Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Cris S Constantinescu"'
Autor:
Abiodun M Noah, Jennie Spendlove, Zhanhan Tu, Frank Proudlock, Cris S Constantinescu, Irene Gottlob, Dorothee P Auer, Rob A Dineen, Iain K Moppett
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0305964 (2024)
IntroductionPostoperative delirium in older people may result from the interaction between intrinsic brain vulnerability (e.g. neurodegeneration) and precipitating factors (e.g. surgery induced cytokines). Intrinsic brain vulnerability may be overt (
Externí odkaz:
https://doaj.org/article/bc99874fcba94bd9bd4e0e1cfa9ceb3e
Autor:
Kimberley Allen-Philbey, Stefania De Trane, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy MacDougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S Constantinescu, Catherine Dalton, Rachel A Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Emma C Tallantyre, Stewart Webb, Benjamin P Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 14 (2021)
Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak ® ) in multiple sclerosis (MS) patients. Methods: Litak ® was offered to MS-patients irrespective of disease course. Litak ® 10 mg was administered for 3–4 days d
Externí odkaz:
https://doaj.org/article/bfd4d711187c4be1bbc0bfb3a0440750
Autor:
Nadina B Lincoln, Lucy E Bradshaw, Cris S Constantinescu, Florence Day, Avril ER Drummond, Deborah Fitzsimmons, Shaun Harris, Alan A Montgomery, Roshan das Nair
Publikováno v:
Health Technology Assessment, Vol 24, Iss 4 (2020)
Background: People with multiple sclerosis have problems with memory and attention. The effectiveness of cognitive rehabilitation has not been established. Objectives: The objectives were to assess the clinical effectiveness and cost-effectiveness of
Externí odkaz:
https://doaj.org/article/2dc09e4adf184bdf9c323baeb70c540b
Autor:
Elena Morandi, Radu Tanasescu, Rachael E Tarlinton, Cris S Constantinescu, Weiya Zhang, Christopher Tench, Bruno Gran
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172415 (2017)
BACKGROUND:The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. O
Externí odkaz:
https://doaj.org/article/f370a1389c6549329fc74ae972ec8c23
Publikováno v:
Biomedical Journal, Vol 37, Iss 2, Pp 41-49 (2014)
This article reviews and discusses the approved and emerging therapies for multiple sclerosis (MS). MS is a chronic and disabling immune-mediated disease of the central nervous system (CNS) that affects mainly young adults. MS imposes a huge economic
Externí odkaz:
https://doaj.org/article/e62514f09276412c9d0ebc8e23071dbe
Publikováno v:
Biomedical Journal, Vol 37, Iss 2, Pp 50-59 (2014)
Pediatric multiple sclerosis (MS) represents only 2-5% of the MS population, but children with MS have a higher relapse rate and reach permanent disability at a younger age than adult-onset MS. Early and accurate diagnosis of pediatric MS is vital fo
Externí odkaz:
https://doaj.org/article/ff7ba0a0de81420a96b6d4acde6065b0
Autor:
Cris S Constantinescu, Bruno Gran
Publikováno v:
Biomedical Journal, Vol 37, Iss 2, Pp 34-40 (2014)
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which destruction of myelin and nerve axons has been shown to be mediated by immune mechanisms. Although the focus of research has been traditionally on T ce
Externí odkaz:
https://doaj.org/article/0093575a29f04ab18d05a61e6559ec21
Autor:
Christopher R Tench, Radu Tanasescu, Dorothee P Auer, William J Cottam, Cris S Constantinescu
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106735 (2014)
Coordinate based meta-analysis (CBMA) is used to find regions of consistent activation across fMRI and PET studies selected for their functional relevance to a hypothesis. Results are clusters of foci where multiple studies report in the same spatial
Externí odkaz:
https://doaj.org/article/7e47a589d5b643c5af7ab471391e5702
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70143 (2013)
Coordinate based meta-analysis (CBMA) is widely used to find regions of consistent activation across fMRI studies that have been selected for their functional relevance to a given hypothesis. Only reported coordinates (foci), and a model of their spa
Externí odkaz:
https://doaj.org/article/3ab78bcaa4214c7e83896bd0a6fb2490
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e44942 (2012)
Episodic memory impairment is a common but poorly-understood phenomenon in multiple sclerosis (MS). We aim to establish the relative contributions of reduced integrity of components of the extended hippocampal-diencephalic system to memory performanc
Externí odkaz:
https://doaj.org/article/bc1221672cc1478abdaa45961118d7be