In Vitro and In Vivo Miltefosine Susceptibility of a Leishmania amazonensis Isolate from a Patient with Diffuse Cutaneous Leishmaniasis: Follow-Up.

Autor: Adriano C Coelho, Cristiana T Trinconi, Carlos H N Costa, Silvia R B Uliana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004720 (2016)

Externí odkaz: https://doaj.org/article/1ab387ffb4e44d24aaebd7efd5345560

Generation of luciferase-expressing Leishmania infantum chagasi and assessment of miltefosine efficacy in infected hamsters through bioimaging.

Autor: Juliana Q Reimão, Jordana C Oliveira, Cristiana T Trinconi, Paulo C Cotrim, Adriano C Coelho, Silvia R B Uliana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003556 (2015)

The only oral drug available for the treatment of leishmaniasis is miltefosine, described and approved for visceral leishmaniasis in India. Miltefosine is under evaluation for the treatment of cutaneous leishmaniasis in the Americas although its effi

Externí odkaz: https://doaj.org/article/fadedb336b324e0bb5c88a70efab4537

Antileishmanial activity of the estrogen receptor modulator raloxifene.

Autor: Juliana Q Reimão, Danilo C Miguel, Noemi N Taniwaki, Cristiana T Trinconi, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2842 (2014)

BACKGROUND: The treatment of leishmaniasis relies mostly on parenteral drugs with potentially serious adverse effects. Additionally, parasite resistance in the treatment of leishmaniasis has been demonstrated for the majority of drugs available, maki

Externí odkaz: https://doaj.org/article/5f8e018b6f5340e3b62bc16dd8a15517

Efficacy of tamoxifen and miltefosine combined therapy for cutaneous leishmaniasis in the murine model of infection withLeishmania amazonensis

Autor: Cristiana T. Trinconi, Juliana Quero Reimão, Adriano C. Coelho, Silvia R. B. Uliana

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

OBJECTIVES The objective of this study was to characterize in vitro interactions and evaluate the antileishmanial activity of tamoxifen and miltefosine combinations. METHODS Interactions between drugs were evaluated in vitro against Leishmania amazon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b8aeb54e85e79f50cf60d24db4cd1
https://doi.org/10.1093/jac/dkv495

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Autor: Chris Brown, John G. Mina, Ariel Mariano Silber, Norton Heise, Danilo C. Miguel, Paul W. Denny, Silvia R. B. Uliana, Cristiana T. Trinconi

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 475-487 (2018)
International journal for parasitology : drugs and drug resistance, 2018, Vol.8(3), pp.475-487 [Peer Reviewed Journal]
International Journal for Parasitology: Drugs and Drug Resistance

Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmania

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5739fe479d1356764767cba4fc89ffba