Zobrazeno 1 - 10
of 755
pro vyhledávání: '"Crispin, J."'
Autor:
Eva C. Freckmann, Emma Sandilands, Erin Cumming, Matthew Neilson, Alvaro Román-Fernández, Konstantina Nikolatou, Marisa Nacke, Tamsin R. M. Lannagan, Ann Hedley, David Strachan, Mark Salji, Jennifer P. Morton, Lynn McGarry, Hing Y. Leung, Owen J. Sansom, Crispin J. Miller, David M. Bryant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
There are currently a lack of tools to detect heterogeneity in 3D cultures. Here the authors report Traject3d as a framework to identify heterogeneous states in 3D culture and to understand how these give rise to distinct phenotypes using label-free
Externí odkaz:
https://doaj.org/article/d1ea5c3909d0472cb9c9c41a696d4ec5
A model of k-mer surprisal to quantify local sequence information content surrounding splice regions
Publikováno v:
PeerJ, Vol 8, p e10063 (2020)
Molecular sequences carry information. Analysis of sequence conservation between homologous loci is a proven approach with which to explore the information content of molecular sequences. This is often done using multiple sequence alignments to suppo
Externí odkaz:
https://doaj.org/article/c6f890ee67d44d59b6a444a2f4c4411e
Akademický článek
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Autor:
Catharine M.L. West, Johannes H.A.M. Kaanders, Adrian L. Harris, Francesca M. Buffa, Peter J. Hoskin, Ana M. Rojas, Jarrod J. Homer, Crispin J. Miller, Helen Denley, Guy N.J. Betts, Janet Taylor, Joely J. Irlam, Paul N. Span, Navin Mani, Amanda Eustace
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2a54d6f1972363229a55ea31deee62
https://doi.org/10.1158/1078-0432.22447830
https://doi.org/10.1158/1078-0432.22447830
Autor:
Catharine M.L. West, Johannes H.A.M. Kaanders, Adrian L. Harris, Francesca M. Buffa, Peter J. Hoskin, Ana M. Rojas, Jarrod J. Homer, Crispin J. Miller, Helen Denley, Guy N.J. Betts, Janet Taylor, Joely J. Irlam, Paul N. Span, Navin Mani, Amanda Eustace
Purpose: Tumor hypoxia is associated with a poor prognosis, hypoxia modification improves outcome, and hypoxic status predicts benefit from treatment. Yet, there is no universal measure of clinical hypoxia. The aim of this study was to investigate wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aeb80d19a2e3ec31a934dcd3c29203
https://doi.org/10.1158/1078-0432.c.6521229
https://doi.org/10.1158/1078-0432.c.6521229
Autor:
John Brognard, Crispin J. Miller, Andrew Biankin, Paul Lorigan, Phil Chapman, Shameem Fawdar, Eleanor W. Trotter, Yaoyong Li, Tim Yates, Andrew M. Hudson
Supplementary Table 1A. Mutations that were only identified by CCLE in the comparison of sequencing data of 1630 genes across 568 cell lines from CCLE and COSMIC . Supplementary Table 1B. Mutations that were only identified by COSMIC in the compariso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477c004054a6e2e888ecc1d71015b0c9
https://doi.org/10.1158/0008-5472.22403805.v1
https://doi.org/10.1158/0008-5472.22403805.v1
Autor:
John Brognard, Crispin J. Miller, Andrew Biankin, Paul Lorigan, Phil Chapman, Shameem Fawdar, Eleanor W. Trotter, Yaoyong Li, Tim Yates, Andrew M. Hudson
Groovy program script used to make the 568 cell line comparison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10218ed93068d3180cc18b0413cf3173
https://doi.org/10.1158/0008-5472.22403808.v1
https://doi.org/10.1158/0008-5472.22403808.v1
Autor:
John Brognard, Crispin J. Miller, Andrew Biankin, Paul Lorigan, Phil Chapman, Shameem Fawdar, Eleanor W. Trotter, Yaoyong Li, Tim Yates, Andrew M. Hudson
Supplementary Figure 1. Original comparison of 18 cell lines sequenced by COSMIC and CCLE to display that the conformity of missense mutation detection ranges from 56.75% in HCC2218 cell line to 12.90% in HCC1954. Supplementary Figure 2. Bamfile imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3c0381b05292a138f2b264532cc32c
https://doi.org/10.1158/0008-5472.22403814.v1
https://doi.org/10.1158/0008-5472.22403814.v1
Autor:
John Brognard, Owen J. Sansom, Tony Hunter, Crispin J. Miller, Ewelina Testoni, Matthew Collier, Ross Overman, Isabelle Green, Chris Phillips, Hannah K. Pollard, Claire Brassington, Jon A. Read, Lorena A. Puto, Phil Chapman, Susan Mason, Karen Blyth, Yaoyong Li, Eleanor W. Trotter, Hayeon Baik, Natalie L. Stephenson, Anna A. Marusiak
Supplementary methods. Figure S1. (related to Fig. 1A-F) Analysis of mutations of MLK4 and MLK1 present in CRC cells. Figure S2 (related to Fig. 2 and 3) Structural analysis of MLK4 mutants. Figure S3 (related to Fig. 2 and 3) Structural analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912
https://doi.org/10.1158/0008-5472.22409912
Autor:
Alvaro Román-Fernández, Mohammed A. Mansour, Fernanda G. Kugeratski, Jayanthi Anand, Emma Sandilands, Laura Galbraith, Kai Rakovic, Eva C. Freckmann, Erin M. Cumming, Ji Park, Konstantina Nikolatou, Sergio Lilla, Robin Shaw, David Strachan, Susan Mason, Rachana Patel, Lynn McGarry, Archana Katoch, Kirsteen J. Campbell, Colin Nixon, Crispin J. Miller, Hing Y. Leung, John Le Quesne, James C. Norman, Sara Zanivan, Karen Blyth, David M. Bryant
Publikováno v:
Science Advances. 9
The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and po