Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission.

Autor: Pala ZR; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Alves E Silva TL; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Minai M; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Crews B; Microscopy Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA., Patino-Martinez E; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Carmona-Rivera C; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Valenzuela Leon PC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Martin-Martin I; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.; Laboratory of Medical Entomology, National Center for Microbiology, Instituto de Salud Carlos III, 28220, Majadahonda, Madrid, Spain., Flores-Garcia Y; Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Cachau RE; Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Muslinkina L; Structural Biology Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Gittis AG; Structural Biology Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Srivastava N; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Garboczi DN; Structural Biology Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Alves DA; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Kaplan MJ; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Fischer E; Microscopy Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA., Calvo E; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA., Vega-Rodriguez J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA. joel.vega-rodriguez@nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 18; Vol. 15 (1), pp. 8194. Date of Electronic Publication: 2024 Sep 18.

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A Survey of Two-Component Systems in Coxiella burnetii Reveals Redundant Regulatory Schemes and a Requirement for an Atypical PhoBR System in Mammalian Cell Infection.

Autor: Wachter S; Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.; Vaccine and Infectious Disease Organization, Saskatoon, Saskatchewan, Canada., Larson CL; Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Virtaneva K; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA., Kanakabandi K; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA., Darwitz B; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA., Crews B; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA., Storrud K; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA., Heinzen RA; Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA., Beare PA; Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.; Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA.

Publikováno v: Journal of bacteriology [J Bacteriol] 2023 Mar 21; Vol. 205 (3), pp. e0041622. Date of Electronic Publication: 2023 Feb 27.

1H-NMR Analysis of Amino Acid Metabolism in Cerebrospinal Fluid of Dogs with Neurological Distemper.

Autor: Gülersoy, Erdem¹ (AUTHOR) egulersoy@harran.edu.tr, Balikçi, Canberk¹ (AUTHOR), Günal, Ismail¹ (AUTHOR), Şahan, Adem¹ (AUTHOR), Kismet, Esma¹ (AUTHOR), Akdağ, Fatma¹ (AUTHOR), Ok, Mahmut² (AUTHOR)

Publikováno v: Macedonian Veterinary Review. Oct2024, Vol. 47 Issue 2, p131-140. 10p.

Identifying mechanism-of-action targets for drugs and probes

Autor: Roth, B. L., Irwin, J. J., Setola, V., Lounkine, E., Marnett, L., Crews, B. A., Shoichet, B. K., Hert, J., Gregori-Puigjane, E.

Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to “de-orph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::478baaecb1e6373092407886edb1303c