Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Crisbel M. Artuz"'
Autor:
Crisbel M. Artuz, Alexander J. Knights, Alister P.W. Funnell, Thomas J. Gonda, Katya Ravid, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley
Publikováno v:
Biotechnology Reports, Vol 20, Iss , Pp - (2018)
The ability of transcriptional regulators to drive lineage conversion of somatic cells offers great potential for the treatment of human disease. To explore the concept of switching on specific target genes in heterologous cells, we developed a model
Externí odkaz:
https://doaj.org/article/3c543b0157ad430fb8b1f643e413d8f4
Autor:
Timothy J. Molloy, Ernst J. Wolvetang, Melinda L. Tursky, David D.F. Ma, Helen Tao, Suad Alateeq, To Ha Loi, Crisbel M. Artuz
Publikováno v:
Stem Cell Reports
Summary Induced pluripotent stem cells (iPSCs) are an invaluable resource for the study of human disease. However, there are no standardized methods for differentiation into hematopoietic cells, and there is a lack of robust, direct comparisons of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747e89915675680b11916934fdb484a2
https://doi.org/10.1016/j.stemcr.2020.07.009
https://doi.org/10.1016/j.stemcr.2020.07.009
Autor:
Merlin Crossley, Richard C. M. Pearson, Alexander J. Knights, Thomas J. Gonda, Crisbel M. Artuz, Kate G. R. Quinlan, Katya Ravid, Alister P. W. Funnell
Publikováno v:
Biotechnology Reports, Vol 20, Iss, Pp-(2018)
Biotechnology Reports
Biotechnology Reports
Highlights • GATA1 and FLI1 switch on the endogenous platelet factor 4 (Pf4) gene in fibroblasts. • Pf4 expression is maintained and increases over time. • PF4 protein is secreted and readily collected. • A new technology for the g0065neratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd9677d3e7f889a55bc5a1a1847fd6a
http://www.sciencedirect.com/science/article/pii/S2215017X18301668
http://www.sciencedirect.com/science/article/pii/S2215017X18301668
Autor:
Wooi F. Lim, Richard C. M. Pearson, Alister P. W. Funnell, Merlin Crossley, Ka Sin Mak, Crisbel M. Artuz, Jon Burdach, Lit Yeen Tan, Beeke Wienert
Publikováno v:
Nucleic Acids Research
Transcription factors (TFs) are often regarded as being composed of a DNA-binding domain (DBD) and a functional domain. The two domains are considered separable and autonomous, with the DBD directing the factor to its target genes and the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3f9f743aabe6174cbcd20fd6bd6ea7
http://europepmc.org/articles/PMC3874204
http://europepmc.org/articles/PMC3874204
Autor:
Alister P. W. Funnell, Douglas R. Higgs, Wooi F. Lim, Gabriella E. Martyn, Richard C. M. Pearson, Kate G. R. Quinlan, Crisbel M. Artuz, Jon Burdach, Ka Sin Mak, Emma Whitelaw, Douglas Vernimmen, Beeke Wienert, Merlin Crossley
Publikováno v:
Funnell, A P, Vernimmen, D, Lim, W F, Mak, K S, Wienert, B, Martyn, G E, Artuz, C M, Burdach, J, Quinlan, K G, Higgs, D R, Whitelaw, E, Pearson, R C & Crossley, M 2014, ' Differential regulation of the alpha-globin locus by Kruppel-like factor 3 in erythroid and non-erythroid cells ', BMC Molecular Biology, vol. 15, no. 1, pp. 8 . https://doi.org/10.1186/1471-2199-15-8
BMC Molecular Biology
BMC Molecular Biology
Background: Krüppel-like Factor 3 (KLF3) is a broadly expressed zinc-finger transcriptional repressor with diverse biological roles. During erythropoiesis, KLF3 acts as a feedback repressor of a set of genes that are activated by Krüppel-like Facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a753751d6e2348f3f528a0b2e860fe60
https://ora.ox.ac.uk/objects/uuid:4c819e33-0ecd-4b0f-96d5-4d8ad3033a98
https://ora.ox.ac.uk/objects/uuid:4c819e33-0ecd-4b0f-96d5-4d8ad3033a98
Autor:
Ka Sin Mak, Jose Perdomo, Philip Koh, Natalie A. Twine, Crisbel M. Artuz, Stuart H. Orkin, Stuart T. Fraser, Tzong-Tyng Hung, Alister P. W. Funnell, Richard C. M. Pearson, Marc R. Wilkins, Laura J. Norton, Jon Burdach, Carl Power, Andrew C. Perkins, Merlin Crossley, Kim S. Bell-Anderson
The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes. We have previously shown that EKLF drives transcription of the gene for a second KLF, basic K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c69184bbced390318f9c277594e33
https://europepmc.org/articles/PMC3434552/
https://europepmc.org/articles/PMC3434552/
Autor:
Noelia Nunez, Alister P. W. Funnell, Josep Font, Merlin Crossley, Joel P. Mackay, Marylène Vandevenne, Crisbel M. Artuz, Kate G. R. Quinlan, Samantha Hallal, Richard C. M. Pearson, Molly M.K. Clifton, Surya Setiyaputra
Publikováno v:
The Journal of biological chemistry. 286(44)
Classical C2H2 zinc finger proteins are among the most abundant transcription factors found in eukaryotes, and the mechanisms through which they recognize their target genes have been extensively investigated. In general, a tandem array of three fing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f74a1205d523439e78920d9f6eaf8c9
https://pubmed.ncbi.nlm.nih.gov/21908891
https://pubmed.ncbi.nlm.nih.gov/21908891