPM, also referred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9791dd0952e11ab92d037835db8fd22
https://dspace.library.uu.nl/handle/1874/411685

First-in-human imaging of nanoparticle entrapped docetaxel (CPC634) in patients with advanced solid tumors using 89Zr-Df-CPC634 PET/CT

Autor: Marc C. Huisman, Iris Harriette Cornelia Miedema, Henk M.W. Verheul, Danielle J. Vugts, Daniela E. Oprea-Lager, Qizhi Hu, Cristianne J.F. Rijcken, Catharina Wilhelmina Menke, G.A.M.S. (Guus) van Dongen, G.J.C. Zwezerijnen, Ron H.J. Mathijssen

Publikováno v: Miedema, IHC, Zwezerijnen, GJC, Oprea-Lager, D, Verheul, HMW, Vugts, DJ, Huisman, MC, Mathijssen, R H J, Rijcken, C, Hu, Q, van Dongen, G & Menke, C W 2019, ' First-in-human imaging of nanoparticle entrapped docetaxel (CPC634) in patients with advanced solid tumors using 89Zr-Df-CPC634 PET/CT. ', Journal of Clinical Oncology, pp. 3093-3093 . https://doi.org/10.1200/JCO.2019.37.15_suppl.3093
Journal of Clinical Oncology, 3093-3093. American Society of Clinical Oncology
STARTPAGE=3093;ENDPAGE=3093;ISSN=0732-183X;TITLE=Journal of Clinical Oncology

3093 Background: CPC634 is a nanoparticle entrapping docetaxel designed to improve tumor accumulation and tolerability compared to conventionally administered docetaxel by taking advantage of the presumed enhanced permeability and retention (EPR) eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f31f5479b1ab01b4f824a523c56aadd
https://research.vumc.nl/en/publications/325a9246-6a67-4cde-b735-f8606d4ed53a

Polymeric Nanoparticles with Neglectable Protein Corona

Autor: Meike Schinnerer, Cristianne J.F. Rijcken, Christine Seidl, Matthias Barz, Twan Lammers, Stefan Tenzer, Mustafa Diken, Christian Leps, Diana Möckel, Michael Maskos, Irina Alberg, Svenja Morsbach, Natascha Drude, Katharina Landfester, Qizhi Hu, Stefan Kramer, Rudolf Zentel

Publikováno v: Small : nano micro 16(18), 1907574 (2020). doi:10.1002/smll.201907574
Small

Small : nano micro 16(18), 1907574 (2020). doi:10.1002/smll.201907574
Published by Wiley-VCH, Weinheim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d527e81797e34b0975046306c2594236
https://doi.org/10.1002/smll.201907574