Výsledky vyhledávání - "Cristian Dobrota"

Glycine Fluoromethylketones as SENP-Specific Activity Based Probes

Autor: Cristina Pop, Gheorghe-Doru Roiban, Ioana Dumitru, Niculina D. Hădade, Guy S. Salvesen, Veronika M. Meier, Domenico Fasci, Mihaela Matache, Cristian Dobrota, Daniel P. Funeriu

Publikováno v: ChemBioChem. 13:80-84

We report here the synthesis and biochemical properties of a new peptidyl activity-based probe 1 for SUMO proteases, SENPs. The activity-based probe has at its C terminus a glycine-derived fluoromethylketone moiety as a reactive group designed to tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25993eefe4a08da0c2c0d853cf8c6551
https://doi.org/10.1002/cbic.201100645

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Synthesis of fused dihydro-pyrimido[4,3-d]coumarins using Biginelli multicomponent reaction as key step

Autor: Cristian Dobrota, Niculina D. Bogdan, Ileana C. Farcasanu, Ion Baciu, Lavinia L. Ruta, Daniel P. Funeriu, Ioana Dumitru, Codruta C. Paraschivescu, Mihaela Matache

Publikováno v: Tetrahedron. 65:5949-5957

A new efficient approach for the synthesis of functionalized dihydro-pyrimido[4,3-d]coumarins is described. Use of benzyl- or tert-butyl acetoacetate and various salicyl aldehydes in typical Biginelli multicomponent reactions provides esters that can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3f28687405daa4fd05812777c2c8269
https://doi.org/10.1016/j.tet.2009.05.088

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New non-symmetrical 2,5-disubstituted-1,3,4-oxadiazoles bearing a benzo[b]thiophene moiety

Autor: Constantin Draghici, Codruţa C. Paraschivescu, Lavinia L. Ruţă, Cristian Dobrota, Ion Baciu, Florea Dumitrascu, Mihaela Matache

Publikováno v: ARKIVOC, Vol 2008, Iss 13, Pp 198-206 (2008)
Scopus-Elsevier

A series of new 2,5-disubstituted-1,3,4-oxadiazoles derived from benzo[b]thiophene was obtained by dehydrative cyclization of the corresponding N,N’-diacylhydrazines, in presence of an excess of phosphorous oxychloride. The structures of the new sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f71a9f3cbe95e39033d2eb15524fed4
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0009.d22

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Synthesis of Enantiopure 1-r-Alkyl-2-c,5-t-Diphenylphospholanes and Phospholanium Salts through Direct Alkylation of Phospholane

Autor: Jean-Claude Fiaud, Amelie Duraud, Martial Toffano, Cristian Dobrota

Publikováno v: European Journal of Organic Chemistry. 2008:2439-2445

Chiral enantiopure 1-alkyl-2,5-diphenylphospholanium salts were obtained in one step through alkylation of phospholane with alkyl triflates. The resulting air-stable phosphonium salts are electron-rich trialkylphosphane precursor ligands for transiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9f75e930400593c1940e36227b3d000
https://doi.org/10.1002/ejoc.200800070

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Electrochemical and spectroscopic characterization and catalytic activity of Co(II) complexes of tetra-chloro-R-Salen ([tClSalen=bis(3,5-di-chloro-α-R salicylidene)ethylenediamine]) and tetra-chloro-R-Salophen ([tClSalophen=bis(3,5-di-chloro-α-R salicylidene)-1,2-phenylenediamine]), R=H, CH3, CH2-CH3

Autor: Aurel Pui, Cristian Dobrota, Jean-Pierre Mahy

Publikováno v: Journal of Coordination Chemistry. 60:581-595

A series of 3,5-tetra-chloro-R-Salen and 3,5-tetra-chloro-R-Salophen Co(II) complexes, (where R = H, CH3, and CH2-CH3; Salen is bis(salicylaldehyde)ethylenediimine; and Salophen is bis(salicylaldehyde) N,N′-o-phenylendiimine) have been obtained. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0227b03ad73ad31403c649fb82ec6fa2
https://doi.org/10.1080/00958970600894980

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Chiral 1,2,5-triphenylphospholanium tetrafluoroborate as ligand precursor in Rh-catalyzed asymmetric hydrogenation of methyl (Z)-2-acetamidocinnamate

Autor: Cristian Dobrota, Jean-Claude Fiaud, Martial Toffano

Publikováno v: Tetrahedron Letters. 45:8153-8156

( S , S )-1,2,5-Triphenylphospholanium tetrafluoroborate salt 2 was conveniently used as chiral ligand precursor in rhodium-catalyzed asymmetric hydrogenation of methyl ( Z )-2-acetamidocinnamate. 31 P NMR showed the existence of a solvent-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0a954fd11b1624fef07b91bc0176d6e
https://doi.org/10.1016/j.tetlet.2004.09.031

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Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess–Martin reagent

Autor: Ion Baciu, Codruţa C. Paraschivescu, Ioana Dumitru, Lavinia L. Ruţă, Cristian Dobrota, Mihaela Matache

Publikováno v: Tetrahedron Letters. 50:1886-1888

2,5-Disubstituted 1,3,4-oxadiazoles have been conveniently prepared by oxidative cyclization of N -acyl- N′ -aryliden-hydrazines promoted by an excess of Dess–Martin periodinane under mild conditions (23 examples, up to 92% isolated yields).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4ff93ae9acc3e1384ad75d9aa51d211
https://doi.org/10.1016/j.tetlet.2009.02.054

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Unexpected formation of N-(1-(2-aryl-hydrazono)isoindolin-2-yl)benzamides and their conversion into 1,2-(bis-1,3,4-oxadiazol-2-yl)benzenes

Autor: Ileana C. Farcasanu, Cristian Dobrota, Alina Nicolescu, Catalin Maxim, Niculina D. Hădade, Mihaela Matache, Calin Deleanu, Codruta C. Paraschivescu

Publikováno v: The Journal of organic chemistry. 78(6)

Reaction between ortho-phthalaldehyde and various aroylhydrazines unexpectedly yields N-(1-(2-aryl-hydrazono)isoindolin-2-yl)benzamides as major products along with the predictable 1,2-bis-aroylhydrazones. NMR investigation of the major reaction prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2caf0c7db4574bf9cadb83b7acc63bd
https://pubmed.ncbi.nlm.nih.gov/23394598

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