Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cris M. Brown"'
Autor:
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram
Externí odkaz:
https://doaj.org/article/24a5fd515d1d461683a1b821a7ee0008
Autor:
Damien Abreu, Stephen I. Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, Cris M. Brown, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess A. Marshall, Tamara Hershey, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and roden
Externí odkaz:
https://doaj.org/article/cc59812ac3294482ac751139a8922e28
Autor:
Takuya Yagi, Cris M. Brown, Simin Lu, Fumihiko Urano, Jana Mahadevan, Damien Abreu, Kohsuke Kanekura, Shuntaro Morikawa
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Endoplasmic reticulum (ER) stress-mediated cell death is an emerging target for human chronic disorders, including neurodegeneration and diabetes. However, there is currently no treatment for preventing ER stress-mediated cell death. Here, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a4178c88c3cabafbe73677193704a3
https://doi.org/10.1038/s41374-020-0436-1
https://doi.org/10.1038/s41374-020-0436-1
Autor:
Ashley N Simpson, Damien Abreu, Toni S. Pearson, Hongjie Gu, Tamara Hershey, Neil H. White, Gregory P. Van Stavern, James Hoekel, Stacy Hurst, Robert C. Bucelli, Chinyere Onwumere, Cris M. Brown, Bess A. Marshall, Stephen I. Stone, Fumihiko Urano, Kelly Kries, Lawrence Tychsen
Publikováno v:
JCI Insight.
BACKGROUNDWolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and rodent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edd7c99fdbfd313a376062271daaae6
https://doi.org/10.1172/jci.insight.145188
https://doi.org/10.1172/jci.insight.145188
Autor:
Jiawen Liang, Lalitha Venkaraman, Geidy E. Serrano, Fumihiko Urano, Peter Davies, Sulev Kõks, Nancy E. Hernandez Villegas, Marc I. Diamond, Cris M. Brown, Karen Duff, Yoshi Nakano, Hongjun Fu, Thomas G. Beach, Shuo Chen
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1f9228fb03ab5b5adac7fda54de94a
https://doi.org/10.1002/alz.042085
https://doi.org/10.1002/alz.042085
Autor:
Damien, Abreu, Stephen I, Stone, Toni S, Pearson, Robert C, Bucelli, Ashley N, Simpson, Stacy, Hurst, Cris M, Brown, Kelly, Kries, Chinyere, Onwumere, Hongjie, Gu, James, Hoekel, Lawrence, Tychsen, Gregory P, Van Stavern, Neil H, White, Bess A, Marshall, Tamara, Hershey, Fumihiko, Urano
Publikováno v:
JCI Insight
BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and roden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5250eadabd7d799a0ccdbfeff589a267
https://pubmed.ncbi.nlm.nih.gov/34185708
https://pubmed.ncbi.nlm.nih.gov/34185708
Autor:
Neil H. White, Toni S. Pearson, Stacy Hurst, Hongjie Gu, Tamara Hershey, Ashley N Simpson, Lawrence Tychsen, Cris M. Brown, Kelly Kries, James Hoekel, Damien Abreu, Bess A. Marshall, Stephen I. Stone, Fumihiko Urano, Robert C. Bucelli, Gregory P. Van Stavern
BackgroundWolfram syndrome is a rare endoplasmic reticulum disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is currently no treatment to delay, halt, or reverse the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb70672123fe31e0eed6b81fc5615a0f
https://doi.org/10.1101/2020.10.07.20208694
https://doi.org/10.1101/2020.10.07.20208694
Autor:
Takuya Yagi, Shuntaro Morikawa, Kohsuke Kanekura, Cris M. Brown, Damien Abreu, Fumihiko Urano, Jana Mahadevan
Publikováno v:
Diabetes. 68
Endoplasmic reticulum (ER) stress is an emerging target for human chronic disorders, including β cell death in type 1 and type 2 diabetes, as well as neurodegenerative diseases. However, there is currently no treatment for preventing ER stress-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9f9268346173bc31cf3dc4ba9051f9
https://doi.org/10.2337/db19-345-lb
https://doi.org/10.2337/db19-345-lb
Autor:
Kelly Kries, Stephen I. Stone, Gregory P. Van Stavern, Ashley N Simpson, Cris M. Brown, Bess A. Marshall, Robert C. Bucelli, Fumihiko Urano, Neil H. White, Damien Abreu, Toni S. Pearson, Lawrence Tychsen, Hongjie Gu, Tamara Hershey
Publikováno v:
Diabetes. 68
Wolfram syndrome is a rare, progressive neurodegenerative disorder characterized by juvenile-onset diabetes, optic nerve atrophy and mutation of the WFS1 gene. Calcium dyshomeostasis is a key mechanism underlying neuronal and pancreatic β-cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a415a53068261e2aeed707dca5168fe
https://doi.org/10.2337/db19-85-lb
https://doi.org/10.2337/db19-85-lb
Publikováno v:
Diabetes. 67
Endoplasmic reticulum (ER) homeostasis is crucial for proper β-cell function as evidenced by rare monogenic diabetic disorders, such as Wolfram syndrome, arising from genetic defects in key ER molecules. Wolfram syndrome stems from mutation of the E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7f787d032fc5e80aa25b7710bb9046
https://doi.org/10.2337/db18-2114-p
https://doi.org/10.2337/db18-2114-p