Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Crilles Casper Larsen"'
Autor:
Henusha D. Jhundoo, Tobias Siefen, Alfred Liang, Christoph Schmidt, John Lokhnauth, Brice Moulari, Arnaud Béduneau, Yann Pellequer, Crilles Casper Larsen, Alf Lamprecht
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100080- (2021)
Findings from recent studies revealed a significant anti-inflammatory effect of polysaccharide-based excipients when formulated with classical drugs in experimental inflammatory bowel disease models. In this study, acacia and guar gum were investigat
Externí odkaz:
https://doaj.org/article/2f2136603913494b8b192fdd2f881e1e
Autor:
Henusha D. Jhundoo, Tobias Siefen, Alfred Liang, Christoph Schmidt, John Lokhnauth, Arnaud Béduneau, Yann Pellequer, Crilles Casper Larsen, Alf Lamprecht
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1038 (2020)
Chitosan is used in various drug delivery approaches as a pharmaceutical excipient. Although its potential as an immunomodulatory agent has been reported, its use in this capacity has not been fully explored. The efficacy of chitosan as an active pha
Externí odkaz:
https://doaj.org/article/a189f8ca14e54ff3bcab13326943efe6
Autor:
Tobias Siefen, John Lokhnauth, Brice Moulari, Yann Pellequer, Alfred Chi-Yeh Liang, Crilles Casper Larsen, Alf Lamprecht, Arnaud Béduneau, Henusha D. Jhundoo, Christoph Schmidt
Publikováno v:
Biomolecules & Therapeutics
5-amino salicylic acid (5-ASA) is a standard therapy for the treatment of mild to moderate forms of inflammatory bowel diseases (IBD) whereas more severe forms involve the use of steroids and immunosuppressive drugs. Hyaluronic acid (HA) is a natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aa3e8694ee24aba36f27cfdf5b6064
https://doi.org/10.4062/biomolther.2020.227
https://doi.org/10.4062/biomolther.2020.227
Publikováno v:
Journal of Controlled Release. 332:581-591
Estimation of joint residence time of a drug is a key requirement for rational development of intraarticular therapeutics. There is a great need for a predictive model to reduce the high number of animal experiments in early stage development. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f4fe79cbfa247a77cd6bb8259a8c95
https://doi.org/10.1016/j.jconrel.2021.03.008
https://doi.org/10.1016/j.jconrel.2021.03.008
Autor:
Crilles Casper Larsen, Kevin E. Driscoll, Alison Bendele, Alfred Chi-Yeh Liang, John Lokhnauth, Faizan Niazi
Publikováno v:
Journal of Experimental Orthopaedics, Vol 7, Iss 1, Pp 1-11 (2020)
Journal of Experimental Orthopaedics
Journal of Experimental Orthopaedics
Purpose Intraarticular (IA) hyaluronic acid (HA) injection is used to reduce pain and improve mobility in knee osteoarthritis (OA). Little is known about histopathological changes underlying HA efficacy. This study investigated dose-related effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1919382ff57de89fd70137d7b8b6a9
http://link.springer.com/article/10.1186/s40634-020-00256-4
http://link.springer.com/article/10.1186/s40634-020-00256-4
Autor:
Brice Moulari, Alf Lamprecht, Christoph Schmidt, Crilles Casper Larsen, Tobias Siefen, Arnaud Béduneau, Yann Pellequer, Henusha D. Jhundoo, Alfred Chi-Yeh Liang, John Lokhnauth
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100080-(2021)
Findings from recent studies revealed a significant anti-inflammatory effect of polysaccharide-based excipients when formulated with classical drugs in experimental inflammatory bowel disease models. In this study, acacia and guar gum were investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a861268efee106b7a0a794c1e930330
https://pubmed.ncbi.nlm.nih.gov/33997765
https://pubmed.ncbi.nlm.nih.gov/33997765
Autor:
Jesper Østergaard, Mette Høg Gaunø, Thomas Vilhelmsen, Jorgen Wittendorff, Jukka Rantanen, Johan Boetker, Crilles Casper Larsen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 83:49-56
The purpose of this study was to investigate the in vitro release of 5-aminosalicylic acid from single extrudates by UV imaging and to explore the technique as a visualization tool for detecting film coating defects on extrudates coated with a thin e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f8f48543f9faf7c8e6f744f2b627a5
https://doi.org/10.1016/j.jpba.2013.04.028
https://doi.org/10.1016/j.jpba.2013.04.028
Autor:
Jorgen Wittendorff, Jukka Rantanen, Thomas Vilhelmsen, Mette Høg Gaunø, Crilles Casper Larsen, Jørn Møller-Sonnergaard
Publikováno v:
Pharmaceutical Development and Technology. 18:926-934
Pharmaceutically relevant material characteristics are often analyzed based on univariate descriptors instead of utilizing the whole information available in the full distribution. One example is droplet size distribution, which is often described by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad826d0ecc9aa8cbb4095f98eb5b64f2
https://doi.org/10.3109/10837450.2011.619542
https://doi.org/10.3109/10837450.2011.619542
Publikováno v:
Powder Technology. 183:213-219
The source of variation in the full scale processability of 131 batches of the active pharmaceutical ingredient 5-aminosalicylic acid was investigated. The variation in processability, seen in the amount of granulation liquid needed for extrusion, wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd1f4dd8b48ed6a2898332f00c12c0ac
https://doi.org/10.1016/j.powtec.2007.07.042
https://doi.org/10.1016/j.powtec.2007.07.042
Publikováno v:
Pharmaceutical Development and Technology. 6:181-192
The purpose of the experiments in this paper was to evaluate granulation end-point control by power consumption measurement in a 25-L high shear mixer. The effect of impeller design, impeller speed, liquid addition rate, type of binder, and mixing ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96e5f164052b67f918b64dd7cd961fe
https://doi.org/10.1081/pdt-100000739
https://doi.org/10.1081/pdt-100000739