Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer.

Autor: Fernandez-Mateos J; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; St. Anna Children's Cancer Research Institute, Vienna, Austria., Trahearn N; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Webb K; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Sakr C; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lampis A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Stuttle C; The Royal Marsden NHS Foundation Trust, London, UK.; Oncogenetics Team, The Institute of Cancer Research, London, UK., Corbishley CM; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.; St. George's Hospital Healthcare NHS Trust, London, UK., Stavrinides V; Division of Surgery and Interventional Science, UCL, London, UK., Zapata L; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Gallagher L; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., James C; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Ramazzotti D; University of Milano Bicocca, Milan, Italy., Gao A; Bob Champion Cancer Unit, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; Oncogenetics Team, The Institute of Cancer Research, London, UK., Acar A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Biological Sciences, Middle East Technical University, Ankara, Turkey., Truelove L; Bob Champion Cancer Unit, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Proszek P; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., Murray J; The Royal Marsden NHS Foundation Trust, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Reid A; The Royal Marsden NHS Foundation Trust, London, UK., Wilkins A; The Royal Marsden NHS Foundation Trust, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Hubank M; Molecular Pathology Section, The Institute of Cancer Research, London, UK.; Clinical Genomics, The Royal Marsden NHS Foundation, London, UK., Eeles R; The Royal Marsden NHS Foundation Trust, London, UK.; Oncogenetics Team, The Institute of Cancer Research, London, UK., Dearnaley D; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK. david.dearnaley@icr.ac.uk.; Academic Urology Unit, The Royal Marsden NHS Foundation Trust, London, UK. david.dearnaley@icr.ac.uk., Sottoriva A; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.; Computational Biology Research Centre, Human Technopole, Milan, Italy. andrea.sottoriva@fht.org.

Publikováno v: Nature cancer [Nat Cancer] 2024 Sep; Vol. 5 (9), pp. 1334-1351. Date of Electronic Publication: 2024 Jul 12.

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.

Autor: Saldana-Guerrero IM; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK.; Sheffield Institute for Nucleic Acids (SInFoNiA), School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Montano-Gutierrez LF; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Boswell K; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Hafemeister C; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Poon E; Division of Clinical Studies, The Institute of Cancer Research (ICR) & Royal Marsden NHS Trust, London, UK., Shaw LE; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Stavish D; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Lea RA; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Wernig-Zorc S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bozsaky E; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Fetahu IS; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Medical University of Vienna, Department of Neurology, Division of Neuropathology and Neurochemistry, Vienna, Austria., Zoescher P; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Pötschger U; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bernkopf M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; Labdia Labordiagnostik GmbH, Vienna, Austria., Wenninger-Weinzierl A; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Sturtzel C; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Souilhol C; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK.; Biomolecular Sciences Research Centre, Department of Biosciences and Chemistry, Sheffield Hallam University, Sheffield, UK., Tarelli S; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Shoeb MR; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bozatzi P; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Rados M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Guarini M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Buri MC; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Weninger W; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Putz EM; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Huang M; Children's Hospital Los Angeles, Cancer and Blood Disease Institutes, and The Saban Research Institute, Los Angeles, CA, USA.; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ladenstein R; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Andrews PW; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK., Barbaric I; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.; Neuroscience Institute, The University of Sheffield, Sheffield, UK., Cresswell GD; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Bryant HE; Sheffield Institute for Nucleic Acids (SInFoNiA), School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Distel M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Chesler L; Division of Clinical Studies, The Institute of Cancer Research (ICR) & Royal Marsden NHS Trust, London, UK., Taschner-Mandl S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Farlik M; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Tsakiridis A; Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK. a.tsakiridis@sheffield.ac.uk.; Neuroscience Institute, The University of Sheffield, Sheffield, UK. a.tsakiridis@sheffield.ac.uk., Halbritter F; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. florian.halbritter@ccri.at.

Publikováno v: Nature communications [Nat Commun] 2024 May 03; Vol. 15 (1), pp. 3745. Date of Electronic Publication: 2024 May 03.

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer.

Autor: Lakatos E; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Gunasri V; UCL Cancer Institute, University College London, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Househam J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Heide T; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Trahearn N; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Swinyard O; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Cisneros L; Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences Arizona State University, Tempe, USA., Lynn C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Mossner M; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kimberley C; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Spiteri I; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Llibre-Palomar G; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Mitchison M; Histopathology Department, University College London Hospitals NHS Foundation Trust, London, UK., Maley CC; Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences Arizona State University, Tempe, USA., Jansen M; UCL Cancer Institute, University College London, London, UK., Rodriguez-Justo M; UCL Cancer Institute, University College London, London, UK., Bridgewater J; UCL Cancer Institute, University College London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 14. Date of Electronic Publication: 2024 Feb 14.

The co-evolution of the genome and epigenome in colorectal cancer.

Autor: Heide T; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Househam J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Cresswell GD; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Spiteri I; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Lynn C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Mossner M; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kimberley C; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Fernandez-Mateos J; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Chen B; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., James C; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Barozzi I; Department of Surgery and Cancer, Imperial College London, London, UK.; Centre for Cancer Research, Medical University of Vienna, Vienna, Austria., Chkhaidze K; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Nichol D; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Gunasri V; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Berner A; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Schmidt M; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Lakatos E; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Costa H; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Mitchinson M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Piazza R; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Jansen M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Caravagna G; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Department of Mathematics and Geosciences, University of Triest, Triest, Italy., Ramazzotti D; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Shibata D; Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA., Bridgewater J; UCL Cancer Institute, University College London, London, UK., Rodriguez-Justo M; Department of Pathology, UCL Cancer Institute, University College London, London, UK., Magnani L; Department of Surgery and Cancer, Imperial College London, London, UK., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk.; Evolution and Cancer Lab, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK. trevor.graham@icr.ac.uk., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. andrea.sottoriva@fht.org.; Computational Biology Research Centre, Human Technopole, Milan, Italy. andrea.sottoriva@fht.org.

Publikováno v: Nature [Nature] 2022 Nov; Vol. 611 (7937), pp. 733-743. Date of Electronic Publication: 2022 Oct 26.

Pervasive chromosomal instability and karyotype order in tumour evolution.

Autor: Watkins TBK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Lim EL; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Petkovic M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Elizalde S; Department of Mathematics, Dartmouth College, Hanover, NH, USA., Birkbak NJ; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.; Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark., Wilson GA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Grönroos E; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Rowan A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Dewhurst SM; Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA., Demeulemeester J; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.; Department of Human Genetics, University of Leuven, Leuven, Belgium., Dentro SC; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.; Oxford Big Data Institute, University of Oxford, Oxford, UK.; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Horswell S; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK., Au L; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Haase K; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK., Escudero M; Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK., Rosenthal R; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Bakir MA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Xu H; Stanford Cancer Institute, Stanford, CA, USA., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Lu WT; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Mourikis TP; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Dietzen M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK., Spain L; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Cresswell GD; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK., Biswas D; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Lamy P; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Nordentoft I; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Harbst K; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.; Lund University Cancer Centre, Lund University, Lund, Sweden., Castro-Giner F; Department of Biomedicine, Cancer Metastasis Laboratory, University of Basel and University Hospital Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland., Yates LR; Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Caramia F; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia., Jaulin F; INSERM U1279, Gustave Roussy, Villejuif, France., Vicier C; Department of Medical Oncology, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Tomlinson IPM; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK., Brastianos PK; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Cho RJ; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Bastian BC; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Dyrskjøt L; Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark., Jönsson GB; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.; Lund University Cancer Centre, Lund University, Lund, Sweden., Savas P; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Loi S; Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Campbell PJ; Wellcome Trust Sanger Institute, Hinxton, UK., Andre F; INSERM U981, PRISM Institute, Gustave Roussy, Villejuif, France.; Department of Medical Oncology, Gustave Roussy, Villejuif, France.; Medical School, Université Paris Saclay, Kremlin Bicetre, France., Luscombe NM; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK.; UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, London, UK.; Okinawa Institute of Science & Technology, Okinawa, Japan., Steeghs N; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Tjan-Heijnen VCG; Department of Medical Oncology, School of GROW, Maastricht University Medical Center, Maastricht, The Netherlands., Szallasi Z; Danish Cancer Society Research Center, Copenhagen, Denmark.; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.; 2nd Department of Pathology, SE-NAP Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary., Turajlic S; Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Medical Oncology, University College London Hospitals, London, UK., Van Loo P; Cancer Genomics Laboratory, The Francis Crick Institute, London, UK., Bakhoum SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schwarz RF; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany. roland.schwarz@mdc-berlin.de.; German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany. roland.schwarz@mdc-berlin.de.; German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.schwarz@mdc-berlin.de., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK. nicholas.mcgranahan.10@ucl.ac.uk., Swanton C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.; Department of Medical Oncology, University College London Hospitals, London, UK. charles.swanton@crick.ac.uk.

Publikováno v: Nature [Nature] 2020 Nov; Vol. 587 (7832), pp. 126-132. Date of Electronic Publication: 2020 Sep 02.