Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Craig Zupke"'
1
Real-time product attribute control to manufacture antibodies with defined N-linked glycan levels
Autor: Brittney Livingston, Arvia E. Morris, Peter G. Slade, Lowell J. Brady, Robert Bailey, Craig Zupke, Lisa Taylor, Kyle Bigham, Philip Clark, R. Guy Caspary
Publikováno v: Biotechnology Progress. 31:1433-1441
Pressures for cost-effective new therapies and an increased emphasis on emerging markets require technological advancements and a flexible future manufacturing network for the production of biologic medicines. The safety and efficacy of a product is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3cb3292918319646e789c2251510b5
https://doi.org/10.1002/btpr.2136
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2
Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures
Autor: David Treiber, Brian D. Follstad, Zhimei Du, Yuling Zhang, Pranhitha Reddy, Brad Dell, Carole Heath, Dina Fomina-Yadlin, Ramsey A. Saleem, Arvia E. Morris, Craig Zupke, Matthew Leith, Brent Grisim, John D. McCarter, Rebecca E. Mccoy, Tharmala Tharmalingam
Publikováno v: Biotechnology and Bioengineering
The continued need to improve therapeutic recombinant protein productivity has led to ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish robust processes with optimized critical variables, that is, viable cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782a5dfaef3b9c854fc644324cd3702b
https://pubmed.ncbi.nlm.nih.gov/25042542
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3
Metabolic effects of stress mediators on cultured hepatocytes
Autor: Martin L. Yarmush, Craig Zupke, Francois Berthiaume, P. Stefanovich
Publikováno v: Biotechnology and Bioengineering. 58:222-230
Stress mediators play a major role in inducing the hypermetabolic stress state in the liver after major injuries. The majority of studies on the effect of mediators on hepatocytes have focused on single factor effects or on the effect of very complex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e2833b887d8d86e0ab8732ea8992402
https://doi.org/10.1002/(sici)1097-0290(19980420)58:2/3<222::aid-bit15>3.0.co
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4
TCA cycle flux estimates from NMR- and GC-MS-determined [13C]glutamate isotopomers in liver
Autor: Ronald G. Tompkins, Yong Ming Yu, J. F. Burke, Craig Zupke, J. A. Vogt, A. J. Fischman, D. M. Yarmush
Publikováno v: American Journal of Physiology-Cell Physiology. 272:C2049-C2062
Infusion of 13C-labeled lactate into rabbits and the subsequent measurement of glutamate isotopomers by 13C nuclear magnetic resonance (NMR) spectroscopy enables one to calculate relative flow rates associated with the tricarboxylic acid (TCA) cycle,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a6c4f6b59ab68ed548378357754195
https://doi.org/10.1152/ajpcell.1997.272.6.c2049
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5
Effect of burn injury on glucose and nitrogen metabolism in the liver: Preliminary studies in a perfused liver system
Autor: Yoshihiro Yamaguchi, Ronald G. Tompkins, Francois Berthiaume, Yong-Ming Yu, Craig Zupke, David M. Yarmush, Martin L. Yarmush
Publikováno v: Surgery. 121:295-303
Background. The direct impact of burn injury on liver metabolism was studied in a rat liver perfusion system to remove the influence of systemic factors that modulate liver metabolism. Methods. Seven animals received a burn injury covering 20% of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f35702a8ccfafdcf361fe690e5c5589
https://doi.org/10.1016/s0039-6060(97)90358-5
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6
Intracellular flux analysis in hybridomas using mass balances and in vitro13C nmr
Autor: Craig Zupke, Gregory Stephanopoulos
Publikováno v: Biotechnology and Bioengineering. 45:292-303
Intracellular fluxes are important in defining cellular physiology and its changes in response to environmental variations. Stoichiometric balances combined with extra cellular metabolite measurements were applied to the estimation of intracellular f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf09e822cb725edffb2aa887473c277
https://doi.org/10.1002/bit.260450403
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7
Nuclear magnetic resonance analysis of cell metabolism
Autor: Brent D. Foy, Craig Zupke
Publikováno v: Current Opinion in Biotechnology. 6:192-197
Nuclear magnetic resonance (NMR) continues to be a useful tool for the study of cellular metabolism. A variety of NMR techniques have been developed or newly applied to the analysis of cell systems. Many of these techniques are particularly useful fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2795ce4db4e0414eedd04c42c2dda5fe
https://doi.org/10.1016/0958-1669(95)80031-x
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8
Modeling of Isotope Distributions and Intracellular Fluxes in Metabolic Networks Using Atom Mapping Matrixes
Autor: Gregory Stephanopoulos, Craig Zupke
Publikováno v: Biotechnology Progress. 10:489-498
The modeling of isotope distributions can be used to evaluate intracellular fluxes and to investigate cellular metabolism. A method of modeling isotope distributions in biochemical networks that addresses some of the shortcomings of conventional meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::546ec20814257669bb2de358fb6af88a
https://doi.org/10.1021/bp00029a006
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