Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy

Autor: Cassandra E. Callmann, Dehong Hu, John Cliff, Stephen B. Howell, Maria T. Proetto, Nathan C. Gianneschi, Craig Szymanski, James E. Evans, Galya Orr

Publikováno v: ACS central science, vol 4, iss 11
ACS Central Science
Proetto, Maria T; Callmann, Cassandra E; Cliff, John; Szymanski, Craig J; Hu, Dehong; Howell, Stephen B; et al.(2018). Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy. ACS CENTRAL SCIENCE, 4(11), 1477-1484. doi: 10.1021/acscentsci.8b00444. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0n37z584
ACS Central Science, Vol 4, Iss 11, Pp 1477-1484 (2018)

In nanomedicine, determining the spatial distribution of particles and drugs, together and apart, at high resolution within tissues, remains a major challenge because each must have a different label or detectable feature that can be observed with hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75767cecdb084b8120a109bda9efd128
https://doi.org/10.1021/acscentsci.8b00444

Shifts in oxidation states of cerium oxide nanoparticles detected inside intact hydrated cells and organelles

Autor: Craig Szymanski, Dehong Hu, Galya Orr, Suntharampillai Thevuthasan, Mary K. Gilles, Yumei Xie, Cosmin Mihai, Prabhakaran Munusamy, Tolek Tyliszczak, Donald R. Baer

Publikováno v: Biomaterials. 62:147-154

Cerium oxide nanoparticles (CNPs) have been shown to induce diverse biological effects, ranging from toxic to beneficial. The beneficial effects have been attributed to the potential antioxidant activity of CNPs via certain redox reactions, depending

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583cde42ac7e9bef31dda8e0c75d4d57
https://doi.org/10.1016/j.biomaterials.2015.05.042

In Situ Molecular Imaging of the Biofilm and Its Matrix

Autor: Xiao-Ying Yu, James K. Fredrickson, Yuanzhao Ding, Liang Shi, Yufan Zhou, Zihua Zhu, Bin Cao, Craig Szymanski, Juan Yao

Publikováno v: Analytical chemistry. 88(22)

Molecular mapping of live biofilms at submicrometer resolution presents a grand challenge. Here, we present the first chemical mapping results of biofilm extracellular polymeric substance (EPS) in biofilms using correlative imaging between super reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab163f4a4eda535e12dd362f98654934
https://pubmed.ncbi.nlm.nih.gov/27709903

Nanoscale 3D Tracking with Conjugated Polymer Nanoparticles

Autor: Lawrence P. Fernando, Sushant Sahu, Craig Szymanski, Jason McNeill, Changfeng Wu, Jiangbo Yu

Publikováno v: Journal of the American Chemical Society. 131:18410-18414

Small ( approximately 15 nm diameter), highly fluorescent conjugated polymer nanoparticles were evaluated for nanoscale 2D and 3D tracking applications. Nanoparticles composed of conjugated polymers possess high absorption cross sections, high radiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc095ae95aa83f7e9ead275c122d591
https://doi.org/10.1021/ja907228q

Energy Transfer in a Nanoscale Multichromophoric System: Fluorescent Dye-Doped Conjugated Polymer Nanoparticles

Autor: Craig Szymanski, Jason McNeill, Yueli Zheng, Changfeng Wu

Publikováno v: The Journal of Physical Chemistry C. 112:1772-1781

We report on the fluorescence properties and the combined effects of energy diffusion and energy transfer in polyfluorene nanoparticles doped with a variety of fluorescent dyes. As the doping host, polyfluorene possesses extraordinary "light harvesti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8236b0f53cebc5278b341cd3f0452af
https://doi.org/10.1021/jp074149+