Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Craig T. Morita"'
Autor:
Inthuon Kulma, Kesara Na-Bangchang, Andrea Carvallo Herrera, Ifeanyi Theodora Ndubuisi, Masashi Iwasaki, Hiromi Tomono, Craig T. Morita, Haruki Okamura, Hiroshi Mukae, Yoshimasa Tanaka
Publikováno v:
Cells, Vol 13, Iss 16, p 1322 (2024)
Cholangiocarcinoma (CCA) is a rare disease characterized by malignant cells derived from the epithelial cells of the biliary duct system. Despite extensive treatments, the prognosis for CCA remains poor, emphasizing the critical need for the developm
Externí odkaz:
https://doaj.org/article/0779c4f3e4f64c1eacccc86ee1f64085
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Human Vγ2Vδ2 (also termed Vγ9Vδ2) T cells play important roles in microbial and tumor immunity by monitoring foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis. Accumulation of isoprenoid metabolites after bisphosphonat
Externí odkaz:
https://doaj.org/article/44888b298b5348eaa2d0982d33df0a10
Autor:
Daisuke Okuno, Yuki Sugiura, Noriho Sakamoto, Mohammed S. O. Tagod, Masashi Iwasaki, Shuto Noda, Akihiro Tamura, Hiroaki Senju, Yasuhiro Umeyama, Hiroyuki Yamaguchi, Makoto Suematsu, Craig T. Morita, Yoshimasa Tanaka, Hiroshi Mukae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl
Externí odkaz:
https://doaj.org/article/02142f0fc54e475fb2d9290f2b7ef0f4
Autor:
Yoshimasa Tanaka, Masashi Iwasaki, Kaoru Murata-Hirai, Kenji Matsumoto, Kosuke Hayashi, Haruki Okamura, Tomoharu Sugie, Nagahiro Minato, Craig T. Morita, Masakazu Toi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited effic
Externí odkaz:
https://doaj.org/article/9f0bf342bae840ad95d227a5c3a671ad
Publikováno v:
J Immunol
Vγ2Vδ2 T cells play important roles in human immunity to pathogens and tumors. Their TCRs respond to the sensing of isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and isopentenyl pyrophosphate, by butyrophilin (BTN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b3effae7ee3774769a7a816151a0a
https://doi.org/10.4049/jimmunol.1801252
https://doi.org/10.4049/jimmunol.1801252
Autor:
Yoshimasa Tanaka, Masashi Iwasaki, Hiroshi Mukae, Yuki Sakai, Hiroaki Senju, Mohammed S. O. Tagod, Craig T. Morita, Kengo Shiraishi, Satoshi Mizuta
Publikováno v:
Journal of Immunological Methods. 466:32-40
The adoptive transfer of immune effector cells, such as CD8(+) killer αβ T cells, γδ T cells, NK (natural killer) cells, and genetically–modified T cells, has been receiving increasing attention. It is essential to determine cellular cytotoxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043d23045542ab9d0a42e701b5e0c701
https://doi.org/10.1016/j.jim.2019.01.003
https://doi.org/10.1016/j.jim.2019.01.003
Autor:
Hiroshi Mukae, Masashi Iwasaki, Hiroaki Senju, Mohammed S. O. Tagod, Yoichi Nakamura, Craig T. Morita, Yoshimasa Tanaka, Satoshi Mizuta
Publikováno v:
ChemMedChem. 14:462-468
Immune checkpoint blockade using anti-PD-1/PD-L1 or anti-CTLA-4 monoclonal antibodies (mAbs) has revolutionized cancer treatment. However, many types of cancer do not respond and for those that do, only a minority of patients achieve durable remissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae7572463e3b6ff4083f884b8dd7d72
https://doi.org/10.1002/cmdc.201800764
https://doi.org/10.1002/cmdc.201800764
Autor:
Yasuhiro Umeyama, Makoto Suematsu, Akihiro Tamura, Yoshimasa Tanaka, Shuto Noda, Mohammed S. O. Tagod, Masashi Iwasaki, Hiroyuki Yamaguchi, Hiroaki Senju, Daisuke Okuno, Yuki Sugiura, Hiroshi Mukae, Noriho Sakamoto, Craig T. Morita
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a novel bisphosphonate prodrug, tetrakis-pivaloyloxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160acaf0b5dd0dacd75f5e6a0044ea4e
http://europepmc.org/articles/PMC7385076
http://europepmc.org/articles/PMC7385076
Autor:
Mohanad H. Nada, Asuka Kumagai, Craig T. Morita, Haruki Okamura, Yoshimasa Tanaka, Masashi Iwasaki, Kosuke Hayashi, Tomoharu Sugie, Nagahiro Minato, Masakazu Toi, Hirohito Kobayashi, Hong Wang, Hiroshi Kamitakahara, Kenji Matsumoto, Kaoru Murata-Hirai
Publikováno v:
Cancer Science
Cancer immunotherapy with human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) has shown promise because of their ability to recognize and kill most types of tumors in a major histocombatibility complex (MHC) -unrestricted fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164b5de10cd57400f22732b5706222fb
http://europepmc.org/articles/PMC5834800
http://europepmc.org/articles/PMC5834800
Autor:
Yoshimasa Tanaka, Satoshi Mizuta, Craig T. Morita, Yuki Sakai, Asuka Kumagai, Hiroaki Senju, Tatsufumi Nakamura, Mohammed S. O. Tagod
Publikováno v:
ChemMedChem. 12(23):2006-2013
Immunotherapy using immune checkpoint inhibitors and CAR-T cells has revolutionized treatment for patients with malignant tumors. However, measuring tumor cell cytotoxicity mediated by immune effector cells in clinical laboratories has been difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9320afc57300ae2f48125090071d4fd2
http://hdl.handle.net/10069/38318
http://hdl.handle.net/10069/38318