Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Crista D. Thomas"'
Autor:
Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 981-994 (2019)
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://doaj.org/article/09be2b3fa76c4660b95ac736ad3c5f60
Autor:
Medhanie E. Kidane, Boden H. Vanderloop, Wenxu Zhou, Crista D. Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W. David Nes
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2310-2323 (2017)
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) th
Externí odkaz:
https://doaj.org/article/c5dd241f6f744dcebd1bd6c255049167
Autor:
Emilio Ramos, Juqiang Yan, Minu Chaudhuri, Paxtyn M. Fisher, W. David Nes, Ujjal K. Singha, Medhanie E. Kidane, Crista D. Thomas, Michael T. Nagel, Xunlu Zhu, Wenxu Zhou, Boden H. Vanderloop
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 981-994 (2019)
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a972613f0c255aa6aa0b0cfd9238363
https://doi.org/10.1194/jlr.m091587
https://doi.org/10.1194/jlr.m091587
Autor:
W. David Nes, Andrew G. S. Warrilow, Boden H. Vanderloop, Steven L. Kelly, Crista D. Thomas, Wenxu Zhou, Emilio Ramos, Paxtyn M. Fisher, Claire L. Price, Diane E. Kelly, Josie E. Parker, Michael D. Loftis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863:1164-1178
The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to Δ(8,14)-sterol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a01aeb7b2cfd1d5d9540c0a88dfe952
https://doi.org/10.1016/j.bbalip.2018.07.004
https://doi.org/10.1016/j.bbalip.2018.07.004
Autor:
Boden H. Vanderloop, Minu Chaudhuri, Ujjal K. Singha, W. David Nes, Medhanie E. Kidane, Crista D. Thomas, Wenxu Zhou, Emilio Ramos
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 12, Pp 2310-2323 (2017)
Journal of Lipid Research, Vol 58, Iss 12, Pp 2310-2323 (2017)
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2291560a65e5aad48f3da017b3c3df7d
http://europepmc.org/articles/PMC5711494
http://europepmc.org/articles/PMC5711494
Autor:
william David Nes, Minu Chaudhuri, Wenxu Zhou, Sudha Neelam, Boden H. Vanderloop, Amelia A. Gillespie, Jerry Y. Niederkorn, Crista D. Thomas, Ujjal K. Singha
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1421e1354e479da824f7e0ab7daf4cd
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.15
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.15
Autor:
Brad A. Haubrich, T. Thuy Minh Nguyen, W. David Nes, Crista D. Thomas, Presheet Patkar, Ming Qi
Publikováno v:
Biochemical Journal. 456:253-262
The tightly coupled nature of the electrophilic alkylation reaction sequence catalysed by 24-SMT (sterol C-24-methyltransferase) of land plants and algae can be distinguished by the formation of cationic intermediates that yield phyla-specific produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b30d0c60743aa338dfe5981a0297bbe
https://doi.org/10.1042/bj20121818
https://doi.org/10.1042/bj20121818
Autor:
Matthew B. Miller, Qian Wang, William J. Snell, Stephanie K. Pleasant, Emily K. Collins, Brad A. Haubrich, Crista D. Thomas, W. David Nes, Alicia L. Howard
Publikováno v:
Phytochemistry. 113
Sterol C24-methyltransferases (SMTs) constitute a group of sequence-related proteins that catalyze the pattern of sterol diversity across eukaryotic kingdoms. The only gene for sterol alkylation in green algae was identified and the corresponding cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d0273a01694a2eb3e7adc2d719e29d
https://pubmed.ncbi.nlm.nih.gov/25132279
https://pubmed.ncbi.nlm.nih.gov/25132279