Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Craig. A. Townsend"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109572- (2024)
Externí odkaz:
https://doaj.org/article/638c1224672f4b26bbb96ed7bcc0f96e
Publikováno v:
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 4-10 (2021)
Externí odkaz:
https://doaj.org/article/a6f80892892a41a59bb5a335d44201cf
Autor:
Hunter R. Batchelder, Elizabeth Story-Roller, Evan P. Lloyd, Amit Kaushik, Kristina M. Bigelow, Emily C. Maggioncalda, Eric L. Nuermberger, Gyanu Lamichhane, Craig A. Townsend
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-5 (2020)
Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactama
Externí odkaz:
https://doaj.org/article/5e507dd0a49447c7b96b6dc7becd6906
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradig
Externí odkaz:
https://doaj.org/article/9c27a2affc1544e8b90f093016f2d727
Autor:
Ketan D. Patel, Felipe B. d’Andrea, Nicole M. Gaudelli, Andrew R. Buller, Craig A. Townsend, Andrew M. Gulick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
NocTE is a nonribosomal peptide synthetase thioesterase that completes the biosynthesis of pro-nocardicin G, the precursor for nocardicin β-lactam antibiotics. Here the authors provide mechanistic insights into NocTE by determining its crystal struc
Externí odkaz:
https://doaj.org/article/0edee8fbfb374cbf8bab9f96d03b7963
Publikováno v:
ACS Chemical Biology. 18:304-314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a1913e48ddb04d7f4f98eae2a149ca
https://doi.org/10.1021/acschembio.2c00709
https://doi.org/10.1021/acschembio.2c00709
Autor:
Michael S. Lichstrahl, Lukas Kahlert, Rongfeng Li, Trevor A. Zandi, Jerry Yang, Craig. A. Townsend
Publikováno v:
Chemical Science. 14:3923-3931
A small library of stereochemically-defined α,β-diamino acids has been prepared to generate non-native monobactams through fermentation, highlighting the potential of this platform for directed biosynthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201c50180aa9d77d0d750c43774015e1
https://doi.org/10.1039/d2sc06893a
https://doi.org/10.1039/d2sc06893a
Autor:
Michael J. Wheadon, Craig A. Townsend
Publikováno v:
ACS Chem Biol
Nonribosomal peptide synthetases (NRPSs) are a family of multidomain enzymes dedicated to the production of peptide natural products. Central to NRPS function are condensation (C) domains, which catalyze peptide bond formation and a number of special
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89864c5f8ecc3c66e9878ab60a0610b1
https://doi.org/10.1021/acschembio.2c00474
https://doi.org/10.1021/acschembio.2c00474
Publikováno v:
Nature. 602:343-348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373fe03a7c44089394481b1a7c12dbd9
https://doi.org/10.1038/s41586-021-04392-4
https://doi.org/10.1038/s41586-021-04392-4
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
Complex carbapenems are important clinical antibiotics used to treat recalcitrant infections. Their biosynthetic gene clusters contain three essential B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc316f8d64969d53ddd12d7c3b7a475f
https://pubmed.ncbi.nlm.nih.gov/35969793
https://pubmed.ncbi.nlm.nih.gov/35969793