NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses

Autor: Camila O.S. Souza, Natália Ketelut-Carneiro, Cristiane M. Milanezi, Lúcia H. Faccioli, Luiz G. Gardinassi, João S. Silva

Publikováno v: iScience, Vol 24, Iss 6, Pp 102548- (2021)

Summary: The recognition of fungi by intracellular NOD-like receptors (NLRs) induces inflammasome assembly and activation. Although the NLRC4 inflammasome has been extensively studied in bacterial infections, its role during fungal infections is uncl

Externí odkaz: https://doaj.org/article/8c953e87d780462f8f6d2c8bb1180761

Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs

Autor: Guilherme de Paula Costa, Laís Roquete Lopes, Maria Cláudia da Silva, Aline Luciano Horta, Washington Martins Pontes, Cristiane M. Milanezi, Paulo Marcos da Mata Guedes, Wanderson Geraldo de Lima, Richard Schulz, João Santana da Silva, Andre Talvani

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or no

Externí odkaz: https://doaj.org/article/21d650bccf554e7ab4ea31d8d648dea5

Prognostic value of sTREM-1 in COVID-19 patients: a biomarker for disease severity and mortality

Autor: Vinicius E Pimentel, Thais Fernanda de Campos Fraga-Silva, Angelo A.F. Junior, Marcelo Dias-Baruffi, Rita C.C. Barbieri, Elisa Maria de Sousa Russo, Rogério Serafim Parra, Kamila Zaparoli, Nicola T. Neto, Vania L. D. Bonato, Giovanna S. Porcel, Leticia F. Constant, Omar Féres, Cassia F. S. L. Dias, Fernando Crivelenti Vilar, Ana Paula Morais Fernandes, José Joaquim Ribeiro da Rocha, Fatima M. Ostini, Marley Ribeiro Feitosa, Caroline T. Garbato, Rafael C. da Silva, Augusto M. Degiovani, Fabiani Gai Frantz, Adriana Malheiro, Jamille Guedes Malta Argolo, Jonatan C S de Carvalho, Isabelle C. Guarneri, Malena M. Perez, Carlos Arterio Sorgi, Lilian Cataldi Rodrigues, Diana Mota Toro, Debora C. Nepomuceno, Ruxana T. Sadikot, Alessandro P de Amorim, Camilla Narjara Simão Oliveira, Cristina Ribeiro de Barros Cardoso, Dayane P. da Silva, Cristiane M. Milanezi, Lúcia Helena Faccioli, Pedro V da Silva Neto, Isabel Kinney Ferreira de Miranda Santos, Ana C. Xavier, Angelina Lettiere Viana, Ingryd Carmona-Garcia, Gilberto Gambero Gaspar, Sandra Regina Maruyama

BackgroundThe uncontrolled inflammatory response plays a critical role in the novel coronavirus disease (COVID-19) and triggering receptor expressed on myeloid cells-1 (TREM-1) is thought to be intricate to inflammatory signal amplification. This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da9aa1a5969983e6e3485d71142969a1
https://doi.org/10.1101/2020.09.22.20199703

Non-Leishmania Parasite in Fatal Visceral Leishmaniasis–like Disease, Brazil

Autor: Luana Aparecida Rogerio, Angela K. Cruz, Nayore T Takamiya, Viviane A Trombela, Caio A B Oliveira, Angela Maria da Silva, Sandra Regina Maruyama, Amélia Ribeiro de Jesus, João Santana da Silva, Cristiane M. Milanezi, Talita Y Takahashi, Roque P. Almeida, José M. C. Ribeiro, Aline Silva Barreto, Alynne Karen Mendonça de Santana

Publikováno v: Emerging Infectious Diseases, Vol 26, Iss 2, Pp 388-388 (2020)
Emerging infectious diseases
Emerging Infectious Diseases
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Emerging Infectious Diseases, Vol 25, Iss 11, Pp 2088-2092 (2019)

Through whole-genome sequencing analysis, we identified non-Leishmania parasites isolated from a man with a fatal visceral leishmaniasis–like illness in Brazil. The parasites infected mice and reproduced the patient’s clinical manifestations. Mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0150b6d3d5b9e36415e5fe008ccf5b
https://wwwnc.cdc.gov/eid/article/26/2/19-1428_article

Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis

Autor: João Santana da Silva, Camila O S Souza, Fabrine Sales Massafera Tristão, Natália Ketelut-Carneiro, Fernanda Agostini Rocha, Cristiane M. Milanezi, Daniela Carlos

Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology

Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis. The T helper 1-mediated immunity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47298612aaf12ee79046fd0edead094