Výsledky vyhledávání - "Crettaz, J. (Julien)"

Production of recombinant woodchuck IFNalpha and development of monoclonal antibodies

Autor: Berraondo, P. (Pedro), Crettaz, J. (Julien), Ochoa, L. (Laura), Vales, A. (África), Ruiz, J. (Juan), Prieto, J. (Jesús), Martinez-Anso, E. (Eduardo), González-Aseguinolaza, G. (Gloria)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Interferon alpha (IFNalpha) is the first line treatment for chronic hepatitis B and C. In order to test new IFNalpha delivery systems and investigate the function of this cytokine in the woodchuck model, the best animal model of chronic hepatitis B,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3077c5f89fdf1f8af3fe954f1262e889
https://hdl.handle.net/10171/20304

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Semliki forest virus expressing interleukin-12 induces antiviral and antitumoral responses in woodchucks with chronic viral hepatitis and hepatocellular carcinoma

Autor: Rodriguez-Madoz, J.R. (Juan Roberto), Liu, K.H. (Katherine H.), Quetglas, J.I. (José Ignacio), Ruiz-Guillen, M. (Marta), Otano, I. (Itziar), Crettaz, J. (Julien), Butler, S.D. (Scott D.), Bellezza, C.A. (Christine A.), Dykes, N.L. (Nathan L.), Tennant, B.C. (Bud C.), Prieto, J. (Jesús), González-Aseguinolaza, G. (Gloria), Smerdou, C. (Cristian), Menne, S. (Stephan)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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A vector based on Semliki Forest virus (SFV) expressing high levels of interleukin-12 (SFV-enhIL-12) has previously demonstrated potent antitumoral efficacy in small rodents with hepatocellular carcinoma (HCC) induced by transplantation of tumor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ddf274a50330734ac72677729f911643
https://hdl.handle.net/10171/23246

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IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes

Autor: Berraondo, P. (Pedro), Ochoa, L. (Laura), Crettaz, J. (Julien), Rotellar, F. (Fernando), Vales, A. (África), Martinez-Anso, E. (Eduardo), Zaratiegui, M. (Mikel), Ruiz, J. (Juan), González-Aseguinolaza, G. (Gloria), Prieto, J. (Jesús)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname

Gene delivery of IFN-alpha to the liver may represent an interesting strategy to maximize its antiviral efficacy and reduce side effects. We used a recombinant adeno-associated virus (AAV) encoding woodchuck IFN-alpha (AAV-IFN) to treat animals with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6892686032ebee40000bb7d55ddcf40f
https://hdl.handle.net/10171/20332

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