Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells

Autor: María Macarena Massip-Copiz, Mariángeles Clauzure, Ángel G. Valdivieso, María Ángeles Aguilar, Consuelo Mori, Tomás A. Santa-Coloma, Cristian J A Asensio

Publikováno v: Postprint de artículo publicado en Biochemistry and Cell Biology. 2021, 99 (4)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Cystic fibrosis (CF) is caused by mutations in the CFTR gene. It has been postulated that a reduced HCO3 − transport in CF through CFTR may lead to a decreased airway surface liquid (ASL) pH. In contrast, others have reported no changes in the extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3452890939cbdbdba8d607be4bbd0038
https://pubmed.ncbi.nlm.nih.gov/33481676

Impairment of CFTR activity in cultured epithelial cells upregulates the expression and activity of LDH resulting in lactic acid hypersecretion

Autor: Mariángeles Clauzure, María M. Massip-Copiz, Cristian J. A. Asensio, Carla E. Cancio, Consuelo Mori, Tomás A. Santa-Coloma, Ángel G. Valdivieso

Publikováno v: Cellular and Molecular Life Sciences. 2019, 76
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Mutations in the gene encoding the CFTR chloride channel produce cystic fbrosis (CF). CF patients are more susceptible to bacterial infections in lungs. The most accepted hypothesis sustains that a reduction in the airway surface liquid (ASL) volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382cfef6734e5ef1deebbc9953f5c6d9
https://repositorio.uca.edu.ar/handle/123456789/9596