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Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.

Autor: Amore BM; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA., Cramer CT; Nonclinical Pharma Solutions, LLC, Dexter, Michigan, USA., MacDougall DE; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA., Sasiela WJ; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA., Emery MG; Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2487-2496. Date of Electronic Publication: 2021 Aug 31.

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Measurement of bempedoic acid and its keto metabolite in human plasma and urine using solid phase extraction and electrospray LC-MS/MS.

Autor: Engel BJ; AIT Bioscience, LLC, 7840 Innovation Blvd, Indianapolis, IN 46278, USA., Preusch K; AIT Bioscience, LLC, 7840 Innovation Blvd, Indianapolis, IN 46278, USA., Brown C; AIT Bioscience, LLC, 7840 Innovation Blvd, Indianapolis, IN 46278, USA., Cramer CT; Esperion Therapeutics, 3891 Ranchero Drive, Suite 150, Ann Arbor, MI 48108, USA., Shoup R; AIT Bioscience, LLC, 7840 Innovation Blvd, Indianapolis, IN 46278, USA. Electronic address: rshoup@aitbioscience.com.

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Oct 01; Vol. 1154, pp. 122291. Date of Electronic Publication: 2020 Jul 30.

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Akademický článek

Complementary low-density lipoprotein-cholesterol lowering and pharmacokinetics of adding bempedoic acid (ETC-1002) to high-dose atorvastatin background therapy in hypercholesterolemic patients: A randomized placebo-controlled trial.

Autor: Lalwani ND; Esperion Therapeutics, Inc, Ann Arbor, MI, USA. Electronic address: nlalwani@esperion.com., Hanselman JC; Esperion Therapeutics, Inc, Ann Arbor, MI, USA., MacDougall DE; Esperion Therapeutics, Inc, Ann Arbor, MI, USA., Sterling LR; Esperion Therapeutics, Inc, Ann Arbor, MI, USA., Cramer CT; Esperion Therapeutics, Inc, Ann Arbor, MI, USA.

Publikováno v: Journal of clinical lipidology [J Clin Lipidol] 2019 Jul - Aug; Vol. 13 (4), pp. 568-579. Date of Electronic Publication: 2019 May 13.

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Akademický článek

Lemon basil seed-derived peptide: Hydrolysis, purification, and its role as a pancreatic lipase inhibitor that reduces adipogenesis by downregulating SREBP-1c and PPAR-γ in 3T3-L1 adipocytes.

Autor: Kuptawach, Kittisak¹ (AUTHOR), Noitung, Sajee² (AUTHOR), Buakeaw, Anumart² (AUTHOR), Puthong, Songchan² (AUTHOR), Sawangkeaw, Ruengwit² (AUTHOR), Sangtanoo, Papassara² (AUTHOR), Srimongkol, Piroonporn² (AUTHOR), Reamtong, Onrapak³ (AUTHOR), Choowongkomon, Kiattawee⁴ (AUTHOR), Karnchanatat, Aphichart² (AUTHOR) Aphichart.K@chula.ac.th

Publikováno v: PLoS ONE. 5/22/2024, Vol. 19 Issue 5, p1-32. 32p.

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Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling.

Autor: Pajic-Lijakovic, Ivana¹ (AUTHOR) iva@tmf.bg.ac.rs, Milivojevic, Milan¹ (AUTHOR), McClintock, Peter V. E.² (AUTHOR) p.v.e.mcclintock@lancaster.ac.uk

Publikováno v: Journal of Biological Engineering. 4/8/2024, Vol. 18 Issue 1, p1-19. 19p.

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A new workflow for the effective curation of membrane permeability data from open ADME information.

Autor: Esaki, Tsuyoshi^1,2 (AUTHOR) tsuyoshi-esaki@biwako.shiga-u.ac.jp, Yonezawa, Tomoki³ (AUTHOR), Ikeda, Kazuyoshi^3,4 (AUTHOR)

Publikováno v: Journal of Cheminformatics. 3/14/2024, Vol. 16 Issue 1, p1-11. 11p.

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Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator.

Autor: Se Hee Min¹, Do Kyeong Song², Chan Hee Lee³, Eun Roh⁴, Min-Seon Kim¹ mskim@amc.seoul.kr

Publikováno v: Endocrinology & Metabolism. Feb2024, Vol. 39 Issue 1, p1-11. 11p.

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Safety and efficacy of bempedoic acid among patients with statin intolerance and those without: A meta-analysis and a systematic randomized controlled trial review.

Autor: Li, Yi¹ (AUTHOR) liyi251668@163.com, Gao, Hongyu¹ (AUTHOR), Zhao, Jinghui¹ (AUTHOR), Ma, Liqing¹ (AUTHOR), Hu, Dan¹ (AUTHOR)

Publikováno v: PLoS ONE. 1/26/2024, Vol. 19 Issue 1, p1-13. 13p.

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Akademický článek

AMPK Signaling Pathway as a Potential Therapeutic Target for Parkinson's Disease.

Autor: Athari, Seyed Zanyar^1,2 (AUTHOR), Farajdokht, Fereshteh² (AUTHOR) farajdokhtf@tbzmed.ac.ir, Keyhanmanesh, Rana¹ (AUTHOR), Mohaddes, Gisou^2,3 (AUTHOR) farajdokhtf@tbzmed.ac.ir

Publikováno v: Advanced Pharmaceutical Bulletin. 2024, Vol. 14 Issue 1, p120-131. 12p.

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