Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cristian Gonzalez-Colin"'
Autor:
Meghana Pagadala, Timothy J. Sears, Victoria H. Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James V. Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Shervin Goudarzi, Divya Kirani, Jessica Au, Tongwu Zhang, Teresa Landi, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip Pravin Patel, Ludmil B. Alexandrov, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun Chieh Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here, we study 1084
Externí odkaz:
https://doaj.org/article/1886eb37a6cb4e559bd4787806656c26
Autor:
Benjamin J. Schmiedel, Job Rocha, Cristian Gonzalez-Colin, Sourya Bhattacharyya, Ariel Madrigal, Christian H. Ottensmeier, Ferhat Ay, Vivek Chandra, Pandurangan Vijayanand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Immune cells are important in the pathogenesis of COVID-19. Here the authors assessed the effects of COVID-19-risk variants on gene expression in a range of immune cell types, highlighting their potential to impact the function of diverse immune cell
Externí odkaz:
https://doaj.org/article/1849316b872d4746b6e5d01562162e4d
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants
Autor:
Pandurangan Vijayanand, Pejman Mohammadi, Cristian Gonzalez-Colin, Stephanie Fotsing, Bjoern Peters, Grégory Seumois, Sourya Bhattacharyya, Austin Crinklaw, Ferhat Ay, Ariel Madrigal, Vivek Chandra, Mitchell Kronenberg, Benjamin J Schmiedel
Publikováno v:
Nat Genet
Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis-reg
Autor:
Meghana Pagadala, Victoria Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Timothy Sears, Shervin Goudarzi, Divya Kirani, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip P. Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun C. Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
Publikováno v:
Cancer Research. 82:3825-3825
With the continued promise of immunotherapy as an avenue for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer risk screening and treatment strategies. Using geno
Autor:
Meghana Pagadala, Victoria H. Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Timothy Sears, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Shervin Goudarzi, Divya Kirani, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip Pravin Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun Chieh Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
With the continued promise of immunotherapy as an avenue for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Approaches that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf07db06ead15937314b56d9cf8badf
https://doi.org/10.1101/2021.04.14.436660
https://doi.org/10.1101/2021.04.14.436660
Autor:
Ferhat Ay, Job Rocha, Christian H. Ottensmeier, Ariel Madrigal, Pandurangan Vijayanand, Vivek Chandra, Sourya Bhattacharyya, Cristian Gonzalez-Colin, Benjamin J Schmiedel
Publikováno v:
Nature Communications
NATURE COMMUNICATIONS
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
NATURE COMMUNICATIONS
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Given the importance of immune cells in the pathogenesis of COVID-19 illness, here we assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033e8f3d75bf55dcd8eaa992f2296c17
https://doi.org/10.1101/2020.12.01.407429
https://doi.org/10.1101/2020.12.01.407429
Knowledge extraction for assisted curation of summaries of bacterial transcription factor properties
Autor:
Carlos-Francisco Méndez-Cruz, Socorro Gama-Castro, Antonio Blanchet, Ignacio Arroyo-Fernández, Alan Godínez, Cristian Gonzalez-Colin, Sara Martínez-Luna, Julio Collado-Vides
Publikováno v:
Database: The Journal of Biological Databases and Curation
Transcription factors (TFs) play a main role in transcriptional regulation of bacteria, as they regulate transcription of the genetic information encoded in DNA. Thus, the curation of the properties of these regulatory proteins is essential for a bet
Autor:
Hyo Kim, Rany M. Salem, J. Silvio Gutkind, Wes Thompson, Steven Cao, Benjamin J Schmiedel, Meghana Pagadala, Andrea Castro, Cristian Gonzalez-Colin, Victoria Wu, Vijayanand Pandurangan, Hannah Carter
Publikováno v:
Cancer Research. 81:828-828
Developing effective therapies to intervene in the tumor immune evasion process is a challenge further complicated by interindividual variability in tumor-host immunological interactions. Germline variation is a major component of interindividual var
Autor:
Vivek Chandra, Sourya Bhattacharyya, Benjamin J. Schmiedel, Ariel Madrigal, Cristian Gonzalez-Colin, Stephanie Fotsing, Mitchell Kronenberg, Bjoern Peters, Ferhat Ay, Pandurangan Vijayanand
Publikováno v:
The Journal of Immunology. 204:145.36-145.36
Expression quantitative trait loci (eQTLs) studies have provided associations with gene expression for many non-coding genetic variants associated with human disease and evolution. However, they fail to pinpoint the functionally important eQTLs or pr