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Akademický článek

A digital assay for programmed death-ligand 1 (22C3) quantification combined with immune cell recognition algorithms in non-small cell lung cancer

Autor: Will Paces, Elliott Ergon, Elizabeth Bueche, G. Dave Young, Vitria Adisetiyo, Cris Luengo, Meredith James, Charles Caldwell, Dannah Miller, Morgan Wambaugh, Geoffrey Metcalf, Roberto Gianani

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract PD-L1 (22C3) checkpoint inhibitor therapy represents a mainstay of modern cancer immunotherapy for non-small cell lung cancer (NSCLC). In vitro diagnostic (IVD) PD-L1 antibody staining is widely used to predict clinical intervention efficacy

Externí odkaz: https://doaj.org/article/fcfbd68415114c36b101185dfdc94015

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Abstract 3879: Image analysis-based identification and quantification of macrophages in PD-L1 (22C3) stained NSCLC tissue sections without additional macrophage-specific staining

Autor: Will Paces, Rebecca Kim, Huong Nguyen, Roberto Gianani, Michael Argyres, Cris Luengo, Charles W. Caldwell, Bradley Long

Publikováno v: Cancer Research. 80:3879-3879

PD-L1 positivity in tumor-associated macrophages has been related to a favorable response to anti-PD-1 and PD-L1 targeted therapies. This concept has driven interest in specifically identifying macrophages in PD-L1 stained tissues, but pathologists o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45782050dfbf79da8c612c9715ac01fe
https://doi.org/10.1158/1538-7445.am2020-3879

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Abstract 4918: Artificial intelligence-assisted macrophage identification in tumor biopsies

Autor: Kelsey Weigel, Will Paces, Elliott Ergon, Jeni Caldara, Kile McFadden, Cris Luengo, Roberto Gianani, Bharathi Vennapusa

Publikováno v: Cancer Research. 79:4918-4918

Understanding response to immunotherapy requires accurate and complete characterization of tumor-associated immune cells in order to fully contextualize the immuno-oncology biomarker expression. Current standard practices surrounding enumeration of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6191b2dd8319456946d7641825e70dc3
https://doi.org/10.1158/1538-7445.am2019-4918

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Identifying all individuals in a honeybee hive : progress towards mapping all social interactions

Autor: Cris Luengo Hendriks, Ziquan Yu, Antoine Lecocq, Teatske Bakker, Barbara Locke, Olle Terenius

Publikováno v: University of Copenhagen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::809ea99c7f2c4c2bc8e8d8c8b4a42be7
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188544

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