Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Autor: Hobbs, BD, de Jong, K, Lamontagne, M, Bossé, Y, Shrine, N, Artigas, MS, Wain, LV, Hall, IP, Jackson, VE, Wyss, AB, London, SJ, North, KE, Franceschini, N, Strachan, DP, Beaty, TH, Hokanson, JE, Crapo, JD, Castaldi, PJ, Chase, RP, Bartz, TM, Heckbert, SR, Psaty, BM, Gharib, SA, Zanen, P, Lammers, JW, Oudkerk, M, Groen, HJ, Locantore, N, Tal-Singer, R, Rennard, SI, Vestbo, J, Timens, W, Paré, PD, Latourelle, JC, Dupuis, J, O'Connor, GT, Wilk, JB, Kim, WJ, Lee, MK, Oh, Y-M, Vonk, JM, de Koning, HJ, Leng, S, Belinsky, SA, Tesfaigzi, Y, Manichaikul, A, Wang, X-Q, Rich, SS, Barr, RG, Sparrow, D, Litonjua, AA, Bakke, P, Gulsvik, A, Lahousse, L, Brusselle, GG, Stricker, BH, Uitterlinden, AG, Ampleford, EJ, Bleecker, ER, Woodruff, PG, Meyers, DA, Qiao, D, Lomas, DA, Yim, J-J, Kim, DK, Hawrylkiewicz, I, Sliwinski, P, Hardin, M, Fingerlin, TE, Schwartz, DA, Postma, DS, MacNee, W, Tobin, MD, Silverman, EK, Boezen, HM, Cho, MH, COPDGene Investigators, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium

Publikováno v: Nature Genetics

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::834c3a21a0c01477de684e2e7b49ebc3
https://openaccess.sgul.ac.uk/id/eprint/108399/7/NG-LE43518R_main_paper.pdf

Clinical and radiologic disease in smokers with normal spirometry

Autor: Regan, EA, Lynch, DA, Curran-Everett, D, Curtis, JL, Austin, JHM, Grenier, PA, Kauczor, HU, Bailey, WC, De Meo, DL, Casaburi, RH, Friedman, P, Van Beek, EJR, Hokanson, JE, Bowler, RP, Beaty, TH, Washko, GR, Han, MK, Kim, V, Kim, SS, Yagihashi, K, Washington, L, McEvoy, CE, Tanner, C, Mannino, DM, Make, BJ, Silverman, EK, Crapo, JD, Martinez, C, Pernicano, PG, Hanania, N, Alapat, P, Bandi, V, Atik, M, Boriek, A, Guntupalli, K, Guy, E, Parulekar, A, Nachiappan, A, Hersh, C, Jacobson, F, Barr, RG, Thomashow, B, D'Souza, B, Pearson, GDN, Rozenshtein, A, MacIntyre, N, McAdams, HP, Tashjian, J, Wise, R, Hansel, N, Brown, R, Horton, K, Putcha, N, Adami, A, Porszasz, J, Fischer, H, Budoff, M, Cannon, D, Rossiter, H, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Foreman, M, Westney, G, Berkowitz, E, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, R, Desai, P, Jacobs, M, Kelsen, S, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, G, Dransfield, M, Wells, JM, Bhatt, S, Nath, H, Ramsdell, J, Soler, X, Yen, A, Cornellas, A, Newell, J, Thompson, B, Kazerooni, E, Martinez, F, Billings, J, Allen, T

Publikováno v: Regan, EA; Lynch, DA; Curran-Everett, D; Curtis, JL; Austin, JHM; Grenier, PA; et al.(2015). Clinical and radiologic disease in smokers with normal spirometry. JAMA Internal Medicine, 175(9), 1539-1549. doi: 10.1001/jamainternmed.2015.2735. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1h82f9z8

Copyright 2015 American Medical Association. All rights reserved. IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2629b6ee5e60f54565ffe30027b3baaf
http://www.escholarship.org/uc/item/1h82f9z8

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

Autor: Dijkstra, Akkelies E., Smolonska, J, Van Den Berge, M, Wijmenga, C, Zanen, P, Luinge, MA, Platteel, M, Lammers, JW, Dahlback, M, Tosh, K, Hiemstra, PS, Sterk, PJ, Spira, A, Vestbo, J, Nordestgaard, BG, Benn, M, Nielsen, SF, Dahl, M, Verschuren, WM, Picavet, HSJ, Smit, HA, Owsijewitsch, M, Kauczor, HU, De Koning, HJ, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, Van Diemen, CC, Cho, MH, Silverman, EK, Crapo, JD, Beaty, TH, Lomas, DA, Bakke, Per, Gulsvik, Amund, Bosse, Y, Obeidat, MA, Loth, DW, Lahousse, L, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Stricker, BH, Brusselle, GG, Van Duijn, CM, Brouwer, U, Koppelman, GH, Vonk, JM, Nawijn, MC, Groen, HJM, Timens, W, Boezen, HM, Postma, DS, Alizadeh, BZ, De Boer, RA, Bruinenberg, M, Franke, L, Van Der Harst, P, Hillege, HL, Van Der Klauw, MM, Navis, G, Ormel, J, Rosmalen, J, Slaets, JP, Snieder, H, Stolk, RP, Wolffenbuttel, B

Publikováno v: PLoS ONE
Dijkstra, A E, Smolonska, J, van den Berge, M, Wijmenga, C, Zanen, P, Luinge, M A, Platteel, M, Lammers, J W, Dahlback, M, Tosh, K, Hiemstra, P S, Sterk, P J, Spira, A, Vestbo, J, Nordestgaard, B G, Benn, M, Nielsen, S F, Dahl, M, Verschuren, W M, Picavet, H S J, Smit, H A, Owsijewitsch, M, Kauczor, H U, de Koning, H J, Nizankowska-Mogilnicka, E, Mejza, F, Nastalek, P, van Diemen, C C, Cho, M H, Silverman, E K, Crapo, J D, Beaty, T H, Lomas, D A, Bakke, P, Gulsvik, A, Bosse, Y, Obeidat, M A, Loth, D W, Lahousse, L, Rivadeneira, F, Uitterlinden, A G, Hofman, A, Stricker, B H, Brusselle, G G, van Duijn, C, Brouwer, U, Koppelman, G H, Vonk, J M, Nawijn, M C, Groen, H J M, Timens, W, Boezen, H M, Postma, D S & LifeLines Cohort, S 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', P L o S One, vol. 9, no. 4, e91621, pp. 13 . https://doi.org/10.1371/journal.pone.0091621
LifeLines Cohort Study 2014, ' Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study ', PLoS ONE, vol. 9, no. 4, e91621 . https://doi.org/10.1371/journal.pone.0091621
e91621
PLoS ONE, 9(4). Public Library of Science
PLoS One (print), 9(4). Public Library of Science
PLoS ONE, Vol 9, Iss 4, p e91621 (2014)
PLoS ONE, 9(4)
PLOS ONE
PLoS ONE, 9(4):e91621. PUBLIC LIBRARY SCIENCE
PLoS ONE; Vol 9

Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74529ee25996a8245709890a3470ca4
https://pubmed.ncbi.nlm.nih.gov/26024482

Quantitative CT of the Lungs and Airways in Healthy Non-smoking Adults

Autor: Zach, JA, Newell, JD, Schroeder, J, Murphy, JR, Curran-Everett, D, Hoffman, EA, Westgate, PM, Han, MK, Silverman, EK, Crapo, JD, Lynch, DA

The purposes of this study were to evaluate the reference range of quantitative computed tomography (QCT) measures of lung attenuation and airway parameter measurements in healthy nonsmoking adults and to identify sources of variation in those measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc6070cae4ea8e4b8d744765d8358462
https://europepmc.org/articles/PMC3703944/

Oxidative stress as an initiator of cytokine release and cell damage

Autor: Crapo Jd

Publikováno v: The European respiratory journal. Supplement. 44

This article characterised the role of oxidative stress in mediating pathological reactions in the lung and the unique antioxidant defences that the lung possesses. The impact of redox balance in regulating inflammatory and immune reactions were disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14b82cf270549db2f3f4e6a6928036a
https://pubmed.ncbi.nlm.nih.gov/14582891