Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Cramer Christensen"'
Autor:
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosom
Externí odkaz:
https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e
Autor:
Jihua Sun, Christian Theil Have, Mette Hollensted, Niels Grarup, Allan Linneberg, Oluf Pedersen, Jens Steen Nielsen, Jørgen Rungby, Cramer Christensen, Ivan Brandslund, Karsten Kristiansen, Wang Jun, Torben Hansen, Anette P Gjesing
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220805 (2019)
BackgroundBased on the association of common GLIS3 variants with various forms of diabetes and the biological role of GLIS3 in beta-cells, we sequenced GLIS3 in non-diabetic and diabetic Danes to investigate the effect of rare missense variants on gl
Externí odkaz:
https://doaj.org/article/57a6bf9899b3414e87b059fe8ae3f9af
Autor:
Minako Imamura, Atsushi Takahashi, Toshimasa Yamauchi, Kazuo Hara, Kazuki Yasuda, Niels Grarup, Wei Zhao, Xu Wang, Alicia Huerta-Chagoya, Cheng Hu, Sanghoon Moon, Jirong Long, Soo Heon Kwak, Asif Rasheed, Richa Saxena, Ronald C. W. Ma, Yukinori Okada, Minoru Iwata, Jun Hosoe, Nobuhiro Shojima, Minaka Iwasaki, Hayato Fujita, Ken Suzuki, John Danesh, Torben Jørgensen, Marit E. Jørgensen, Daniel R. Witte, Ivan Brandslund, Cramer Christensen, Torben Hansen, Josep M. Mercader, Jason Flannick, Hortensia Moreno-Macías, Noël P. Burtt, Rong Zhang, Young Jin Kim, Wei Zheng, Jai Rup Singh, Claudia H. T. Tam, Hiroshi Hirose, Hiroshi Maegawa, Chikako Ito, Kohei Kaku, Hirotaka Watada, Yasushi Tanaka, Kazuyuki Tobe, Ryuzo Kawamori, Michiaki Kubo, Yoon Shin Cho, Juliana C. N. Chan, Dharambir Sanghera, Philippe Frossard, Kyong Soo Park, Xiao-Ou Shu, Bong-Jo Kim, Jose C. Florez, Teresa Tusié-Luna, Weiping Jia, E Shyong Tai, Oluf Pedersen, Danish Saleheen, Shiro Maeda, Takashi Kadowaki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared
Externí odkaz:
https://doaj.org/article/389e503091f247e28b5236cff3387f83
Autor:
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
In the originally published version of this Article, the affiliation details for Santi González, Jian’an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing Center (BSC
Externí odkaz:
https://doaj.org/article/202ddca41ed244ff9a8f095f544c3220
Autor:
Marie Neergaard Harder, Emil Vincent Rosenbaum Appel, Niels Grarup, Anette Prior Gjesing, Tarunveer S Ahluwalia, Torben Jørgensen, Cramer Christensen, Ivan Brandslund, Allan Linneberg, Thorkild I A Sørensen, Oluf Pedersen, Torben Hansen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120890 (2015)
ObjectivesA trans-ethnic meta-analysis of type 2 diabetes genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9. The aim of our study was t
Externí odkaz:
https://doaj.org/article/122555f7df954430833f5705e8eb5f1a
Autor:
Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004876 (2015)
Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contrib
Externí odkaz:
https://doaj.org/article/cec1ab88480748b08bff91f2f1d31386
Autor:
Kasper Meidahl Petersen, Torben Hansen, Trine Henriksen, Ivan Brandslund, Christian Torp-Pedersen, Thomas Mandrup-Poulsen, Vanja Cejvanovic, Laura Kofoed Kjær, Thomas A. Gerds, Cramer Christensen, Oluf Pedersen, Henrik E. Poulsen
Publikováno v:
Kjær, L K, Cejvanovic, V, Henriksen, T, Petersen, K M, Hansen, T, Pedersen, O, Christensen, C K, Torp-Pedersen, C, Gerds, T A, Brandslund, I, Mandrup-Poulsen, T & Poulsen, H E 2017, ' Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes : A Prospective Cohort Study ', Diabetes Care, vol. 40, no. 12, pp. 1771-1778 . https://doi.org/10.2337/dc17-1150
OBJECTIVE Cardiovascular mortality risk remains high among patients with type 2 diabetes. Oxidative stress indicated by high urinary excretion of the biomarker for RNA oxidation, 8-oxo-7,8-dihydroguanosine (8-oxoGuo), is associated with an increased
Autor:
Cramer Christensen, Henrik E. Poulsen, Allan Weimann, Emil List Larsen, Trine Henriksen, Elin Rebecka Carlsson, Ivan Brandslund, Mogens Fenger, Laura Kofoed Kjær
Publikováno v:
Poulsen, H E, Weimann, A, Henriksen, T, Kjær, L K, Larsen, E L, Carlsson, E R, Christensen, C K, Brandslund, I & Fenger, M 2019, ' Oxidatively generated modifications to nucleic acids in vivo : Measurement in urine and plasma ', Free Radical Biology and Medicine, vol. 145, pp. 336-341 . https://doi.org/10.1016/j.freeradbiomed.2019.10.001
Background: The oxidized guanine nucleosides, 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo), derived from DNA and RNA, respectively, were used to investigate the importance of oxidative stress to nucleic ac
Autor:
Christian Torp-Pedersen, Laura Kofoed Kjær, Trine Henriksen, Torben Hansen, Oluf Pedersen, Cramer Christensen, Ivan Brandslund, Thomas A. Gerds, Henrik E. Poulsen, Thomas Mandrup-Poulsen, Vanja Cejvanovic
Publikováno v:
Kofoed Kjær, L, Cejvanovic, V, Henriksen, T, Hansen, T, Pedersen, O, Kjeldahl Christensen, C, Torp-Pedersen, C, Alexander Gerds, T, Brandslund, I, Mandrup-Poulsen, T & Enghusen Poulsen, H 2019, ' Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes ', Free Radical Research, vol. 53, no. 6, pp. 694-703 . https://doi.org/10.1080/10715762.2019.1622011
Kofoed Kjær, L, Cejvanovic, V, Henriksen, T, Hansen, T, Pedersen, O, Kjeldahl Christensen, C, Torp-Pedersen, C, Alexander Gerds, T, Brandslund, I, Mandrup-Poulsen, T & Enghusen Poulsen, H 2019, ' Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes ', Free Radical Research, vol. 53, no. 6, pp. 694–703 . https://doi.org/10.1080/10715762.2019.1622011
Kofoed Kjær, L, Cejvanovic, V, Henriksen, T, Hansen, T, Pedersen, O, Kjeldahl Christensen, C, Torp-Pedersen, C, Alexander Gerds, T, Brandslund, I, Mandrup-Poulsen, T & Enghusen Poulsen, H 2019, ' Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes ', Free Radical Research, vol. 53, no. 6, pp. 694–703 . https://doi.org/10.1080/10715762.2019.1622011
The relationship between RNA and DNA oxidation and pharmacological treatment has not been systematically investigated in patients with type 2 diabetes (T2D). We aimed to investigate the association between pharmacological treatments and levels of uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5938947fb9343e25654805bb5bc2f9aa
https://portal.findresearcher.sdu.dk/da/publications/ef45d839-07fa-4c13-9615-1d83c591011c
https://portal.findresearcher.sdu.dk/da/publications/ef45d839-07fa-4c13-9615-1d83c591011c
Autor:
Ivan Brandslund, Torben Hansen, Jens Steen Nielsen, Cramer Christensen, Karsten Kristiansen, Niels Grarup, Oluf Pedersen, Anette P. Gjesing, Christian Theil Have, Jihua Sun, Jørgen Rungby, Mette Hollensted, Wang Jun, Allan Linneberg
Publikováno v:
PLoS ONE
Sun, J, Have, C T, Hollensted, M, Grarup, N, Linneberg, A, Pedersen, O, Nielsen, J S, Rungby, J, Christensen, C, Brandslund, I, Kristiansen, K, Jun, W, Hansen, T & Gjesing, A P 2019, ' Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants ', PLoS ONE, vol. 14, no. 8, e0220805 . https://doi.org/10.1371/journal.pone.0220805
Sun, J, Have, C T, Hollensted, M, Grarup, N, Linneberg, A, Pedersen, O, Nielsen, J S, Rungby, J, Christensen, C, Brandslund, I, Kristiansen, K, Jun, W, Hansen, T & Gjesing, A P 2019, ' Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants ', PLOS ONE, vol. 14, no. 8, e0220805 . https://doi.org/10.1371/journal.pone.0220805
PLOS ONE
PLoS ONE, Vol 14, Iss 8, p e0220805 (2019)
Sun, J, Have, C T, Hollensted, M, Grarup, N, Linneberg, A, Pedersen, O, Nielsen, J S, Rungby, J, Christensen, C, Brandslund, I, Kristiansen, K, Jun, W, Hansen, T & Gjesing, A P 2019, ' Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants ', PLoS ONE, vol. 14, no. 8, e0220805 . https://doi.org/10.1371/journal.pone.0220805
Sun, J, Have, C T, Hollensted, M, Grarup, N, Linneberg, A, Pedersen, O, Nielsen, J S, Rungby, J, Christensen, C, Brandslund, I, Kristiansen, K, Jun, W, Hansen, T & Gjesing, A P 2019, ' Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants ', PLOS ONE, vol. 14, no. 8, e0220805 . https://doi.org/10.1371/journal.pone.0220805
PLOS ONE
PLoS ONE, Vol 14, Iss 8, p e0220805 (2019)
BackgroundBased on the association of common GLIS3 variants with various forms of diabetes and the biological role of GLIS3 in beta-cells, we sequenced GLIS3 in non-diabetic and diabetic Danes to investigate the effect of rare missense variants on gl