Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Cris M. Welling"'
Autor:
Katsuya Tanabe, Yang Liu, Syed D Hasan, Sara C Martinez, Corentin Cras-Méneur, Cris M Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J Rhodes, Erik Zmuda, Tsonwin Hai, Nada A Abumrad, M Alan Permutt
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18146 (2011)
The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apoptosis and t
Externí odkaz:
https://doaj.org/article/b671a558826147669c4f27ffce82fc99
Autor:
Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W Doble, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Morris F White, Ernesto Bernal-Mizrachi, James R Woodgett, M Alan Permutt
Publikováno v:
PLoS Biology, Vol 6, Iss 2, p e37 (2008)
Despite treatment with agents that enhance beta-cell function and insulin action, reduction in beta-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by impaired signaling th
Externí odkaz:
https://doaj.org/article/204fb8f76a4a4489839e941e516b46eb
Autor:
Szabolcs Fatrai, M. A. Permutt, Ernesto Bernal-Mizrachi, R. E. Schmidt, Pedro Luis Herrera, A. C. Riggs, Cris M. Welling, J. Wasson, John Murray, Mitsuru Ohsugi
Publikováno v:
Diabetologia, Vol. 48, No 11 (2005) pp. 2313-2321
AIMS/HYPOTHESIS: Wolfram syndrome is an autosomal recessive disorder characterised by childhood diabetes mellitus, optic atrophy and severe neurodegeneration, resulting in premature death. The aim of this study was to investigate the mechanisms respo
Autor:
Christopher J. Rhodes, Syed D. Hasan, M. Alan Permutt, Erik Zmuda, Corentin Cras-Méneur, Cris M. Welling, Yang Liu, Nada A. Abumrad, Sara C. Martinez, Yukio Tanizawa, Ernesto Bernal-Mizrachi, Katsuya Tanabe, Tsonwin Hai
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18146 (2011)
PLoS ONE
PLoS ONE
Background The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apop
Publikováno v:
Proceedings of the National Academy of Sciences. 88:7294-7297
A human liver glucokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) cDNA was isolated from a liver cDNA library. This cDNA (hLGLK1) appeared to be full length [2548 base pairs (bp) plus additional poly(A) residues], as its size was consistent w
Autor:
Corentin Cras-Méneur, Katsuya Tanabe, Cris M. Welling, Zhonghao Liu, Satish Patel, Ernesto Bernal-Mizrachi, James R. Woodgett, M. Alan Permutt, Lin Li, Sara C. Martinez, Morris F. White, Bradley W. Doble
Publikováno v:
PLoS Biology, Vol 6, Iss 2, p e37 (2008)
PLoS Biology
PLoS Biology
Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by impaired signaling throug
Publikováno v:
ResearcherID
Aims/hypothesis. AKT1, a serine/threonine protein kinase, is an important downstream target of the insulin-signalling pathway, with both anti-apoptotic and peripheral metabolic effects. Because impaired insulin signalling is a major hallmark of Type