Výsledky vyhledávání - "Crisanto Guadiz"

Strategies to develop highly drug-tolerant cell-based neutralizing antibody assay: neutralizing antidrug antibodies extraction and drug depletion

Autor: Alexander Fichtner, Carlos Cabrera Ruiz, Crisanto Guadiz, Boris Gorovits, Minlei Zhang, John Kamerud, Zhihua Jiang

Publikováno v: Bioanalysis. 12:1279-1293

Aim: Drug interference poses great analytical challenges for cell-based neutralizing antidrug antibodies (NAb) assay. The work aimed to improve assay drug tolerance through biotin-drug extraction with acid dissociation method optimization and develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c11a4ed277f00f451a996557cb58e20
https://doi.org/10.4155/bio-2020-0091

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Addressing soluble target interference in the development of a functional assay for the detection of neutralizing antibodies against a BCMA-CD3 bispecific antibody

Autor: Crisanto Guadiz, Boris Gorovits, Michael Luong, Ying Wang, Minlei Zhang

Publikováno v: Journal of Immunological Methods. 474:112642

Proper evaluation of immunogenicity during clinical development of biotherapeutics is a major challenge to bioanalytical scientists, in part due to matrix interference in anti-drug antibody (ADA) and neutralizing antibody (NAB) assays. If not address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd938ebbd5ee2eec4ad8f7ae365892f
https://doi.org/10.1016/j.jim.2019.112642

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