Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Cristian O. Salas"'
Autor:
Thalia Delgado, Denisa Veselá, Hana Dostálová, Vladimír Kryštof, Veronika Vojáčková, Radek Jorda, Alejandro Castro, Jeanluc Bertrand, Gildardo Rivera, Mario Faúndez, Miroslav Strnad, Christian Espinosa-Bustos, Cristian O. Salas
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 649 (2024)
Bcr-Abl is an oncoprotein with aberrant tyrosine kinase activity involved in the progression of chronic myeloid leukemia (CML) and has been targeted by inhibitors such as imatinib and nilotinib. However, despite their efficacy in the treatment of CML
Externí odkaz:
https://doaj.org/article/6759ae3341e1454eb52b04d4fd0fb76d
Autor:
Claudia Gioé-Gallo, Sandra Ortigueira, José Brea, Iu Raïch, Jhonny Azuaje, M. Rita Paleo, Maria Majellaro, María Isabel Loza, Cristian O. Salas, Xerardo García-Mera, Gemma Navarro, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114934- (2023)
Synthetic cannabinoid receptor agonists (SCRAs) constitute the largest and most defiant group of abuse designer drugs. These new psychoactive substances (NPS), developed as unregulated alternatives to cannabis, have potent cannabimimetic effects and
Externí odkaz:
https://doaj.org/article/3b0ddeb6be494b4382e24224b8f69591
Autor:
Cesar Echeverría, Aldo Martin, Felipe Simon, Cristian O. Salas, Mariajesus Nazal, Diego Varela, Ramón A. Pérez-Castro, Juan F. Santibanez, Ricardo O. Valdés-Valdés, Oscar Forero-Doria, Javier Echeverría
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: There is abundant ethnopharmacological evidence the uses of regarding Solanum species as antitumor and anticancer agents. Glycoalkaloids are among the molecules with antiproliferative activity reported in these species.Purpose: To evaluat
Externí odkaz:
https://doaj.org/article/ded390d9bcbc4197b0bf58cb25b3f7ed
Autor:
Ileana Araque, Javiera Ramírez, Rut Vergara, Jaime Mella, Pablo Aránguiz, Luis Espinoza, Waleska Vera, Iván Montenegro, Cristian O. Salas, Joan Villena, Mauricio A. Cuellar
Publikováno v:
Molecules, Vol 28, Iss 9, p 3959 (2023)
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were syn
Externí odkaz:
https://doaj.org/article/78f76b6b627d42d7b2bb87e75d18d898
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 2233-2244 (2020)
Three 2-arylpiperidinyl-1,4-naphthoquinone derivatives were synthesized and evaluated in vitro to determine their cytotoxicity on cancer and normal cell lines. In order to establish their possible action mechanism, the electrochemical behaviour of th
Externí odkaz:
https://doaj.org/article/e105db318c7f4ac2a62a8a2aff7d4c4f
Autor:
Álvaro Cañete-Molina, Christian Espinosa-Bustos, Marcos González-Castro, Mario Faúndez, Jaime Mella, Ricardo A. Tapia, Alan R. Cabrera, Iván Brito, Adam Aguirre, Cristian O. Salas
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1092-1107 (2019)
We synthesized two new series of 3-substituted-6-(2,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines and analysed them for a potential role as antitumor agents. Twenty-two compounds were obtained, and four molecular structures were determined by X-ray diff
Externí odkaz:
https://doaj.org/article/62245047d055465aa15eb2b1a71e58a5
Autor:
Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Alejandro Castro-Alvarez, Jaime Mella, David Cabezas, Mario Faúndez, Christian Espinosa-Bustos, Cristian O. Salas
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1294 (2022)
We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structur
Externí odkaz:
https://doaj.org/article/e164559cd3e445158c0980316b7a2f9f
Autor:
Christian Espinosa-Bustos, Luisa Leitzbach, Tito Añazco, María J. Silva, Andrea del Campo, Alejandro Castro-Alvarez, Holger Stark, Cristian O. Salas
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 573 (2022)
Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives. These compounds are designe
Externí odkaz:
https://doaj.org/article/0731fa894f9e4929b5457508023a33af
Autor:
Christian Espinosa-Bustos, Mariana Ortiz Pérez, Alonzo Gonzalez-Gonzalez, Ana María Zarate, Gildardo Rivera, Javier A. Belmont-Díaz, Emma Saavedra, Mauricio A. Cuellar, Karina Vázquez, Cristian O. Salas
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1121 (2022)
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of Trypanosoma cruzi
Externí odkaz:
https://doaj.org/article/bbb4bd96a47e4581b9ab2d5f9e1a5fdd
Autor:
Ana María Zárate, Christian Espinosa-Bustos, Simón Guerrero, Angélica Fierro, Felipe Oyarzún-Ampuero, Andrew F. G. Quest, Lucia Di Marcotullio, Elena Loricchio, Miriam Caimano, Andrea Calcaterra, Matías González-Quiroz, Adam Aguirre, Jaime Meléndez, Cristian O. Salas
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8372 (2021)
The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists having the versatile pur
Externí odkaz:
https://doaj.org/article/f044d22d327c48a68b213c4f941cf2ce