Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity.

Autor: Malik Y; School of Biosciences, University of Kent, Canterbury, United Kingdom., Kulaberoglu Y; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Anver S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Javidnia S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Borland G; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Rivera R; School of Biosciences, University of Kent, Canterbury, United Kingdom., Cranwell S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Medelbekova D; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Svermova T; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Thomson J; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Broughton S; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom., von der Haar T; School of Biosciences, University of Kent, Canterbury, United Kingdom., Selman C; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tullet JMA; School of Biosciences, University of Kent, Canterbury, United Kingdom., Alic N; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom.

Publikováno v: PLoS biology [PLoS Biol] 2024 Oct 22; Vol. 22 (10), pp. e3002853. Date of Electronic Publication: 2024 Oct 22 (Print Publication: 2024).

Mendelian randomization analyses implicate biogenesis of translation machinery in human aging.

Autor: Javidnia S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Cranwell S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Mueller SH; Institute of Health Informatics, University College London, London NW1 2DA, United Kingdom., Selman C; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Tullet JMA; School of Biosciences, University of Kent, Canterbury CT2 7NZ, United Kingdom., Kuchenbaecker K; UCL Genetics Institute, Research Department of Genetics Evolution and Environment, University College London, London WC1E 6BT, United Kingdom.; Division of Psychiatry, University College London, London W1T 7NF, United Kingdom., Alic N; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London WC1E 6BT, United Kingdom.

Publikováno v: Genome research [Genome Res] 2022 Feb; Vol. 32 (2), pp. 258-265. Date of Electronic Publication: 2022 Jan 25.

Globally important islands where eradicating invasive mammals will benefit highly threatened vertebrates.

Autor: Holmes ND; Island Conservation, Delaware Ave, Santa Cruz California, United States of America., Spatz DR; Island Conservation, Delaware Ave, Santa Cruz California, United States of America.; Ecology and Evolutionary Biology Department, University of California Santa Cruz, Santa Cruz, California, United States of America., Oppel S; Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire, United Kigndom., Tershy B; Ecology and Evolutionary Biology Department, University of California Santa Cruz, Santa Cruz, California, United States of America., Croll DA; Ecology and Evolutionary Biology Department, University of California Santa Cruz, Santa Cruz, California, United States of America., Keitt B; Island Conservation, Delaware Ave, Santa Cruz California, United States of America.; American Bird Conservancy, The Plains, Virginia, United States of America., Genovesi P; Institute for Environmental Protection and Research ISPRA and Chair IUCN Invasive Species Specialist Group, Via V. Brancati, Rome, Italy., Burfield IJ; BirdLife International, Cambridge, United Kigndom., Will DJ; Island Conservation, Delaware Ave, Santa Cruz California, United States of America., Bond AL; Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire, United Kigndom.; Bird Group, Department of Life Sciences, The Natural History Museum, Tring, Hertfordshire, United Kigndom., Wegmann A; Island Conservation, Delaware Ave, Santa Cruz California, United States of America.; The Nature Conservancy, Nuuanu Ave, Honolulu, Hawai'i, United States of America., Aguirre-Muñoz A; Grupo de Ecología y Conservación de Islas, A.C. Av. Moctezuma, Zona Centro, Ensenada, B.C., Mexico., Raine AF; Kaua`i Endangered Seabird Recovery Project, Hanapepe, Kaua`i, Hawai'i, United States of America., Knapp CR; John G. Shedd Aquarium, IUCN Iguana Specialist Group, S Lake Shore Dr, Chicago, Illinois, United States of America., Hung CH; School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan., Wingate D; Bermuda Zoological Society, Hamilton, Bermuda., Hagen E; Island Conservation, Delaware Ave, Santa Cruz California, United States of America., Méndez-Sánchez F; Grupo de Ecología y Conservación de Islas, A.C. Av. Moctezuma, Zona Centro, Ensenada, B.C., Mexico., Rocamora G; Island Biodiversity & Conservation center, University of Seychelles, Anse Royale, Mahé, Seychelles., Yuan HW; School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan., Fric J; Nature Conservation Consultants Ltd, Gytheiou Chalandri, Greece., Millett J; Victoria, Mahé, Seychelles., Russell J; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Liske-Clark J; Division of Fish & Wildlife, Commonwealth of the Northern Marianas, Lower Base, Saipan Commonwealth of the Northern Mariana Islands., Vidal E; Institut Méditerranéen de Biodiversité et d'Ecologie marine et continentale, Aix Marseille Université, CNRS, IRD, Avignon Université, Centre IRD de Nouméa, Nouméa cedex, New-Caledonia., Jourdan H; Institut Méditerranéen de Biodiversité et d'Ecologie marine et continentale, Aix Marseille Université, CNRS, IRD, Avignon Université, Centre IRD de Nouméa, Nouméa cedex, New-Caledonia., Campbell K; Island Conservation, Delaware Ave, Santa Cruz California, United States of America., Springer K; Rinaldi Avenue, The Pines Beach, North Canterbury, New Zealand., Swinnerton K; The Island Endemics Foundation, Boqueron, Puerto Rico, United States of America., Gibbons-Decherong L; Palau Conservation Society, Palau Conservation Society, Bai Ra Maibrel, Koror, Palau., Langrand O; Critical Ecosystem Partnership Fund, Crystal Drive, Arlington, Virginia, United States of America., Brooke ML; Department of Zoology, University of Cambridge, Cambridge, United Kigndom., McMinn M; BIOGEOMED Group, University of the Balearic Islands, Cra, Valdemossa Balearic Islands, Spain., Bunbury N; Seychelles Islands Foundation, La Ciotat Building, Mont Fleuri, Victoria, Mahé, Seychelles.; Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Penryn, United Kigndom., Oliveira N; Sociedade Portuguesa para o Estudo das Aves, Avenida Columbano Bordalo Pinheiro, Lisboa, Portugal., Sposimo P; NEMO Srl, Piazza D'Azeglio, Florence, Italy., Geraldes P; Sociedade Portuguesa para o Estudo das Aves, Avenida Columbano Bordalo Pinheiro, Lisboa, Portugal., McClelland P; Kennington-Roslyn Bush Road, Invercargill, New Zealand., Hodum P; Oikonos Ecosystem Knowledge, Kailua, Hawai'i, United States of America., Ryan PG; FitzPatrick Institute of African Ornithology, University of Cape Town, Rondebosch, South Africa., Borroto-Páez R; Sociedad Cubana de Zoología, La Habana, Cuba., Pierce R; Stoney Creek Rd, Speewah, Queensland, Australia., Griffiths R; Island Conservation, Delaware Ave, Santa Cruz California, United States of America., Fisher RN; U.S. Geological Survey, Western Ecological Research Center, San Diego, California, United States of America., Wanless R; FitzPatrick Institute of African Ornithology, University of Cape Town, Rondebosch, South Africa.; BirdLife South Africa, Parklands, Johannesburg, South Africa., Pasachnik SA; Fort Worth Zoo, IUCN Iguana Specialist Group, Colonial Parkway, Fort Worth, Texas United States of America., Cranwell S; BirdLife Pacific, MacGregor Road, Suva, Fiji., Micol T; Ligue pour la Protection des Oiseaux, Fonderies Royales, 8 rue du Docteur Pujos, Rochefort, France.; Terres Australes et Antarctiques Françaises, rue Gabriel Dejean, Saint Pierre de la Réunion, France., Butchart SHM; BirdLife International, Cambridge, United Kigndom.; Department of Zoology, University of Cambridge, Cambridge, United Kigndom.

Publikováno v: PloS one [PLoS One] 2019 Mar 27; Vol. 14 (3), pp. e0212128. Date of Electronic Publication: 2019 Mar 27 (Print Publication: 2019).

Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan.

Autor: Borland, Gillian¹ (AUTHOR), Wilkie, Stephen E.¹ (AUTHOR), Thomson, Jackie¹ (AUTHOR), Wang, Zhe¹ (AUTHOR), Tullet, Jennifer M. A.² (AUTHOR), Alic, Nazif³ (AUTHOR), Selman, Colin¹ (AUTHOR) colin.selman@glasgow.ac.uk

Publikováno v: Aging Cell. May2024, Vol. 23 Issue 5, p1-5. 5p.

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