Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Cribbs AP"'
Autor:
Cribbs, AP, Perera, SMW
Publikováno v:
The Yale Journal of Biology and Medicine
Since its emergence in 2012, the genome editing technique known as CRISPR-Cas9 and its scientific use have rapidly expanded globally within a very short period of time. The technique consists of using an RNA guide molecule to bind to complementary DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::51a15435f8ce2b71cd249cf0d2e76eec
https://ora.ox.ac.uk/objects/uuid:377b67ec-61e6-444d-afa7-d5f133529797
https://ora.ox.ac.uk/objects/uuid:377b67ec-61e6-444d-afa7-d5f133529797
Autor:
Cribbs, AP, Kennedy, A, Penn, H, Read, JE, Amjadi, P, Green, P, Syed, K, Manka, SW, Brennan, FM, Gregory, B, Williams, RO
OBJECTIVE: Functionally impaired Treg cells expressing abnormally low levels of CTLA-4 have been well documented in rheumatoid arthritis (RA). However, the molecular defect underlying this reduced expression is unknown. The aims of this study were to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b6e63ec12659a9855bf1c2bcccb5c6de
https://doi.org/10.1002/art.38715
https://doi.org/10.1002/art.38715
Autor:
David J. Ahern, Zhichao Ai, Mark Ainsworth, Chris Allan, Alice Allcock, Brian Angus, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Dominik Aschenbrenner, Moustafa Attar, J. Kenneth Baillie, Eleanor Barnes, Rachael Bashford-Rogers, Archana Bashyal, Sally Beer, Georgina Berridge, Amy Beveridge, Sagida Bibi, Tihana Bicanic, Luke Blackwell, Paul Bowness, Andrew Brent, Andrew Brown, John Broxholme, David Buck, Katie L. Burnham, Helen Byrne, Susana Camara, Ivan Candido Ferreira, Philip Charles, Wentao Chen, Yi-Ling Chen, Amanda Chong, Elizabeth A. Clutterbuck, Mark Coles, Christopher P. Conlon, Richard Cornall, Adam P. Cribbs, Fabiola Curion, Emma E. Davenport, Neil Davidson, Simon Davis, Calliope A. Dendrou, Julie Dequaire, Lea Dib, James Docker, Christina Dold, Tao Dong, Damien Downes, Hal Drakesmith, Susanna J. Dunachie, David A. Duncan, Chris Eijsbouts, Robert Esnouf, Alexis Espinosa, Rachel Etherington, Benjamin Fairfax, Rory Fairhead, Hai Fang, Shayan Fassih, Sally Felle, Maria Fernandez Mendoza, Ricardo Ferreira, Roman Fischer, Thomas Foord, Aden Forrow, John Frater, Anastasia Fries, Veronica Gallardo Sanchez, Lucy C. Garner, Clementine Geeves, Dominique Georgiou, Leila Godfrey, Tanya Golubchik, Maria Gomez Vazquez, Angie Green, Hong Harper, Heather A. Harrington, Raphael Heilig, Svenja Hester, Jennifer Hill, Charles Hinds, Clare Hird, Ling-Pei Ho, Renee Hoekzema, Benjamin Hollis, Jim Hughes, Paula Hutton, Matthew A. Jackson-Wood, Ashwin Jainarayanan, Anna James-Bott, Kathrin Jansen, Katie Jeffery, Elizabeth Jones, Luke Jostins, Georgina Kerr, David Kim, Paul Klenerman, Julian C. Knight, Vinod Kumar, Piyush Kumar Sharma, Prathiba Kurupati, Andrew Kwok, Angela Lee, Aline Linder, Teresa Lockett, Lorne Lonie, Maria Lopopolo, Martyna Lukoseviciute, Jian Luo, Spyridoula Marinou, Brian Marsden, Jose Martinez, Philippa C. Matthews, Michalina Mazurczyk, Simon McGowan, Stuart McKechnie, Adam Mead, Alexander J. Mentzer, Yuxin Mi, Claudia Monaco, Ruddy Montadon, Giorgio Napolitani, Isar Nassiri, Alex Novak, Darragh P. O'Brien, Daniel O'Connor, Denise O'Donnell, Graham Ogg, Lauren Overend, Inhye Park, Ian Pavord, Yanchun Peng, Frank Penkava, Mariana Pereira Pinho, Elena Perez, Andrew J. Pollard, Fiona Powrie, Bethan Psaila, T. Phuong Quan, Emmanouela Repapi, Santiago Revale, Laura Silva-Reyes, Jean-Baptiste Richard, Charlotte Rich-Griffin, Thomas Ritter, Christine S. Rollier, Matthew Rowland, Fabian Ruehle, Mariolina Salio, Stephen Nicholas Sansom, Raphael Sanches Peres, Alberto Santos Delgado, Tatjana Sauka-Spengler, Ron Schwessinger, Giuseppe Scozzafava, Gavin Screaton, Anna Seigal, Malcolm G. Semple, Martin Sergeant, Christina Simoglou Karali, David Sims, Donal Skelly, Hubert Slawinski, Alberto Sobrinodiaz, Nikolaos Sousos, Lizzie Stafford, Lisa Stockdale, Marie Strickland, Otto Sumray, Bo Sun, Chelsea Taylor, Stephen Taylor, Adan Taylor, Supat Thongjuea, Hannah Thraves, John A. Todd, Adriana Tomic, Orion Tong, Amy Trebes, Dominik Trzupek, Felicia Anna Tucci, Lance Turtle, Irina Udalova, Holm Uhlig, Erinke van Grinsven, Iolanda Vendrell, Marije Verheul, Alexandru Voda, Guanlin Wang, Lihui Wang, Dapeng Wang, Peter Watkinson, Robert Watson, Michael Weinberger, Justin Whalley, Lorna Witty, Katherine Wray, Luzheng Xue, Hing Yuen Yeung, Zixi Yin, Rebecca K. Young, Jonathan Youngs, Ping Zhang, Yasemin-Xiomara Zurke
Publikováno v:
Cell
2022, ' A blood atlas of COVID-19 defines hallmarks of disease severity and specificity ', Cell, vol. 185, no. 5, pp. 916-938.e58 . https://doi.org/10.1016/j.cell.2022.01.012
2022, ' A blood atlas of COVID-19 defines hallmarks of disease severity and specificity ', Cell, vol. 185, no. 5, pp. 916-938.e58 . https://doi.org/10.1016/j.cell.2022.01.012
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87a80bc978f9ac1dbe81c48b52553b3
https://pubmed.ncbi.nlm.nih.gov/35216673
https://pubmed.ncbi.nlm.nih.gov/35216673
Autor:
Boakye Serebour T; The Botnar Institute for Musculoskeletal Science, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Cribbs AP; The Botnar Institute for Musculoskeletal Science, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Baldwin MJ; The Botnar Institute for Musculoskeletal Science, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Masimirembwa C; The African Institute of Biomedical Science and Technology, Harare, Zimbabwe., Chikwambi Z; The African Institute of Biomedical Science and Technology, Harare, Zimbabwe., Kerasidou A; The Ethox Centre and the Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Snelling SJB; The Botnar Institute for Musculoskeletal Science, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. sarah.snelling@ndorms.ox.ac.uk.
Publikováno v:
European journal of human genetics : EJHG [Eur J Hum Genet] 2024 Oct; Vol. 32 (10), pp. 1206-1213. Date of Electronic Publication: 2024 Apr 02.
Autor:
Pessentheiner AR; Department of Medicine, UCSD, La Jolla, United States of America., Spann NJ; Department of Cellular and Molecular Medicine, UCSD, La Jolla, United States of America., Autran CA; Department of Pediatrics, UCSD, La Jolla, United States of America., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, United States of America., Grunddal KV; Department of Medicine, UCSD, La Jolla, United States of America., Coker JK; Department of Medicine, UCSD, La Jolla, United States of America., Painter CD; Department of Medicine, UCSD, La Jolla, United States of America., Ramms B; Department of Medicine, UCSD, La Jolla, United States of America., Chiang AW; Department of Pediatrics, UCSD, La Jolla, United States of America., Wang CY; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology an, National Institute of Health Research Oxford Biomedical Research Unit, Oxford, United Kingdom., Hsiao J; Department of Medicine, UCSD, La Jolla, United States of America., Wang Y; Department of Medicine, UCSD, La Jolla, United States of America., Quach A; Department of Medicine, UCSD, La Jolla, United States of America., Booshehri LM; Department of Pediatrics, UCSD, La Jolla, United States of America., Hammond A; Department of Pediatrics, UCSD, La Jolla, United States of America., Tognaccini C; Department of Medicine, UCSD, La Jolla, United States of America., Latasiewicz J; Department of Pediatrics, UCSD, La Jolla, United States of America., Willemsen L; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterda, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Zengler K; Department of Bioengineering, UCSD, La Jolla, United States of America., de Winther MP; Department of Medical Biochemistry, Experimental Vascular Biology, Amsterda, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Hoffman HM; Department of Medicine, UCSD, La Jolla, United States of America., Philpott M; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology an, National Institute of Health Research Oxford Biomedical Research Unit, Oxford, United Kingdom., Cribbs AP; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology an, National Institute of Health Research Oxford Biomedical Research Unit, Oxford, United Kingdom., Oppermann U; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology an, National Institute of Health Research Oxford Biomedical Research Unit, Oxford, United Kingdom., Lewis NE; Gene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, United States of America., Witztum JL; Department of Medicine, UCSD, La Jolla, United States of America., Yu R; Gene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, United States of America., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, United States of America., Downes M; Gene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, United States of America., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, United States of America., Glass CK; Department of Medicine, UCSD, La Jolla, United States of America., Bode L; Department of Pediatrics, UCSD, La Jolla, United States of America., Gordts PL; Department of Medicine, UCSD, La Jolla, United States of America.
Publikováno v:
JCI insight [JCI Insight] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.
Autor:
Xiong D; Department of Computational Biology, Cornell University, Ithaca, 14853, USA. dx38@cornell.edu.; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, 14853, USA. dx38@cornell.edu., U K; Department of Computational Biology, Cornell University, Ithaca, 14853, USA., Sun J; Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK. jianfeng.sun@ndorms.ox.ac.uk., Cribbs AP; Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK.
Publikováno v:
Interdisciplinary sciences, computational life sciences [Interdiscip Sci] 2024 Dec; Vol. 16 (4), pp. 802-813. Date of Electronic Publication: 2024 Aug 19.
Autor:
De Jonghe J; Francis Crick Institute, London, UK., Opzoomer JW; Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.; Relation Therapeutics, London, UK., Vilas-Zornoza A; Relation Therapeutics, London, UK., Crane P; Caeruleus Genomics, Oxford, UK., Nilges BS; OMAPiX GmbH, Langenfeld, Germany., Vicari M; Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden., Lee H; spatialist AB, Stockholm, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Lara-Astiaso D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Hematology, University of Cambridge, Cambridge, UK., Gross T; Relation Therapeutics, London, UK., Morf J; Skyhawk Therapeutics, Basel, Switzerland., Schneider K; Roche, Basel, Switzerland., Cudini J; Relation Therapeutics, London, UK., Ramos-Mucci L; Relation Therapeutics, London, UK., Mooijman D; Single Cell Discoveries, Utrecht, the Netherlands., Tiklová K; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Salas SM; spatialist AB, Stockholm, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Langseth CM; spatialist AB, Stockholm, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Kashikar ND; OMAPiX GmbH, Langenfeld, Germany., Roberts CES; Relation Therapeutics, London, UK.; ARK Investment Management, St. Petersburg, FL, USA., Lundeberg J; Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden., Nilsson M; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Shalek AK; Relation Therapeutics, London, UK.; Institute for Medical Engineering and Science, Department of Chemistry and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Cribbs AP; Caeruleus Genomics, Oxford, UK.; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, National Institute of Health Research Oxford Biomedical Research Unit (BRU), University of Oxford, Oxford, UK.; Oxford Centre for Translational Myeloma Research University of Oxford, Oxford, UK., Taylor-King JP; Relation Therapeutics, London, UK. jake@relationrx.com.
Publikováno v:
Nature biotechnology [Nat Biotechnol] 2024 Jul; Vol. 42 (7), pp. 1017-1023.
Autor:
Van Oekelen O; Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Amatangelo M; Translational Medicine, Bristol Myers Squibb, Summit, NJ, USA., Guo M; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, UK., Upadhyaya B; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cribbs AP; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Kelly G; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Patel M; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Flynt E; Translational Medicine, Bristol Myers Squibb, Summit, NJ, USA., Lagana A; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gooding S; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Merad M; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jagganath S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pierceall WE; Translational Medicine, Bristol Myers Squibb, Summit, NJ, USA., Oppermann U; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, UK; Oxford Translational Myeloma Centre (OTMC), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Thakurta A; Translational Medicine, Bristol Myers Squibb, Summit, NJ, USA; Oxford Translational Myeloma Centre (OTMC), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Parekh S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: samir.parekh@mssm.edu.
Publikováno v:
Cell reports. Medicine [Cell Rep Med] 2024 Jun 18; Vol. 5 (6), pp. 101584. Date of Electronic Publication: 2024 May 21.
Autor:
Mimpen JY; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Ramos-Mucci L; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Paul C; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Kurjan A; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Hulley PA; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Ikwuanusi CT, Cohen CJ; Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland., Gwilym SE; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Baldwin MJ; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Cribbs AP; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Snelling SJB; The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 May 31; Vol. 38 (10), pp. e23629.
Autor:
Ayagama T; Department of Pharmacology, University of Oxford, Oxford, UK., Charles PD; Target Discovery Institute, University of Oxford, Oxford, UK., Bose SJ; Department of Pharmacology, University of Oxford, Oxford, UK., Boland B; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Priestman DA; Department of Pharmacology, University of Oxford, Oxford, UK., Aston D; Department of Anaesthesia and Critical Care, Royal Papworth Hospital NHS Foundation Trust, Papworth Road, Cambridge CB2 0AY, UK., Berridge G; Target Discovery Institute, University of Oxford, Oxford, UK., Fischer R; Target Discovery Institute, University of Oxford, Oxford, UK., Cribbs AP; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Headington OX3 7LD, UK., Song Q; Department of Pharmacology, University of Oxford, Oxford, UK., Mirams GR; Centre for Mathematical Medicine & Biology, Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Amponsah K; Centre for Mathematical Medicine & Biology, Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Heather L; Department of Physiology, Anatomy and Genetics, , University of Oxford, South Park Road, Oxford OX1 3PT, UK., Galione A; Department of Pharmacology, University of Oxford, Oxford, UK., Herring N; Department of Physiology, Anatomy and Genetics, , University of Oxford, South Park Road, Oxford OX1 3PT, UK., Kramer H; Mass spectrometry Facility, The MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Capel RA; Department of Pharmacology, University of Oxford, Oxford, UK., Platt FM; Department of Pharmacology, University of Oxford, Oxford, UK., Schotten U; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands., Verheule S; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands., Burton RAB; Department of Pharmacology, University of Oxford, Oxford, UK.; University of Liverpool, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, Liverpool, UK.
Publikováno v:
IScience [iScience] 2024 Mar 28; Vol. 27 (6), pp. 109609. Date of Electronic Publication: 2024 Mar 28 (Print Publication: 2024).