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Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity

Autor: Craik, Charles, Skala, W, Utzschneider, DT, Magdolen, V, Debela, M, Guo, S, Craik, CS, Brandstetter, H, Goettig, P

Publikováno v: Craik, Charles; Skala, W; Utzschneider, DT; Magdolen, V; Debela, M; Guo, S; et al.(2014). Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/56j989h8

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.Human kallikrein-related peptidase 2 (KLK2) is a tryptic serine protease predominantly expressed in prostatic tissue and secreted into prostatic fluid, a major component of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e1002715f9bfbd6a1613b6a0247e8f7d
http://www.escholarship.org/uc/item/56j989h8

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Cullin E3 ligases and their rewiring by viral factors

Autor: Krogan, Nevan, Craik, Charles, Mahon, C, Krogan, NJ, Craik, CS, Pick, E

Publikováno v: Krogan, Nevan; Craik, Charles; Mahon, C; Krogan, NJ; Craik, CS; & Pick, E. (2014). Cullin E3 ligases and their rewiring by viral factors.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3xg8p11t

The ability of viruses to subvert host pathways is central in disease pathogenesis. Over the past decade, a critical role for the Ubiquitin Proteasome System (UPS) in counteracting host immune factors during viral infection has emerged. This countera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7aed05cd19d88ad05d575ffb65600838
http://www.escholarship.org/uc/item/3xg8p11t

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Broad-spectrum allosteric inhibition of herpesvirus proteases

Autor: Craik, Charles, Renslo, Adam, Gable, JE, Lee, GM, Jaishankar, P, Hearn, BR, Waddling, CA, Renslo, AR, Craik, CS

Publikováno v: Craik, Charles; Renslo, Adam; Gable, JE; Lee, GM; Jaishankar, P; Hearn, BR; et al.(2014). Broad-spectrum allosteric inhibition of herpesvirus proteases. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4s26r3mk

Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::33ccc1cda335b9083cf37b46fb39b7b5
http://www.escholarship.org/uc/item/4s26r3mk

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Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance

Autor: Craik, Charles, Vanbrocklin, Henry, LeBeau, AM, Sevillano, N, King, ML, Duriseti, S, Murphy, ST, Craik, CS, Murphy, LL, VanBrocklin, HF

Publikováno v: Craik, Charles; Vanbrocklin, Henry; LeBeau, AM; Sevillano, N; King, ML; Duriseti, S; et al.(2014). Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4q69m3nn

Subtype-targeted therapies can have a dramatic impact on improving the quality and quantity of life for women suffering from breast cancer. Despite an initial therapeutic response, cancer recurrence and acquired drug-resistance are commonplace. Non-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::1e7b1208ec4e2bcd97440a74578769eb
http://www.escholarship.org/uc/item/4q69m3nn

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