Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue

Autor: Francine Parker, Anna A. S. Tang, Brendan Rogers, Glenn Carrington, Cris dos Remedios, Amy Li, Darren Tomlinson, Michelle Peckham

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

Dilated Cardiomyopathy is a common form of heart failure. Determining how this disease affects the structure and organization of cardiomyocytes in the human heart is important in understanding how the heart becomes less effective at contraction. Here

Externí odkaz: https://doaj.org/article/cc6a0c4d5c4f4d3485748c72de4d581d

TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Autor: Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, Hua Xiao, Hugo A Katus, Johann Bauersachs, Oliver J Müller, Joerg Heineke

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-20 (2019)

Abstract Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is n

Externí odkaz: https://doaj.org/article/f9470b276260446599ccfd463aeb960b

Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D

Autor: Melissa Herwig, Detmar Kolijn, Mária Lódi, Soraya Hölper, Árpád Kovács, Zoltán Papp, Kornelia Jaquet, Peter Haldenwang, Cris Dos Remedios, Peter H. Reusch, Andreas Mügge, Marcus Krüger, Jens Fielitz, Wolfgang A. Linke, Nazha Hamdani

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertro

Externí odkaz: https://doaj.org/article/6c6cfd0482f04fd7bfbaae9b047f2698

Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Autor: Joanne A. Groeneveldt, Christophe Guignabert, Rowan Smal, Samara M.A. Jansen, Berend E. Westerhof, Peter Dorfmüller, Frances S. de Man, Frank P. T. Oosterveer, Anne Keogh, Harm Jan Bogaard, Annemieke C. Heijboer, Marie-José Goumans, Lilian J. Meijboom, Anton Vonk Noordegraaf, M. Louis Handoko, Hans W.M. Niessen, Olaf Mercier, A. Josien Smits, Cathelijne Emma van der Bruggen, Jessie Van Wezenbeek, Marc Humbert, Joost W. van Leeuwen, J. Tim Marcus, Aida Llucià-Valldeperas, Cris dos Remedios

Publikováno v: Journal of Heart and Lung Transplantation, 41(4), 445-457. Elsevier USA
Journal of heart and lung transplantation, 41(4), 445-457. Elsevier USA
The Journal of Heart and Lung Transplantation
The Journal of Heart and Lung Transplantation, 2021, Online ahead of print. ⟨10.1016/j.healun.2021.11.004⟩
Journal of Heart and Lung Transplantation. Elsevier USA
van Wezenbeek, J, Groeneveldt, JA, Llucià Valldeperas, A, van der Bruggen, CEE, Jansen, SMA, Smits, AJ, Smal, R, van Leeuwen, J W, dos Remedios, C, Keogh, A, Humbert, M, Dorfmuller, P, Mercier, O, Guignabert, C, Niessen, JWM, Handoko, ML, Marcus, JT, Meijboom, LJ, Oosterveer, F P T, Westerhof, BE, Heijboer, AC, Bogaard, HJ, Vonk-Noordegraaf, A, Goumans, M-J T H & de Man, FS 2021, ' Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort ', Journal of Heart and Lung Transplantation . < https://www.jhltonline.org/article/S1053-2498(21)02581-X/fulltext >
van Wezenbeek, J, Groeneveldt, J A, Llucià-Valldeperas, A, van der Bruggen, C E, Jansen, S M A, Smits, A J, Smal, R, van Leeuwen, J W, Remedios, C D, Keogh, A, Humbert, M, Dorfmüller, P, Mercier, O, Guignabert, C, Niessen, H W M, Handoko, M L, Marcus, J T, Meijboom, L J, Oosterveer, F P T, Westerhof, B E, Heijboer, A C, Bogaard, H J, Noordegraaf, A V, Goumans, M J & de Man, F S 2022, ' Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort ', Journal of Heart and Lung Transplantation, vol. 41, no. 4, pp. 445-457 . https://doi.org/10.1016/j.healun.2021.11.004
Journal of Heart and Lung Transplantation, 41(4), 445-457. ELSEVIER SCIENCE INC

BACKGROUND: To investigate the association between altered sex hormone expression and long-term right ventricular (RV) adaptation and progression of right heart failure in a Dutch cohort of Pulmonary Arterial Hypertension (PAH)-patients across a wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4dd802a7c4895dedb51dcb85dea6d9
https://research.vumc.nl/en/publications/adf739fe-a8b8-412a-880f-03a44d45aa95

Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies

Autor: Sean Lal, James W. McNamara, Amy Li, Cris dos Remedios, Zijun Ge

Publikováno v: Heart Failure Reviews. 24:743-758

Heart failure represents the end result of different pathophysiologic processes, which culminate in functional impairment. Regardless of its aetiology, the presentation of heart failure usually involves symptoms of pump failure and congestion, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494ee95c2aa88e5f1fe316cd86cc0a04
https://doi.org/10.1007/s10741-019-09806-0