Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Craig T. Werner"'
Autor:
Bo Liang, Lifeng Zhang, Yan Zhang, Craig T. Werner, Nicholas J. Beacher, Alex J. Denman, Yun Li, Rong Chen, Charles R. Gerfen, Giovanni Barbera, Da-Ting Lin
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104245- (2022)
Summary: Dorsal striatum is important for movement control and motor skill learning. However, it remains unclear how the spatially and temporally distributed striatal medium spiny neuron (MSN) activity in the direct and indirect pathways (D1 and D2 M
Externí odkaz:
https://doaj.org/article/a5219218ce5d492ab5e20e9c9468c7ed
Autor:
Nicholas J. Beacher, Kayden A. Washington, Craig T. Werner, Yan Zhang, Giovanni Barbera, Yun Li, Da-Ting Lin
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Substance use disorder (SUD) is comorbid with devastating health issues, social withdrawal, and isolation. Successful clinical treatments for SUD have used social interventions. Neurons can encode drug cues, and drug cues can trigger relapse. It is i
Externí odkaz:
https://doaj.org/article/df196171822a43c9a034412441d15cd8
Autor:
Jennifer A. Martin, Craig T. Werner, Swarup Mitra, Ping Zhong, Zi-Jun Wang, Pedro H. Gobira, Andrew. F. Stewart, Jay Zhang, Kyra Erias, Justin N. Siemian, Devin Hagarty, Lauren E. Mueller, Rachael L. Neve, Jun-Xu Li, Ramesh Chandra, Karen C. Dietz, Mary Kay Lobo, Amy M. Gancarz, Zhen Yan, David M. Dietz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the
Externí odkaz:
https://doaj.org/article/fd3986183cd145e696e221b400cee251
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), are devastating age-associated brain disorders. Si
Externí odkaz:
https://doaj.org/article/7d555cca3bc845109396be15f31df745
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Autor:
Jacob D. Layne, Mason J. Hochstetler, Brandon M. Curry, Benjamin M. Williams, Christina A. Small, Scott C. Steffensen, Hugo R. Arias, Craig T. Werner
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Autor:
Swarup Mitra, Amy M. Gancarz, David M. Dietz, Benjamin D. Auerbach, Jennifer A. Martin, Zi-Jun Wang, Richard Salvi, Madoka Iida, Pedro H. Gobira, Aaron Caccamise, Chunna An, Moriah M. Cobb, Andrew F. Stewart, Rachael L. Neve, Craig T. Werner
Publikováno v:
Proceedings of the National Academy of Sciences. 117:26460-26469
Relapse vulnerability in substance use disorder is attributed to persistent cue-induced drug seeking that intensifies (or "incubates") during drug abstinence. Incubated cocaine seeking has been observed in both humans with cocaine use disorder and in
Autor:
Zi-Jun Wang, Erin S. Calipari, Henrik Molina, Swarup Mitra, Ryan M. Bastle, Ian Maze, Yang Lyu, Paul J. Kenny, Li Shen, David M. Dietz, Richard M. O'Connor, Lorna A. Farrelly, Jennifer A. Martin, Gustavo Turecki, Aarthi Ramakrishnan, Sasha L. Fulton, Alexander C.W. Smith, Ashley E. Lepack, Craig T. Werner, Ping Zhong, Zhen Yan, Andrew F. Stewart
Publikováno v:
Science
More than a normal neurotransmitter The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack et al. found that, with cocaine exposure, there is an intracellular accumulation of dopamine in neurons of a brain reg
Autor:
Craig T. Werner, Yan Zhang, Da-Ting Lin, Nicholas J. Beacher, Yun Li, Kayden A. Washington, Giovanni Barbera
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Frontiers in Neural Circuits
Frontiers in Neural Circuits
Substance use disorder (SUD) is comorbid with devastating health issues, social withdrawal, and isolation. Successful clinical treatments for SUD have used social interventions. Neurons can encode drug cues, and drug cues can trigger relapse. It is i
Autor:
Zi-Jun Wang, Amy M. Gancarz, Pedro H. Gobira, Ping Zhong, Kyra Erias, Zhen Yan, Swarup Mitra, Jennifer A. Martin, Craig T. Werner, Justin N. Siemian, Lauren E. Mueller, Andrew F. Stewart, Rachael L. Neve, Jay Zhang, Ramesh Chandra, David M. Dietz, Mary Kay Lobo, Devin Hagarty, Jun-Xu Li, Karen C. Dietz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Persistent transcriptional and morphological events in the nucleus accumbens (NAc) and other brain reward regions contribute to the long-lasting behavioral adaptations that characterize drug addiction. Opiate exposure reduces the density of dendritic