Zobrazeno 1 - 10
of 2 123
pro vyhledávání: '"Crean, P."'
In $4$-dimensional pure compact $U(1)$ lattice gauge theory, we analyse topological aspects of the dynamics of monopoles across the deconfinement phase transition. We do this using tools from Topological Data Analysis (TDA). We demonstrate that obser
Externí odkaz:
http://arxiv.org/abs/2403.07739
Autor:
Angela Jane Crean, Alistair McNair Senior, Therese Freire, Thomas Daniel Clark, Flora Mackay, Gracie Austin, Tamara Jayne Pulpitel, Marcelo Aguiar Nobrega, Romain Barrès, Stephen James Simpson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-co
Externí odkaz:
https://doaj.org/article/728550fe9d6d450a99df955ed72345e6
Autor:
Kathryn M. Farris, Alistair M. Senior, Débora R. Sobreira, Robert M. Mitchell, Zachary T. Weber, Lars R. Ingerslev, Romain Barrès, Stephen J. Simpson, Angela J. Crean, Marcelo A. Nobrega
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronutrient composition. While the impact of caloric intake on gene expression and physiological phenomena in var
Externí odkaz:
https://doaj.org/article/7dbebc4349a940b19cdb5cc883a0451e
Publikováno v:
QRB Discovery, Vol 5 (2024)
Protein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation. WPD-loop
Externí odkaz:
https://doaj.org/article/32a8f2bafca546caae7c24425fd85836
Autor:
Jorrit Tjeertes, Carlos A. Bacino, Terry Jo Bichell, Lynne M. Bird, Mariana Bustamante, Rebecca Crean, Shafali Jeste, Robert W. Komorowski, Michelle L. Krishnan, Meghan T. Miller, David Nobbs, Cesar Ochoa-Lubinoff, Kimberly A. Parkerson, Alexander Rotenberg, Anjali Sadhwani, Mark D. Shen, Lisa Squassante, Wen-Hann Tan, Brenda Vincenzi, Anne C. Wheeler, Joerg F. Hipp, Elizabeth Berry-Kravis
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by the absence of a functional UBE3A gene, which causes developmental, behavioral, and medical challenges. While currently untreatable, comprehensive data
Externí odkaz:
https://doaj.org/article/ef450fe783de498baf723d4e7e4e74fb
Autor:
Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers has
Externí odkaz:
https://doaj.org/article/2717acaed3114fb5964d7b172163769d
Autor:
A. J. Crean, S. Afrin, H. Niranjan, T. J. Pulpitel, G. Ahmad, A. M. Senior, T. Freire, F. Mackay, M. A. Nobrega, R. Barrès, S. J. Simpson, T. Pini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework
Externí odkaz:
https://doaj.org/article/358f3cbd13d74c4d983a34343d0bce52
Autor:
David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2852 (2024)
Hypercapnia occurs when the partial pressure of carbon dioxide (CO2) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and is transcriptionally linked to suppression of immune and inflammatory signalling through po
Externí odkaz:
https://doaj.org/article/a538e415c47d4983ab84f11c5a7733b9
Autor:
Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciarán Kennedy, Aline F. Miller, Alberto Saiani, Jacek K. Wychowaniec, Dermot F. Brougham, John Crean
Publikováno v:
Bioactive Materials, Vol 21, Iss , Pp 142-156 (2023)
Human induced pluripotent stem cell (hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised medicine. However, there remains a necessity to refine the biophysical and biochemical parameters
Externí odkaz:
https://doaj.org/article/e2d13a4d716e47b4b691e887cb4c6098
Autor:
Joseph Roche, Gillian L. Barber, Laura Bell, Autumn Brown, Sadhbh Crean, Orlaith Darling, Amy Fahy, Sylvia Healy, Theresa Heffernan, Mairéad Hurley, Anne Kearns, Angeliki Lima, Louise McAteer, Amelia McConville, Anna Mwakitalu, Eleanor Quasebarth Neil, Fiona Smyth, Aoife Taylor, Shaun Ussher, Anna Wedderburn, Caitlin White, Katerina Zouboulakis
Publikováno v:
Frontiers in Environmental Science, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/b892061bdb5b4cb884c6ab23e6df7c39