Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Cristiane França, da Silva"'
1
Akademický článek
In vitro and in silico analysis of imatinib analogues as anti-Trypanosoma cruzi drug candidates
Autor: Luca S. F. Nesic de Freitas, Cristiane França da Silva, Sebastiano Intagliata, Emanuele Amata, Loredana Salerno, Maria de Nazaré Correia Soeiro
Publikováno v: Parasitology, Vol 150, Pp 359-364 (2023)
Chagas disease (CD) is a neglected tropical disease caused by the intracellular protozoan Trypanosoma cruzi that remains a serious public health issue affecting more than 6 million people worldwide. The available treatment includes 2 nitro derivative
Externí odkaz: https://doaj.org/article/36e506d37a524e1ea8f1bad73e87793d
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2
Akademický článek
Overexpression of TcNTPDase-1 Gene Increases Infectivity in Mice Infected with Trypanosoma cruzi
Autor: Natália Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane França da Silva, Denise da Gama Jaen Batista, Stênio Fragoso, Gabriel Melo de Oliveira, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 23, p 14661 (2022)
Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T. cruzi plasma membrane, which hydrolyze a wide range of tri-/-diphosphate nucleosides. In this work, we used previously developed genetically modi
Externí odkaz: https://doaj.org/article/ee0c666e8d554b9b80e43f753e64ee29
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3
Akademický článek
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
Autor: Daiane Dias Ferreira, Juliana Tonini Mesquita, Thais Alves da Costa Silva, Maiara Maria Romanelli, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Bruno Junior Neves, Cleber Camilo Melo-Filho, Maria de Nazare Correia Soeiro, Carolina Horta Andrade, Andre Gustavo Tempone
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-12 (2018)
Abstract Background Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods In this work, we studied the activity of the antidepressant drug sertraline against Trypanoso
Externí odkaz: https://doaj.org/article/5fea82da8c5541068b69e7ccd07d156e
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4
Akademický článek
Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection
Autor: Beatriz Philot Pavão, Kelly Cristina Demarque, Marcos Meuser Batista, Gabriel Melo de Oliveira, Cristiane França da Silva, Francisca Hildemagna Guedes da Silva, Luzia Fátima Gonçalves Caputo, Cynthia Machado Cascabulho, Marcello André Barcinski, Maria de Nazaré Correia Soeiro
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-20 (2018)
Abstract Background Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias. Our aim is to investi
Externí odkaz: https://doaj.org/article/655e6d8ff3b4408cafe1e242dd0d0b9d
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6
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies
Autor: Denise da Gama Jaen Batista, Alicia Gómez-Barrio, José Antonio Escario, Vicente J. Arán, Cristiane França da Silva, Maria de Nazaré Correia Soeiro, Raiza Brandão Peres, Gabriel Melo de Oliveira, A. S. G. Nefertiti, José Cumella, Marcos Meuser Batista, Cristina Fonseca-Berzal
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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In previous studies, we have identified several families of 5-nitroindazole derivatives as promising antichagasic prototypes. Among them, 1-(2-aminoethyl)-2-benzyl-5-nitro-1,2-dihydro-3H-indazol-3-one, (hydrochloride) and 1-(2-acetoxyethyl)-2-benzyl-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1118d1fa4a53698738b806b85c7610
https://doi.org/10.1017/s0031182020000955
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7
Akademický článek
The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
Autor: Cristiane França da Silva, Patrícia Bernadino da Silva, Marcos Meuser Batista, Anissa Daliry, Richard R Tidwell, Maria de Nazaré Correia Soeiro
Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 3, Pp 239-245 (2010)
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the avail
Externí odkaz: https://doaj.org/article/88ef7dce8e7149139b5cee2a304c4ef3
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9
Akademický článek
Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii.
Autor: Erica S Martins-Duarte, Faustine Dubar, Philippe Lawton, Cristiane França da Silva, Maria de Nazaré C Soeiro, Wanderley de Souza, Christophe Biot, Rossiane C Vommaro
Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125705 (2015)
Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a worldwide disease whose clinical manifestations include encephalitis and congenital malformations in newborns. Previously, we described the synthesis of new ethyl-ester derivatives of the
Externí odkaz: https://doaj.org/article/130a43e894414f2db6acdf90c3566db5
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