Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Cristian Trovato"'
1
Akademický článek
In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human
Autor: Leto Luana Riebel, Zhinuo Jenny Wang, Hector Martinez-Navarro, Cristian Trovato, Julia Camps, Lucas Arantes Berg, Xin Zhou, Ruben Doste, Rafael Sachetto Oliveira, Rodrigo Weber dos Santos, Jacopo Biasetti, Blanca Rodriguez
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Human-based modelling and simulation offer an ideal testbed for novel medical therapies to guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of heart failure and mortality, for which novel therapies are ur
Externí odkaz: https://doaj.org/article/07ce5339c7314d4ca4646c737d74cf59
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2
Akademický článek
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction
Autor: Cristian Trovato, Marcel Mohr, Friedemann Schmidt, Elisa Passini, Blanca Rodriguez
Publikováno v: Frontiers in Toxicology, Vol 4 (2022)
The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery. The ICH S7B Guideline and Q&A on Clinical and Nonclinical Evaluation of QT/QTc Interval Pro
Externí odkaz: https://doaj.org/article/51480fe6bfe54fbd80a1a0a0cdb1b93d
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3
Akademický článek
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
Autor: Annie Delaunois, Matthew Abernathy, Warren D. Anderson, Kylie A. Beattie, Khuram W. Chaudhary, Julie Coulot, Vitalina Gryshkova, Simon Hebeisen, Mark Holbrook, James Kramer, Yuri Kuryshev, Derek Leishman, Isabel Lushbough, Elisa Passini, Will S. Redfern, Blanca Rodriguez, Eric I. Rossman, Cristian Trovato, Caiyun Wu, Jean‐Pierre Valentin
Publikováno v: Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
Abstract We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsade
Externí odkaz: https://doaj.org/article/d703d6568c29415c8e2d93ccf47af5d0
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5
Simulated heterogeneity in purkinje-ventricular electrophysiology following acute myocardial infarction remodelling
Autor: B R Rodriguez, Cristian Trovato, Xin Zhou
Publikováno v: EP Europace. 23
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Wellcome Trust Senior Research Fellowship in Basic Biomedical Sciences Background Coronary heart disease is a common substrate for sudden cardiac death. Several cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa4f1618fba13e52eada0230b4f838bb
https://doi.org/10.1093/europace/euab116.538
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6
Applying the CiPA Approach to Evaluate Cardiac Proarrhythmia Risk of some Antimalarials Used Off‐label in the First Wave of COVID‐19
Autor: Isabel Lushbough, Jean-Pierre Valentin, Vitalina Gryshkova, Simon Hebeisen, Cristian Trovato, Will S. Redfern, Khuram W. Chaudhary, Caiyun Wu, Eric I. Rossman, Kylie A. Beattie, Julie Coulot, Elisa Passini, Yuri A. Kuryshev, Warren D. Anderson, Blanca Rodriguez, Annie Delaunois, Derek J. Leishman, Matthew M. Abernathy, James Kramer, Mark Holbrook
Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 3, Pp 1133-1146 (2021)
We applied a set of in silico and in vitro assays, compliant with the CiPA (Comprehensive In Vitro Proarrhythmia Assay) paradigm, to assess the risk of chloroquine or hydroxychloroquine‐mediated QT prolongation and Torsades de Pointes (TdP), alone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ff6229742ba87f71f81a342b9f06c
http://europepmc.org/articles/PMC8014548
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7
In-silico Trials for Drug Safety and Efficacy Assessment Using a Novel Human Purkinje Fibre Model
Autor: S. Billiald-Desquand, Elisa Passini, C. Dusserre, Cristian Trovato, Blanca Rodriguez
Publikováno v: CinC
In silico trials using multiscale and biophysically-detailed human models have proven to be a new powerful tool for proarrhythmic risk prediction. Our goal is to evaluate the consistency between in silico results using a novel human Purkinje model an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b225955d0b6bae4443e90bc74b8cf9e0
https://doi.org/10.22489/cinc.2020.361
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8
The virtual assay software for human in silico drug trials to augment drug cardiac testing
Autor: Oliver J. Britton, Blanca Rodriguez, Elisa Passini, Alfonso Bueno-Orovio, Cristian Trovato, Xin Zhou
Publikováno v: Journal of Computational Science
Prediction of drug effects on the heart still represents a challenge in drug development, given potential adverse outcomes. Computer modelling and simulations of the human heart offer a powerful technology to augment existing animal and clinical meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dcb63aaa5f14326723fd88bb8a95ec
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