Polymeric Micellar Nanoparticles Enable Image-guided Drug Delivery in Solid Tumors.

Autor: Uddin J, Oltman CG, Lo JH, Gupta MK, Werfel TA, Mohyuddin M, Nazmin F, Rahman S, Crews BC, Kingsley PJ, Marnett LJ, Duvall CL, Cook RS

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 10. Date of Electronic Publication: 2024 Jun 10.

Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase-2 in Cells and Animals.

Autor: Uddin MJ; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Lo JH; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States., Oltman CG; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Crews BC; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Huda T; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Liu J; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Neuroscience, Columbia University, New York City, New York 10027, United States., Kingsley PJ; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Lin S; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Milad M; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Aleem AM; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Asaduzzaman A; Department of Electrical Engineering and Computer Science, Wichita State University, Wichita, Kansas 67260, United States., McIntyre JO; Departments of Radiology and Radiological Sciences, and Pharmacology, Vanderbilt Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232, United States., Marnett LJ; Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2022 Jul 15; Vol. 17 (7), pp. 1714-1722. Date of Electronic Publication: 2022 Jul 05.

Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors.

Autor: Uddin MJ; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Xu S; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Crews BC; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Aleem AM; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Ghebreselasie K; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Banerjee S; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.; Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439, United States., Marnett LJ; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Feb 14; Vol. 11 (10), pp. 1881-1885. Date of Electronic Publication: 2020 Feb 14 (Print Publication: 2020).

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer.

Autor: Uddin MJ; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Wilson AJ; Department of Obstetrics & Gynecology, Women's Reproductive Health Research Center, and Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States., Crews BC; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Malerba P; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Department of Pharmacy & Pharmaceutical Sciences, University of Bari 'A. Moro', Via Orabona 4, 70125 Bari, Italy., Uddin MI; Department of Obstetrics & Gynecology, Women's Reproductive Health Research Center, and Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States., Kingsley PJ; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Ghebreselasie K; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Daniel CK; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Nickels ML; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Tantawy MN; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Jashim E; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Martin Luther King Jr. Academic Magnet School of Health Sciences and Engineering, 613 17th Avenue North, Nashville, Tennessee 37203, United States., Manning HC; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Khabele D; Department of Obstetrics & Gynecology, Women's Reproductive Health Research Center, and Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.; Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, Kansas 66160, United States., Marnett LJ; A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, and Department of Radiology and Radiological Sciences, Vanderbilt Institute of Imaging Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Publikováno v: ACS omega [ACS Omega] 2019 May 31; Vol. 4 (5), pp. 9251-9261. Date of Electronic Publication: 2019 May 24.

Prostaglandin E 2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y 6 .

Autor: Brüser A; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany. antje.brueser@medizin.uni-leipzig.de., Zimmermann A; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany., Crews BC; Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232-0146, USA., Sliwoski G; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 37232-8725, USA., Meiler J; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN, 37232-8725, USA., König GM; Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Kostenis E; Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany., Lede V; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany., Marnett LJ; Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232-0146, USA., Schöneberg T; Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany. schoberg@medizin.uni-leipzig.de.

Publikováno v: Scientific reports [Sci Rep] 2017 May 24; Vol. 7 (1), pp. 2380. Date of Electronic Publication: 2017 May 24.