Zobrazeno 1 - 10
of 12 439
pro vyhledávání: '"Crispr-Cas9"'
Autor:
Daniel J. Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A. Haeusser, Jens D. Maile, Aaron Stahl, Mohamed A. Jarboui, Anna Lechado-Terradas, Franziska Klose, Sepideh Babaei, Jakob Admard, Nicolas Casadei, Cristiana Roggia, Michael Spohn, Jens Schittenhelm, Stephan Singer, Ulrich Schüller, Federica Piccioni, Nicole S. Persky, Manfred Claassen, Marcos Tatagiba, Philipp J. Kahle, David E. Root, Markus Templin, Ghazaleh Tabatabai
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-38 (2024)
Abstract Background Atypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Despite intensive research efforts, the prognosis for ATRT patients under currently established treatment protocols is poor. While novel the
Externí odkaz:
https://doaj.org/article/c3f097f8f86b4c4a8b8f3ec94c994ed5
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 75-83 (2024)
The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders and cance
Externí odkaz:
https://doaj.org/article/1f6ad6d9de6e420c85787ccc287042b0
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 537-548 (2024)
CRISPR-Cas9 systems constitute bacterial adaptive immune systems that protect against phage infections. Bacteriophages encode anti-CRISPR proteins (Acrs) that mitigate the bacterial immune response. However, the structural basis for their inhibitory
Externí odkaz:
https://doaj.org/article/b211b8426df24a8f9f5b82c1cada2f21
Autor:
Rahul Kumar, Sankar Prasad Das, Burhan Uddin Choudhury, Amit Kumar, Nitish Ranjan Prakash, Ramlakhan Verma, Mridul Chakraborti, Ayam Gangarani Devi, Bijoya Bhattacharjee, Rekha Das, Bapi Das, H. Lembisana Devi, Biswajit Das, Santoshi Rawat, Vinay Kumar Mishra
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-23 (2024)
Abstract Conventional pre-genomics breeding methodologies have significantly improved crop yields since the mid-twentieth century. Genomics provides breeders with advanced tools for whole-genome study, enabling a direct genotype–phenotype analysis.
Externí odkaz:
https://doaj.org/article/d62676a93f7042e494e09d8d8a92759f
Publikováno v:
The EuroBiotech Journal, Vol 8, Iss 4, Pp 213-229 (2024)
The precise prediction of off-target effects in CRISPR-Cas9 genome editing is critical for ensuring the safety and efficacy of this powerful tool. This study leverages machine learning techniques to predict off-target cleavage sites and investigate t
Externí odkaz:
https://doaj.org/article/e723cd04e3354f1f92a28023e9e5ba80
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Conditional regulation is a highly beneficial system for studying the function of essential genes in Plasmodium falciparum and dimerizable Cre recombinase (DiCre) is a recently adapted conditional regulation system suitable for this purpose.
Externí odkaz:
https://doaj.org/article/847f659377b945b3bc401aa5f7bcb01b
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Heterosis is a common phenomenon in plants and has been extensively applied in crop breeding. However, the superior traits in the hybrids can only be maintained in the first generation but segregate in the following generations. M
Externí odkaz:
https://doaj.org/article/61e6e9c24bee483dbb68264f22aa4aa6
Autor:
Javier Poyatos-García, Patricia Soblechero-Martín, Alessandro Liquori, Andrea López-Martínez, Pilar Maestre, Elisa González-Romero, Rafael P. Vázquez-Manrique, Nuria Muelas, Gema García-García, Jessica Ohana, Virginia Arechavala-Gomeza, Juan J. Vílchez
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Background Gene editing therapies in development for correcting out-of-frame DMD mutations in Duchenne muscular dystrophy aim to replicate benign spontaneous deletions. Deletion of 45–55 DMD exons (del45–55) was described in asymptomatic
Externí odkaz:
https://doaj.org/article/04805daa00ca464381398824273732b2
Publikováno v:
Сибирский онкологический журнал, Vol 23, Iss 4, Pp 152-161 (2024)
Purpose of the study: analysis of modern scientific data on the molecular mechanisms of the CRISPR-Cas9 system in gene editing, advantages and disadvantages in cancer research and the development of new treatment methods. Material and Methods. A comp
Externí odkaz:
https://doaj.org/article/681c2cc948994722aec234a6c8a53871
Autor:
Yu C. J. Chey, Mark A. Corbett, Jayshen Arudkumar, Sandra G. Piltz, Paul Q. Thomas, Fatwa Adikusuma
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The development of sequence-specific precision treatments like CRISPR gene editing therapies for Duchenne muscular dystrophy (DMD) requires sequence humanized animal models to enable the direct clinical translation of tested strat
Externí odkaz:
https://doaj.org/article/dcea31a8dfee493680c161e9f4f7c5c9